Juvenile hormone diol kinase, a calcium-binding protein with kinase activity, from the silkworm, Bombyx mori

Li, Sheng; Xu, Wei‐Hua; Schooley, David A.

doi:10.1016/j.ibmb.2005.06.005

Cited by 36 publications

(42 citation statements)

References 34 publications

(71 reference statements)

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“…Our microarray data and quantitative RT-PCR experiments in B. mori showed that some copies of the JH-related genes exhibited moderate expression in the head (mainly containing CA, CC, and brain) or in a dynamic manner that correlated with the temporal changes in JH titer, such as FPPS1 , FPPS2 , JHAMT-l3 , JHAMT-l4, JHE-l1 , JHEH-l5 , JHDK , and JHDK-l2 . Previous studies have confirmed the enzymatic activities or physiological functions of several JH-related genes in B. mori , such as JHAMT (Shinoda and Itoyama, 2003), JHE (Tan et al , 2005), JHEH (Seino et al , 2010), and JHDK (Li et al , 2005). One copy of the JHAMT gene has also been verified to be activated functionally in JH biosynthesis in T. castaneum (Minakuchi and Riddiford, 2008).…”

Section: Discussionmentioning

confidence: 81%

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Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

et al. 2014

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Juvenile hormone (JH) contributes to the regulation of larval molting and metamorphosis in insects. Herein, we comprehensively identified 55 genes involved in JH biosynthesis, metabolism and signaling in the silkworm (Bombyx mori) as well as 35 in Drosophila melanogaster, 35 in Anopheles gambiae, 36 in Apis mellifera, 47 in Tribolium castaneum, and 44 in Danaus plexippus. Comparative analysis showed that each gene involved in the early steps of the mevalonate (MVA) pathway, in the neuropeptide regulation of JH biosynthesis, or in JH signaling is a single copy in B. mori and other surveyed insects, indicating that these JH-related pathways or steps are likely conserved in all surveyed insects. However, each gene participating in the isoprenoid branch of JH biosynthesis and JH metabolism, together with the FPPS genes for catalyzing the final step of the MVA pathway of JH biosynthesis, exhibited an obvious duplication in Lepidoptera, including B. mori and D. plexippus. Microarray and real-time RT-PCR analysis revealed that different copies of several JH-related genes presented expression changes that correlated with the dynamics of JH titer during larval growth and metamorphosis. Taken together, the findings suggest that duplication-derived copy variation of JH-related genes might be evolutionarily associated with the variation of JH types between Lepidoptera and other insect orders. In conclusion, our results provide useful clues for further functional analysis of JH-related genes in B. mori and other insects.

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Section: Discussionmentioning

confidence: 81%

“…To date, JHDK has been functionally characterized in two Lepidoptera insects, namely, B. mori and Manduca sexta (Maxwell et al , 2002; Li et al , 2005). Here, three copies of the JHDK gene were identified in the B. mori genome (Table 1), including one authentic JHDK and two JHDK- like genes, each of which contains an EF-hand domain.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

et al. 2014

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“…The silkworm JH biosynthetic pathway can be divided into two main stages: the early steps, up to farnesyl diphosphate (FPP) formation, belong to the mevalonate pathway, and the late steps control the conversion of FPP into JH [68]. JH is then metabolized to JH acid diol and JH diol phosphate [69]. On the other hand, JH can bind to JH-binding proteins and regulate target gene expression.…”

Section: Resultsmentioning

confidence: 99%

A Genome-Wide Survey for Host Response of Silkworm, Bombyx mori during Pathogen Bacillus bombyseptieus Infection

et al. 2009

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Host-pathogen interactions are complex relationships, and a central challenge is to reveal the interactions between pathogens and their hosts. Bacillus bombysepticus (Bb) which can produces spores and parasporal crystals was firstly separated from the corpses of the infected silkworms (Bombyx mori). Bb naturally infects the silkworm can cause an acute fuliginosa septicaemia and kill the silkworm larvae generally within one day in the hot and humid season. Bb pathogen of the silkworm can be used for investigating the host responses after the infection. Gene expression profiling during four time-points of silkworm whole larvae after Bb infection was performed to gain insight into the mechanism of Bb-associated host whole body effect. Genome-wide survey of the host genes demonstrated many genes and pathways modulated after the infection. GO analysis of the induced genes indicated that their functions could be divided into 14 categories. KEGG pathway analysis identified that six types of basal metabolic pathway were regulated, including genetic information processing and transcription, carbohydrate metabolism, amino acid and nitrogen metabolism, nucleotide metabolism, metabolism of cofactors and vitamins, and xenobiotic biodegradation and metabolism. Similar to Bacillus thuringiensis (Bt), Bb can also induce a silkworm poisoning-related response. In this process, genes encoding midgut peritrophic membrane proteins, aminopeptidase N receptors and sodium/calcium exchange protein showed modulation. For the first time, we found that Bb induced a lot of genes involved in juvenile hormone synthesis and metabolism pathway upregulated. Bb also triggered the host immune responses, including cellular immune response and serine protease cascade melanization response. Real time PCR analysis showed that Bb can induce the silkworm systemic immune response, mainly by the Toll pathway. Anti-microorganism peptides (AMPs), including of Attacin, Lebocin, Enbocin, Gloverin and Moricin families, were upregulated at 24 hours post the infection.

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“…In insect, JH is principally degraded by two hydrolases, JH epoxide hydrolase (JHEH, EC 3.3.2.3) and JH esterase (JHE, EC 3.1.1.1) (Share and Roe, 1988;Debernard et al, 1998;Hirai et al, 2002;Maxwell et al, 2002a,b;Li et al, 2005;Zhang et al, 2005). JHEH belongs to the microsomal epoxide hydrolase family, and transforms epoxides to compounds with decreased chemical reactivity, increased water solubility, and altered biological activity (Arand et al, 2005;Morisseau and Hammock, 2005).…”

Section: Introductionmentioning

confidence: 99%

Characterization of two juvenile hormone epoxide hydrolases by RNA interference in the Colorado potato beetle

Lü

Guo

et al. 2015

Gene

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Juvenile hormone diol kinase, a calcium-binding protein with kinase activity, from the silkworm, Bombyx mori

Cited by 36 publications

References 34 publications

Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects

A Genome-Wide Survey for Host Response of Silkworm, Bombyx mori during Pathogen Bacillus bombyseptieus Infection

Characterization of two juvenile hormone epoxide hydrolases by RNA interference in the Colorado potato beetle

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