Juvenile Granulosa and Theca Cell Tumor of the Ovary as a Rare Cause of Precocious Puberty: Case Report and Review of Literature

Fleming, Nathalie; Nanassy, Joseph de; Lawrence, Sarah

doi:10.1016/j.jpag.2010.01.003

Cited by 22 publications

(9 citation statements)

References 16 publications

(28 reference statements)

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“…46 In general, granulosa cell tumors are divided into juvenile and adult types. 47 Survival rate for stage 1 is 78% to 92% and for stage 1A is 83% to 98%. 47 This often leads to diagnosis at an earlier stage.…”

Section: Sex-cord Stromal Malignanciesmentioning

confidence: 98%

Diagnosis and Management of Pelvic Masses in Children and Adolescents

Damle¹

2011

Postgraduate Obstetrics & Gynecology

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Section: Sex-cord Stromal Malignanciesmentioning

confidence: 98%

Diagnosis and Management of Pelvic Masses in Children and Adolescents

Damle¹

2011

Postgraduate Obstetrics & Gynecology

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“…Juvenile Granulosa and Theca Cell Tumor are stromal ovarian carcinomas very rare in children. Surgery is necessary for histological diagnosis, staging, and debulking, but an excellent prognosis is related to early stage disease (42). Chemotherapy is indicated for stage IC or higher by FIGO (International Federation of Gynecology and Obstetrics) and it is based on cisplatin associated to ifosfamide and etoposide (PEI) or to etoposide and bleomycin (PEB) (43,44).…”

Section: Ovarian Tumorsmentioning

confidence: 99%

Gynecological cancer among adolescents and young adults (AYA)

et al. 2020

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Adolescents and young adults (AYA) patients with cancer show specific biological, sociodemographic and behavioral features, with lower survival rates than younger group. Gynecologic malignancies that occur among AYA requires a multidisciplinary management and a tailored model of care, in order to enhance the early diagnosis, the adherence to the treatment, the enrollment in clinical trials, the rate of survival and the quality of life (QoL). In this article, we review the main gynecological tumors that may occur in AYA, with a focus on the clinical signs at the diagnosis and the modality of treatment. In addition, we proposed a model of multidisciplinary and personalized care for AYA with gynecological tumors, which can help the clinicians to manage the specific gynecologic concerns, such as ovarian failure, contraception, fertility, late psychosocial effects.

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“…These neoplasm are mostly hormone active and usually produce estrogen. The commonest presentation related to the hormone effects is precocious pseudopuberty [7]. Other presentation is acute abdomen due to tumor rupture and abdominal distention [3].…”

Section: Uterusmentioning

confidence: 99%

Ascites as a Sole Presentation of Juvenile Granulosa Cell Tumor

Dhaiban¹

2015

JPNC

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Granulosa cell tumors (GCT) are rare tumor and they constitute only 2% of all ovarian tumor. They are categorized in to juvenile and adult types. Juvenile Granulosa cell tumors only contribute to 5% of all GCT and they usually affect young children and premenarchal girls. These tumor are mainly hormone producing and mostly present with signs of precocious puberty. However other clinical presentation like acute abdomen or abdominal distention has also been reported. Here we present a 2 years old girl who reported to us with complaints of progressive abdominal distention and urinary retention. Her tumor markers were negative and her ultrasound and CT with contrast showed a massive abdominal ascites and complex ovarian mass. Exploration and left salpingoopherctomy with ascitic fluid sampling done. Her ascitic fluid was negative for tumor cell. To our knowledge it is a unique case in which stage 1A co-existed with ascites fluid negative of tumor cells.

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Juvenile Granulosa and Theca Cell Tumor of the Ovary as a Rare Cause of Precocious Puberty: Case Report and Review of Literature

Cited by 22 publications

References 16 publications

Diagnosis and Management of Pelvic Masses in Children and Adolescents

Diagnosis and Management of Pelvic Masses in Children and Adolescents

Gynecological cancer among adolescents and young adults (AYA)

Ascites as a Sole Presentation of Juvenile Granulosa Cell Tumor

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