Junctional CD8+ Cutaneous Lymphomas With Nonaggressive Clinical Behavior

Abstract

To evaluate the clinical and prognostic features in primary cutaneous CD8 + T-cell lymphomas, which are rare and considered to be aggressive cutaneous lymphoproliferative disorders.Design: Single-center retrospective study.Setting: Lymphoma clinic (referral center) of a university hospital.Patients: Three patients presented with CD8 + cutaneous lymphoma characterized by a patchlike pattern and hyperpigmentation.Results: Histological analysis revealed a CD3 + , CD8 + small-cell infiltrate showing a remarkable affinity to the dermoepidermal junction zone. Clonality for the T-cell receptor ␥ chain was detected by polymerase chain reaction followed by denaturing gradient gel electrophoresis. The clinical presentation lasted several years (6 and 9 years, respectively) before the correct diagnosis was made. Treatment with nontoxic approaches (UV-B and local steroids) was successful. Aggressive clinical behavior was not observed.Conclusions: Our 3 cases of junctional CD8 + cutaneous T-cell lymphomas were characterized by hyperpigmentation and nonaggressive clinical behavior. This type of lymphoma, which can be considered a CD8 + mycosis fungoides variant, must be distinguished from other types of cutaneous CD8 + lymphomas so that overtreatment can be avoided.

Ichthyosiform Mycosis fungoides: Report of a Case Associated with IgA Nephropathy

“…Although Delfau-Larue et al [18]describe that negativity of TCR-γ gene rearrangements was a significant independent predictor of treatment response, many patients with ichthyosiform MF including ours who represented an excellent response to the treatment were found positive for TCR-γ gene rearrangements [3, 8]. In cases with an infiltrate of CD8+ predominant lymphocytes, the disease was described as being rapidly progressive [16], whereas others found no aggressive clinical behavior [19]. Taken together, accumulation of cases is necessary to conclude that ichthyosiform MF is a benign variant of MF.…”

Fatal CD8+ Epidermotropic Cytotoxic Primary Cutaneous T-Cell Lymphoma with Multiorgan Involvement

“…It is noteworthy that the systemic spread usually does not involve the superficial lymph nodes but involves various unusual sites, such as the oral cavity, lungs, testis and/or the central nervous system (CNS) [1, 2]. On the other hand, it is well known that ‘common’ mycosis fungoides (MF) may present with a CD8+ phenotype, especially in children [3, 4]. …”

CD8-positive mycosis fungoides: a case report

“…Az immunhisztológiai vizsgálat során megállapított CD8+ fenotípus az MF igen ritka variánsa, egyes irodalmi adatok szerint az összes MF eset kevesebb, mint 5%-át teszi ki (10), bár ez az incidencia nem egészen megbízható, hiszen sok esetben csak mint CD8 pozitív CTCL egyéb formája került közlésre (11). Az ezredfordulón vált világossá, hogy a CD8 pozitív CTCL egy igen heterogén csoport, a hasonló immunfenotípussal bíró kórképek tünetei és lefolyása is nagy eltérést mutat (12,13). A 2008-as WHO klasszifikációban külön, provizórikus entitásként osztályozták az Emilio Berti által leírt primer cutan CD8+ agresszív epidermotrop cytotoxikus T-sejtes lymphomát (14,15), mely igen rossz prognózisú kórkép, szemben a közölt CD8+ MF esetek többségével (13,16,17).…”