Jugular Venous Hemodynamic Changes with Aging

Chung, Chih‐Ping; Lin, Ya-Ju; Chao, A-Ching; Lin, Shing‐Jong; Chen, Yen‐Yu; Wang, Yuh-Jen; Hu, Han‐Hwa

doi:10.1016/j.ultrasmedbio.2010.07.006

Cited by 55 publications

(61 citation statements)

References 34 publications

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“…A recent study that investigated IJV changes with aging in HCs found a decreased proportion of venous drainage and increased IJV reflux prevalence in older subjects. 27 In the present study, a trend toward a higher prevalence and number of extraluminal abnormalities was found in patients with MS compared with HCs on DS, whereas more patients with progressive-versus-nonprogressive MS presented with those anomalies. The presence of an annulus was not detected, contrary to previously reported results.…”

Section: Discussionsupporting

confidence: 50%

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Dolić

Marr²,

Valnarov³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the main extracranial cerebrospinal venous routes that interfere with normal venous outflow. Research into CCSVI will determine its sensitivity and specificity for a diagnosis of MS, its prevalence in MS patients, and its clinical, MRI, and genetic correlates. Our aim was to investigate the prevalence and number of intra-and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs.

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Section: Discussionsupporting

confidence: 50%

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Dolić

Marr²,

Valnarov³

et al. 2011

AJNR Am J Neuroradiol

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“…A recent study that investigated internal jugular vein changes with aging in HCs found a decreased proportion of venous drainage and increased internal jugular vein reflux prevalence in older subjects. 36 Even more recently, the same group of investigators showed that subjects with severe internal jugular vein reflux had more severe age-related WM changes on MR imaging, especially in caudal brain regions. 37 Therefore, the effect of CCSVI-related abnormalities in relation to WM changes in the brain parenchyma has to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

No Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis

Zivadinov

Cutter

Marr

et al. 2012

AJNR Am J Neuroradiol

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“…The origin of CVHAs has not yet been determined. It has been suggested that they may be physiological (Doepp et al, 2008;Baracchini et al, 2011), agingdependent (Chung et al, 2010(Chung et al, , 2011, congenital (Lee et al, 2010), or pathological. Taking into account that cerebral venous abnormalities have recently been described in CM (Fofi et al, 2012;De Simone et al, 2011), we hypothesized that the occurrence of sterile inflammation due to frequent migraine attacks, associated with abnormal venous circulation, might facilitate the deposition of iron in target brain structures and then favor the processes of migraine chronification.…”

Section: Discussionmentioning

confidence: 99%

Cerebral venous hemodynamic abnormalities in episodic and chronic migraine

Petolicchio¹,

Viganò²,

Biase³

et al. 2016

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SummaryAlterations of cerebral venous drainage have been demonstrated in chronic migraine (CM), suggesting that cerebral venous hemodynamic abnormalities (CVHAs) play a role in this condition. The aim of the present study was to look for a correlation between CM and CVHAs. We recruited 33 subjects suffering from CM with or without analgesic overuse, 29 episodic migraine (EM) patients with or without aura, and 21 healthy subjects as controls (HCs). CVHAs were evaluated by transcranial and extracranial echo-color Doppler evaluation of five venous hemodynamic parameters. CVHAs were significantly more frequent in the CM and EM patients than in the HCs. In the migraine patients, CVHAs were not correlated with clinical features. Cerebral venous hemodynamic abnormalities in episodic and chronic migraineThe significantly greater frequency of CVHAs observed in the migraineurs may reflect a possible relationship between migraine and these abnormalities. Prospective longitudinal studies are needed to investigate whether CVHAs have a role in the processes of migraine chronification. KEY WORDS: cerebral venous hemodynamic abnormalities, chronic cerebrospinal venous insufficiency, chronic migraine, migraine IntroductionChronic migraine (CM) is one of the most disabling primary headache forms (Lipton, 2009), whose underlying processes are not yet fully elucidated. It has been speculated that the development of CM involves pain facilitation processes (mediated by central sensitization mechanisms) that depend on the frequent repetition of the attacks (Schwedt, 2014). A high frequency of headache attacks and a long history of migraine have each been correlated with the accumulation of iron in the periaqueductal gray as well as in the red nucleus, putamen and globus pallidus (Welch et al., 2001;Kruit et al., 2009Kruit et al., , 2010. In view of the high iron content of these structures, it has been hypothesized that repeated hyperoxia could cause free radical cellular damage that might be identified by measuring cumulative iron sequestration in brain tissue (Welch, 2003;Nagesh et al., 2000). This 'iron hypothesis' might represent a mechanism able to explain the transition of the clinical phenotype from episodic migraine (EM) to CM (Welch, 2009). High levels of iron in brain tissue have also been found in other neurodegenerative and autoimmune diseases (Zamboni et al., 2007;Singh and Zamboni, 2009). In particular, in multiple sclerosis (MS) the deposition of iron has been correlated with the presence of venous insufficiency and with cerebral congestion (Zamboni et al., 2007;Singh and Zamboni, 2009). Taking into account that cerebral venous abnormalities have been recently described in CM (Fofi et al., 2012;De Simone et al., 2011), we hypothesize that the occurrence of sterile inflammation due to frequent migraine attacks, associated with abnormal venous circulation, might facilitate the deposition of iron in target brain structures and then favor the processes of migraine chronification. For this reason, we speculate

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Jugular Venous Hemodynamic Changes with Aging

Cited by 55 publications

References 34 publications

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

No Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis

Cerebral venous hemodynamic abnormalities in episodic and chronic migraine

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