Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy

Roh, Seung-Eon; Jeong, Yideul; Kang, Myeong-Ho; Bae, Yong-Soo

doi:10.1016/j.canlet.2018.07.029

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Previous studies indicated that JAML plays an important role in γδ T cell activation and tissue homeostasis [ 27 , 28 ]. JAML was also identified as a crucial component of DC migration and can promote response to DC-based cancer immunotherapy [ 29 ]. Similarly, our study demonstrated the significant association between JAML and the tumor immune microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma

Fang

et al. 2021

Med Sci Monit

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Background Junctional adhesion molecule-like protein (JAML) is a member of the junctional adhesion molecule family and mediates migration of immune cells, but its function in cancers remains unclear. This study aimed to evaluate the role of JAML in the prognosis and immune infiltrates of lung adenocarcinoma (LUAD). Material/Methods JAML expressions in LUAD tissues and normal tissues were compared using The Cancer Genome Atlas (TCGA) database and datasets from the Gene Expression Omnibus (GEO) database. The influence of JAML expression on prognosis was analyzed by Kaplan-Meier curve and Cox regression model. Interactive and functional analyses of JAML were performed by LinkedOmics and GeneMANIA databases. TIMER2.0, TISIDB, and GEPIA2 databases were used to investigate the correlation between JAML expression and immune infiltrates. Results JAML expression was decreased in LUAD ( P <0.001), and lower JAML expression was associated with worse outcomes of LUAD patients. High JAML expression was the protective factor for overall survival (OS) (HR 0.706, 95% CI 0.500–0.997, P =0.048). Interactive and functional analyses suggested that co-expressed genes with JAML have an obvious link to immune-related pathways. In addition, JAML expression was positively associated with infiltrating levels of CD8+ T cells, CD4+ T cells, B cells, dendritic cells, macrophages, and neutrophils, and had significant correlations with diverse immune marker sets in LUAD. Conclusions JAML expression was significantly correlated with prognosis and immune infiltrates. These preliminary findings suggested JAML could be considered as a potential prognostic biomarker and therapeutic target for LUAD.

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Section: Discussionmentioning

confidence: 99%

Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma

Fang

et al. 2021

Med Sci Monit

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“…SIT1 regulates the proliferation, activation and survival of memory T cells, thus affecting the generation of regulatory T cells, the immune escape of tumors and the resistance of tumors to immunotherapy [34]. JAML is involved in the proliferation and survival of T cells, as well as the production and release of cytokines and growth factors; thus, JAML regulates the sensitivity of tumor cells to relevant vaccines [35].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment

Bai

Jin

Zhang

et al. 2019

Aging

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In the microenvironment of breast cancer, immune cell infiltration is associated with an improved prognosis. To identify immune-related prognostic markers and therapeutic targets, we determined the lymphocyte-specific kinase (LCK) metagene scores of samples from breast cancer patients in The Cancer Genome Atlas. The LCK metagene score correlated highly with other immune-related scores, as well as with the clinical stage, prognosis and tumor suppressor gene mutation status (BRCA2, TP53, PTEN) of patients in the four breast cancer subtypes. A weighted gene co-expression network analysis was performed to detect representative genes from LCK metagene-related gene modules. In two of these modules, the levels of the co-expressed genes correlated highly with LCK metagene levels, so we conducted an enrichment analysis to discover their functions. We also identified differentially expressed genes in samples with high and low LCK metagene scores. By examining the overlapping results from these analyses, we obtained 115 genes, and found that 22 of them were independent predictors of overall survival in breast cancer patients. These genes were validated for their prognostic and diagnostic value with external data sets and paired tumor and non-tumor tissues. The genes identified herein could serve as diagnostic/prognostic markers and immune-related therapeutic targets in breast cancer.

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“…In JAM-A −/− mice, antibody treatment using anti-JAM-A antibody was shown to have no effect on the transendothelial migration of neutrophils (Corada et al, 2005;Khandoga et al, 2005). Recently Seung-Eon and colleagues reported a reduction in the transendothelial migration of bone marrow-derived dendritic cells following treatment with a junctional adhesion molecule (JAM)-Like (JAML) antibody (anti-JAML) (Roh et al, 2018). The above evidence demonstrates the important role played by JAMs in TEM, thus taken together JAMs could serve as a therapeutic target for metastasis control in neuroblastoma patients.…”

Section: Tight Junctionsmentioning

confidence: 96%

Role of endothelial cell junctions in transendothelial cancer cell migration. A review

Rabiu¹

2022

dujopas

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During metastasis, tumour cells must become migratory and travel towards a capillary within the tumour. They then degrade the matrix surrounding the pericytes and endothelial cells, insert themselves between endothelial cells, transverse the capillary wall, to then enter the blood stream. This process depends on the motile behaviour of the tumour cells as well as the role of endothelial cell-cell junctions, both including adherens junctions and tight junctions. Circulating tumour cells must next, adhere to the walls of the capillary at the site of secondary tumour formation. Here, they again traverse the capillary wall to enter tissues distant from the primary tumour. This review aim to discuss the basic architecture of the endothelial junctional complex as well as the role played by these components towards the transendothelial migration of cancer cells from the primary site to the secondary site. Proper understanding of the role played by each of these components could invariably lead to the development of novel adjuvant cancer chemotherapy.

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Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy

Cited by 6 publications

References 45 publications

Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma

Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma

Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment

Role of endothelial cell junctions in transendothelial cancer cell migration. A review

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