2017
DOI: 10.1016/j.coviro.2017.01.002
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Jumping species—a mechanism for coronavirus persistence and survival

Abstract: Zoonotic transmission of novel viruses represents a significant threat to global public health and is fueled by globalization, the loss of natural habitats, and exposure to new hosts. For coronaviruses (CoVs), broad diversity exists within bat populations and uniquely positions them to seed future emergence events. In this review, we explore the host and viral dynamics that shape these CoV populations for survival, amplification, and possible emergence in novel hosts.

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Cited by 124 publications
(130 citation statements)
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“…Successful cross-species transmission depends foremost on the virus' ability to bind and functionally use a receptor within an alternative host, causing the S protein to be the driver of CoV emergence. However, (changes in) non-S genes may codetermine virus emergence in novel hosts (63). Our data indicate that PDCoV has access to cells of an exceptionally diverse range of species by binding to an interspecies conserved domain on APN.…”
Section: S1 (B) -Mfc (µM)mentioning
confidence: 84%
“…Successful cross-species transmission depends foremost on the virus' ability to bind and functionally use a receptor within an alternative host, causing the S protein to be the driver of CoV emergence. However, (changes in) non-S genes may codetermine virus emergence in novel hosts (63). Our data indicate that PDCoV has access to cells of an exceptionally diverse range of species by binding to an interspecies conserved domain on APN.…”
Section: S1 (B) -Mfc (µM)mentioning
confidence: 84%
“…Coronaviruses (CoVs) are enveloped positive-sense RNA viruses that belong to the family Coronaviridae. They have been found in a wide variety of animals and can cause respiratory, enteric, hepatic and neurological diseases [1,2].…”
Section: Abstract Viral Metagenomics · Coronavirus · Infectious Broncmentioning
confidence: 99%
“…still occurring 6 years after its initial discovery (3). Coupled with recently discovered SARS-and MERS-like coronaviruses circulating in animal populations, the threat of a coronavirus fueled outbreak remains far from remote (4). With this in mind, strategies must be developed to rapidly respond to a potential CoV emergence or reemergence event.…”
mentioning
confidence: 99%