Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort

Oen, Kiem; Duffy, Ciarán M.; Tse, Shirley M. L.; Ramsey, Suzanne; Ellsworth, Janet; Chédeville, Gaëlle; Chetaille, Anne-Laure; Saint-Cyr, Claire; Cabral, David A.; Spiegel, Lynn; Schneider, Rayfel; Lang, Bianca; Huber, Adam M.; Dancey, Paul; Silverman, Earl D.; Rosenberg, Alan; Cameron, Bonnie; Johnson, Nicole; Dorval, Jean; Scuccimarri, Rosie; Campillo, Sarah; Petty, Ross E.; Duffy, Karen N Watanabe; Boire, Gilles; Haddad, Élie; Houghton, Kristin; Laxer, Ronald M.; Turvey, Stuart E.; Miettunen, Päivi; Gross, Katherine; Guzman, Jaime; Benseler, Susanne M.; Feldman, Brian M.; Espinosa, V.; Yeung, Rae S. M.; Tucker, Lori B.

doi:10.1002/acr.20044

Cited by 91 publications

(59 citation statements)

References 23 publications

(22 reference statements)

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“…Arthritis rapidly resolved in all our patients at the initiation of anakinra. This compares favourably with several reported studies where arthritis persisted in 36-63% of children with SJIA during 6-9 months follow up [7,11,37,38]. Furthermore, Nigrovic et al reported persistent arthritis in 15% of their 34 studied population after a follow up of 7-8 months necessitating the addition of corticosteroids in 30 % of their population [15].…”

Section: Discussionsupporting

confidence: 77%

First line therapy by Interleukin-1 teceptor antagonist in steroid naive children with systemic juvenile idiopathic arthritis

Daghistani¹,

Freychet²,

Pillet³

et al. 2017

Ann Paediatr Rheum

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Section: Discussionsupporting

confidence: 77%

First line therapy by Interleukin-1 teceptor antagonist in steroid naive children with systemic juvenile idiopathic arthritis

Daghistani¹,

Freychet²,

Pillet³

et al. 2017

Ann Paediatr Rheum

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“…The ReACCh-Out study has been previously described (21,22). Briefly, the study recruited consecutive patients newly diagnosed with JIA at all pediatric rheumatology centers in Canada between January 2005 and December 2010.…”

Section: Methodsmentioning

confidence: 99%

“…Demographic and clinical information and quality of life measures were collected at up to 8 study visits scheduled at 6-month intervals to 2 years and then yearly up to 5 years. Treatments were prescribed at the discretion of the attending pediatric rheumatologist in consultation with the family (21,22). The study was approved by research ethics boards at participating institutions and was carried out in conformity with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Health‐Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis

Oen

Guzman

Dufault

et al. 2017

Arthritis Care & Research

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Objective. To describe changes in health-related quality of life (HRQoL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes, and to identify predictors of unfavorable HRQoL trajectories. Methods. Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), healthrelated Quality of My Life (HRQoML, an instrument based on personal valuations), and JIA core variables were completed serially. Analyses included median values, Kaplan-Meier survival curves, and latent trajectory analysis. Results. A total of 1,249 patients enrolled at a median of 0.5 months after diagnosis were followed for a median of 34.2 months. The degree of initial HRQoL impairment and probabilities of reaching the best possible HRQoL scores varied across JIA categories (best for oligoarthritis, worst for rheumatoid factor-positive polyarthritis). Median times to attain best possible HRQoL scores (JAQQ 59.3 months, HRQoML 34.5 months), lagged behind those for disease activity, pain, and disability measures. Most patients followed trajectories with minimal or mild impairment; however, 7.6% and 13.8% of patients, respectively, followed JAQQ and HRQoML trajectories with persistent major impairment in HRQoL. JIA category, aboriginal ethnicity, and baseline disease activity measures distinguished between membership in trajectories with major and minimal impairments. Conclusion. Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a measure based on respondents' preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.

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“…Enthesitis may not parallel the activity of or respond as well to therapy as arthritis (5). Untreated enthesitis may cause osteopenia, erosions, soft tissue calcifications, and new bone formation (6,7).…”

Section: Introductionmentioning

confidence: 99%

Enthesitis in an inception cohort of enthesitis‐related arthritis

Weiss¹,

Klink²,

Behrens³

et al. 2011

Arthritis Care & Research

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Objective. To describe an enthesitis-related arthritis (ERA) inception cohort and determine which entheses and joints are most commonly affected. Methods. We reviewed a retrospective inception cohort study of children with ERA who were diagnosed and treated at The Children's Hospital of Philadelphia between November 2007 and December 2009. Results. During the study period, there were 32 newly diagnosed ERA patients. Fifty-nine percent were male, and the median age at the date of initial evaluation was 12.5 years (interquartile range [IQR] 10.2-14.3 years). The median number of tender entheses at presentation was 2 (IQR 0 -5), and 21 subjects (66%) had at least 1 tender enthesis. The most prevalent tender entheses were the patellar ligament insertion at the inferior pole of the patella, the plantar fascial insertion at the calcaneus, the Achilles tendon insertion at the calcaneus, and the plantar fascial insertion at the metatarsal heads. Enthesitis was most often symmetric. The median number of active joints was 2 (IQR 0 -4). The most commonly affected joints were the sacroiliacs, knees, and ankles. Sacroiliitis, which was defined clinically, was most often symmetric, while peripheral arthritis was most frequently asymmetric. The odds of having active enthesitis at 6 months increased significantly with each additional tender enthesis at the initial evaluation. Conclusion. Among pediatric patients with ERA, lower extremity enthesitis is prevalent at the time of diagnosis and is likely to persist 6 months later. Future studies should address standardization of the enthesitis examination, the pattern of enthesitis over time, enthesitis response to therapy, and the impact of enthesitis on quality of life.

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Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort

Cited by 91 publications

References 23 publications

First line therapy by Interleukin-1 teceptor antagonist in steroid naive children with systemic juvenile idiopathic arthritis

First line therapy by Interleukin-1 teceptor antagonist in steroid naive children with systemic juvenile idiopathic arthritis

Health‐Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis

Enthesitis in an inception cohort of enthesitis‐related arthritis

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