Juvenile chronic arthritis into adulthood: a long‐term follow‐up study

Abstract

Although the study group was biased towards the more severe cases, the data suggest that the long-term functional outcome in JCA is, in more than one-third, associated with active disease persisting into adulthood, increasing residua and the need for surgery.

Seguimento do estado de remissão de crianças com artrite idiopática juvenil

“…8,10,21 Uveitis was related to the prevalence of ANA, which, in our study, was 10.2%, well below the 66% reported by Wallace et al 20 and the 46.1% described by Zak & Pederson, 11 but comparable with results published by Arguedas 22 for Latin American patients. The antigens…”

“…8,[11][12][13][14]20,28 Guilhaume et al 28 studied the oligoarticular form, finding that more than 100 mm in the first hour of ESR, more than one affected joint and upper limb involvement were predictive of a change in course from persistent to extended oligoarticular JIA. Just 23% of their patients attained CR, 50% progressed to the extended oligoarticular form, 35% exhibited articular erosion and 30% exhibited uveitis.…”

“…There are many studies that demonstrate that patients with JIA reach adulthood with active arthritis, at percentages varying from 20 to 60% of cases, depending on the study realized. 10,11,29 More common among patients with extended oligoarticular or polyarticular forms, 11 many persisted with limitations to their day-to-day activities 15 and exhibited severe functional disability assessed by the Health Assessment Questionnaire (HAQ), 10 varying from 37 to 43% 20 Oen et al 13 Minden et al 8 Mean duration of follow-up 3. depending on the study. Physical and emotional sequelae are observed among adolescents and adults with persistent disease activity.…”

“…3 Treatment is complex and has undergone major changes during the last ten years, [4][5][6] Cohort studies evaluating JIA prognosis indicate that many children suffer disease activity that lasts into adulthood. [8][9][10][11][12][13][14][15] Using the most recent advances in treatment, periods of inactivity have also been observed, which may then progress to remission or relapse. 16 A consensus on the criteria for JIA remission was reached recently, [16][17][18] defining different criteria from those for adults.…”

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort

“…Numerous previous studies have examined the outcomes of chronic childhood arthritis, but their applicability and utility for patients seen currently is limited by several considerations (1)(2)(3)(4)(5)(6)(7)(8)(9). For example, the use of a variety of classification systems, including the American College of Rheumatology (ACR) and the European League Against Rheumatism criteria and different diagnostic criteria for psoriatic arthritis (PsA) or seronegative spondylarthritides in children, resulted in heterogeneous patient subgroups (10 -15).…”