Juvenile hormone production by wild type and apterous 4 mutant Drosophila melanogaster corpora allata in vitro

Altaratz, Michal; Segal, Daniel; Richard, David; Gilbert, Lawrence I.; Applebaum, Shalom W.

doi:10.1007/978-1-4612-4512-4_37

Cited by 3 publications

(6 citation statements)

References 7 publications

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“…The ap 56f mutant of D. melanogaster has dramatically decreased JH synthesis (12% of the wild‐type rate) (Altaratz et al ., 1990, 1991) and a reduced JH titre (M. Bownes & H. Rembold, unpublished data). Therefore, JH degradation could be lowered in ap 56f if it is regulated by the hormone titre, as is the case during metamorphosis (see review by Hammock, 1985).…”

Section: Discussionmentioning

confidence: 99%

“…The Drosophila ap gene encodes the LIM‐homeodomain transcription factor (Bourgouin et al ., 1992; Cohen et al ., 1992). ap has pleiotrophic effects: its function is essential for viability, normal development of the wings and of a subset of embryonic muscles (Wilson, 1981a,b; Bourgouin et al ., 1992), for normal male and female sexual behaviour and female fertility (Gavin & Williamson, 1976; Ringo et al ., 1991, 1992) and for JH production (Altaratz et al ., 1990, 1991). We used the ap 56f allele because it does not cause the sterility and precocious adult death which is observed with some ap alleles (Wilson, 1981a,b).…”

Section: Introductionmentioning

confidence: 99%

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Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f

Грунтенко

Chentsova

Andreenkova

et al. 2003

Insect Molecular Biology

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The apterous56f (ap56f) mutation leads to increases in juvenile hormone (JH) degradation levels and JH-esterase makes a greater contribution to the increase than JH-epoxide hydrolase. Dopamine levels in ap56f females, but not males, are higher than in wild-type. JH treatment of ap56f and wild-type females decreases their dopamine levels. ap56f females, but not males, produce less progeny. Survival under heat stress is dramatically decreased in ap56f females, but not males. ap56f flies show a stress reaction, as judged by changes in tyrosine decarboxylase and JH-hydrolysing activities, dopamine levels and fertility, but its intensity in the mutant females, but not males, differs significantly from wild-type. Thus, the ap56f mutation causes dramatic changes in female, but not male, metabolism and fitness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f

Грунтенко

Chentsova

Andreenkova

et al. 2003

Insect Molecular Biology

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“…Corpus allatum of young, reproductively immature wild-type D. melunoguster produce significantly more JHIII and MF on the first day after adult eclosion (Altaratz et al, 1990(Altaratz et al, , 1991 and we have found increased production of JHIII and MF to be invariably linked to stress or reduced levels of total JHB3 biosynthesis in vitro. In adult Culliphoru vomitoriu CA, an excess of exogenous FA leads to accumulation of JHIII (7-fold above control levels) but no additional JHB, is produced (Duve et al, 1992).…”

Section: Allatal Response To Attached Brain and To Brain Extractmentioning

confidence: 89%

“…6) ( P < 0.01). The small amounts of MF and JHIII observed are commonly produced by CA complexes in control incubations (Altaratz et al, 1990(Altaratz et al, ,1991.…”

Section: Allatal Response To Attached Brain and To Brain Extractmentioning

confidence: 98%

“…Methyl 6,7;10,11-bisepoxyfarnesoate (JHB,) have been identified in the cyclorrhaphous Diptera as the major in vitro JH product of larval ring gland (Richard et al, 1989a(Richard et al, ,b, 1990 and of adult corpus allatum-corpus cardiacum complexes (CAI (Altaratz et al, 1990(Altaratz et al, , 1991Cusson et al, 1991;Duve et al, 1992;Lefevere et al, 1993). Minute amounts of JHIII has been identified in whole body extracts of wild-type Drosopkila melanogaster larvae and adults (Sliter et al, 1987;Bownes and Rembold, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Pathway and regulation of JHIII‐bisepoxide biosynthesis in adult Drosophila melanogaster corpus allatum

Moshitzky

Applebaum

1995

Arch Insect Biochem Physiol

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Adult female Drosophila melanogaster corpus allatum (CA) synthesize JHB3 from endogenous and exogenous precursors in vitro. We present evidence supporting the thesis that biosynthesis proceeds from precursor FA via initial epoxidation and terminal methylation on the basis of the following: (1) Methyl farnesoate is not epoxidized to JHIII or JHB3; (2) Authentic JHIII is not epoxidized to JHB3; and (3) FABE is markedly metabolized to JHB3. Cerebral allatostatic factors act at some stage subsequent to FA and this precursor is not normally rate-limiting. Additionally, neural inhibition from the brain acts at some biosynthetic step prior to FA.

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A reappraisal of the hormonal regulation of larval fat body histolysis in femaleDrosophila melanogaster

1993

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The histolysis of larval fat body cells in adult female Drosophila melanogaster was examined in wild type and mutant animals. The fat body cells of wild type (Canton-S), apterous56f homozygotes, apterous78jts homozygotes and heterozygotes, apterous4/+, ecdysoneless1 homozygotes and heterozygotes all underwent histolysis normally during the 72 h following adult eclosion. Only in the case of ap4/ap4 adults did the cells fail to histolyze normally. The fat body cells of both diapausing and non-diapausing wild type females underwent histolysis at the same rate. Attempts to demonstrate histolysis in vitro were unsuccessful, even in the presence of juvenile hormones (JHs), larval ring glands, or adult ovaries. In all strains other than the ap4 homozygotes, a significant proportion of larval fat body cells were dead at any time while the ap4/ap4 animals, almost all cells remained viable. It is postulated that fat body cell lysis following eclosion is not a JH-mediated event, but is elicited by an as yet unidentified factor(s), possibly originating in the ovary.

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Juvenile hormone production by wild type and apterous 4 mutant Drosophila melanogaster corpora allata in vitro

Cited by 3 publications

References 7 publications

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f

Pathway and regulation of JHIII‐bisepoxide biosynthesis in adult Drosophila melanogaster corpus allatum

A reappraisal of the hormonal regulation of larval fat body histolysis in femaleDrosophila melanogaster

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Juvenile hormone production by wild type and apterous 4 mutant Drosophila melanogaster corpora allata in vitro

Cited by 3 publications

References 7 publications

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous56f

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous56f

Pathway and regulation of JHIII‐bisepoxide biosynthesis in adult Drosophila melanogaster corpus allatum

A reappraisal of the hormonal regulation of larval fat body histolysis in femaleDrosophila melanogaster

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Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f

Stress response in a juvenile hormone‐deficient Drosophila melanogaster mutant apterous^56f