Juvenile fibromyalgia syndrome: Blunted heart rate response and cardiac autonomic dysfunction at diagnosis

Maia, Magda Maria; Gualano, Bruno; Sá-Pinto, Ana Lúcia de; Sallum, Adriana Maluf Elias; Pereira, Rosa Maria Rodrigues; Len, Cláudio Arnaldo; Terreri, M. T.; Barbosa, Cássia Maria Passarelli Lupoli; Roschel, Hamilton; Silva, Clóvis A.

doi:10.1016/j.semarthrit.2016.07.002

Cited by 18 publications

(19 citation statements)

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“…While there is a study showing that FM patients have similar cardiovascular responses to submaximal exercise as healthy control subjects [45], other new studies reported that FM patients had higher HR [27] and impaired cardiac function [28]. Further, they seem to have a higher risk of coronary heart disease-related events [29] and delayed HR recovery after a treadmill graded gait exercise [46]. However, it could not be clear how these cardiovascular problems in FM patients relate to the exercise-induced cardiac arrhythmia and decrease of HR in FM model mice.…”

Section: Study Limitations and Clinical Applicationsmentioning

confidence: 99%

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

et al. 2020

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Background Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model. Methods To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed. First, three types of gait tests were performed before and after the reserpine injections as follows: (i) 5 minutes of free gait outside the water, (ii) 1 minute of free gait in shallow warm water, and (iii) 5 minutes of free gait in shallow warm water. Second, electrocardiogram recordings were taken before and after the three gait tests. The average heart rate and heart rate irregularity scores were analyzed. Results Exercise-induced cardiac arrhythmia was observed at 1-minute gait in shallow water during the acute stage of induced FM in young mice. Further, both cardiac arrhythmia and a decrease in HR have occurred at 5-minute gait in shallow water at the same mice. However, this phenomenon was not observed in the wild-type mice under any test conditions. Conclusion Although a short-term free gait in shallow warm water may be advantageous for increasing the motor activity of FM-model mice, we should be aware of the risk of prolonged and excessive exercise-induced cardiac arrhythmia. For gait exercises in shallow water as a treatment in FM patients. We suggest a gradual increase in exercise duration may be warranted.

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Section: Study Limitations and Clinical Applicationsmentioning

confidence: 99%

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

et al. 2020

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“… 4 , 5 , 6 , 7 , 8 , 9 The use of digital media (computer, internet, electronic devices, and cell phones) is a risk factor for musculoskeletal pain and musculoskeletal pain syndromes in healthy and obese adolescents. 9 , 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Idiopathic musculoskeletal pain, musculoskeletal pain syndromes, and use of electronic devices in adolescents with asthma

Nastri

Lourenço

Queiroz

et al. 2022

Jornal de Pediatria

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“…The etiopathogenesis of amplified musculoskeletal pain syndromes is multifactorial and includes physical factors such as lower central pain threshold, increased nociceptive receptor sensitivity, autonomic nervous system disorders [3], emotional factors such as increased stress and anxiety and environmental aspects [4]. In some patients, there may be other clinical findings related to pain, such as joint hypermobility and obesity, among others [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Gait in children and adolescents with idiopathic musculoskeletal pain

et al. 2019

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Introduction: Musculoskeletal pain is a constant complaint in pediatric practice. The pain may be related to a number of organic diseases and / or be part of the amplified musculoskeletal pain syndromes. Idiopathic musculoskeletal pain (IMSP) is defined as the presence of intermittent pain in three or more body regions for at least three months, excluding organic diseases that could explain the symptoms. Objective: To study the gait of children and adolescents with IMSP by dynamic baropodometry.Methodology: Thirty-two patients with IMSP and 32 healthy controls, matched by age, sex, social class, and body mass index (BMI) were enrolled. All were evaluated for pain intensity through the visual analogue scale (VAS) and gait evaluation using dynamic baropodometry. Results: The mean age of the IMSP group was 13.6 years (SD = 2.1, range 9.8-16.9) and of the control group was 13.5 years (SD = 2.0, range 9.6-16.5). The mean pain scale was 5.4 cm in the IMSP group and 0 cm in the control group (p < 0.001). In gait, the mean right foot velocity of the IMSP group was significantly lower (p = 0.034), the time of the step of the IMSP group was significantly higher (p = 0.003) and the pace of the IMSP group was significantly lower (p = 0.001). Conclusion: In our study we observed differences between the gait of children with IMSP and healthy controls according to the dynamic baropodometry. This finding indicates the need for individualized attention to the gait of children with musculoskeletal pain.

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Juvenile fibromyalgia syndrome: Blunted heart rate response and cardiac autonomic dysfunction at diagnosis

Cited by 18 publications

References 44 publications

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

Idiopathic musculoskeletal pain, musculoskeletal pain syndromes, and use of electronic devices in adolescents with asthma

Gait in children and adolescents with idiopathic musculoskeletal pain

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