Justification of the need for correction selenium status in the treatment of thyrotopathy among Ukrainians (review of literature and their own observations)

Гончарова, О.А.

doi:10.31793/1680-1466.2018.23-4.362

Cited by 2 publications

(4 citation statements)

References 44 publications

(46 reference statements)

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“…Therefore, irrespective of the presence or absence of AO, most patients with GD exhibited severe Se deficiency, which requires administration of selenium agents. These findings are in agreement with those reported by other studies on selenium deficiency in thyroid disorders in Ukraine, with severe selenium deficiency observed in patients with autoimmune thyroid disorders [17].…”

Section: Resultssupporting

confidence: 93%

“…In addition, Se deficiency can exacerbate the effects of iodine deficiency and the same is true for vitamin A or iron deficiency [15,16]. Se deficiency has shown to be a key environmental factor which is thought to precipitate autoimmune thyroid disease in several parts of the world deficient in soil Se [17]. The regulation and metabolism of thyroid hormones require a steady supply of Se, and environmental Se levels strongly correlate with serum Se levels [18,19].…”

Section: Introductionmentioning

confidence: 99%

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On selenium deficiency in Graves’ disease patients with autoimmune ophthalmopathy

Buldygina¹,

Terekhova²,

Fedko³

et al. 2019

Oftalmol Zh

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The role of selenium (Se) deficiency in the development of thyroid associated ophthalmopathy has been actively debated in the literature. The question is still debated in Ukraine due to the absence of data both on selenium deficiency in this country and blood selenium levels in Graves' disease patients with autoimmune ophthalmopathology (AO). Purpose: To investigate blood selenium levels in Graves' disease patients with AO. Materials and Methods: Fifty-seven Graves' disease patients were included in the study. Of these, 44 had AO. Clinical severity of AO was classified using the NOSPECS. Of the 44 patients with AO, 16, 19 and 9 patients had class 2b, class 3a or 3b, and class 4a, respectively. All patients were euthyroids receiving antithyroid therapy (mean TSH level, 1.36 ± 0.4 mIU/L; reference TSH range, 0.4 mIU/L to 4.0 mIU/L). A Hitachi MPF-2A fluorescence spectrophotometer was used to determine blood selenium levels. A blood selenium level between 75 and 120 μg/l was considered normal, between 50 and 75 μg/l was moderate Se deficiency, and <200 μg/l considered severe Se deficiency. Results: Of the 57 patients of both groups, 31 (54%) were found to be severely selenium deficient. The mean blood selenium level in Graves' disease patients with AO was 60.07±7.61 μg/l, i.e., substantially lower than the normal range. In addition, 34% of these patients had a normal blood selenium level, whereas 16% and 50%, moderate and severe Se deficiency, respectively. The mean blood selenium level in Graves' disease patients without AO was 34.4±10.2 μg/l, i.e., also substantially lower than the normal range. In addition, 31% of these patients had a normal blood selenium level, whereas 69%, severe Se deficiency. Conclusion: First, irrespective of the presence or absence of AO, 54% of Graves' disease patients were found to exhibit severe selenium deficiency. Second, the mean blood selenium level in Graves' disease patients with AO was 60.07 ± 7.61 μg/l, and 50% of them exhibited severe selenium deficiency. In addition, the mean blood selenium level in patients with Graves' disease only was 34.4 ± 10.2 μg/l, and 69% of them exhibited severe selenium deficiency. There was, however, no significant difference in blood selenium level between groups (Р > 0.05). Therefore, it may be assumed that selenium deficiency is not a factor affecting the development of AO in Graves' disease. Finally, given that fact that 34% of Graves' disease patients with AO exhibited no selenium deficiency, such patients should not be prescribed selenium agents without first checking their blood selenium levels.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

On selenium deficiency in Graves’ disease patients with autoimmune ophthalmopathy

Buldygina¹,

Terekhova²,

Fedko³

et al. 2019

Oftalmol Zh

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“…Even in such countries as Great Britain, the intake of selenium with food products has decreased by 50% [26]. By now, monitoring studies have been conducted in European countries, including Ukraine, which revealed a defi ciency of selenium in the population's diet [22,27,28].…”

mentioning

confidence: 99%

“…(повтор). At the same time, the defi ciency of selenium in the diet of the population has a global scale [15][16][17][18][19][20][26][27][28].…”

mentioning

confidence: 99%

Trace Elements Zinc and Selenium: Their Significance in the Conditions of the COVID-19 Pandemic

Gulich¹,

Yemchenko²,

Kaplinenko³

et al. 2023

Mikrobiol. Z.

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Within the conditions of the ongoing COVID-19 pandemic, when many questions regarding prevention and treatment strategies remain unsolved and the search for the best antiviral agents is underway, attention should be paid to the role of trace elements zinc and selenium in increasing the body’s resistance to viral infections and their direct antiviral activity against SARS-CoV-2. Experimental data show that trace elements zinc and selenium not only act through regulating the immune response at all levels of humoral and cellular immunity, but also can play a significant role in adjuvant therapy for viral diseases. This is especially relevant in the case of COVID-19. Studies of the direct antiviral effect of these microelements testify to its 3 main ways to SARS-CoV-2: I — counteraction to virus replication and its transcription through: (i) their covalent binding to the SH-group of the cysteine of the main protease M(Pro) of the virus; (ii) inhibition of its RNA polymerase activity by zinc; II — preventing the penetration of the virus into cells due to blocking SH-groups of protein disulfide isomerase (RDI) of the protein of its spikes (peplomers); III — decreasing the adsorption capacity of the virus due to the blocking of the electrostatic interaction of SARS-CoV-2 peplomers and angiotensin-converting enzyme (ACE-2) in ultra-low, uncharacteristic oxidation states (Zn+1 and Se-2). The intensity of the antiviral action of these trace elements may depend on their chemical form. It was found that zinc citrate (a five-membered complex of zinc with citric acid) and monoselenium citric acid obtained with the help of nanotechnology have a greater intensity of action and higher chemical purity. Taking into account the immunostimulating and direct antiviral effect of zinc and selenium, their use in the form of pharmaceuticals and dietary supplements should be considered as adjunctive therapy for SARS-CoV-2 in patients, or as a preventive strategy for uninfected people from risk groups during the spread of COVID-19.

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Justification of the need for correction selenium status in the treatment of thyrotopathy among Ukrainians (review of literature and their own observations)

Cited by 2 publications

References 44 publications

On selenium deficiency in Graves’ disease patients with autoimmune ophthalmopathy

On selenium deficiency in Graves’ disease patients with autoimmune ophthalmopathy

Trace Elements Zinc and Selenium: Their Significance in the Conditions of the COVID-19 Pandemic

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