Juglone Content in Leaf and Green Husk of Five Walnut (Juglans regia L.) Cultivars

Cosmulescu, Sina; Trandafir, Ion; Achim, G.; Baciu, A.

doi:10.15835/nbha3915728

Cited by 44 publications

(42 citation statements)

References 20 publications

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“…All cultivars showed statistically significant differences (p50.05) in contents on different sampling dates. Previous research (Cosmulescu et al, 2011) on juglone content in walnut leaves, by the end of vegetation period, showed that its content ranged between 5.42 and 22.82 mg/100 g in different cutivars. During growing season, there were oscillations of mean juglone content levels.…”

Section: Resultsmentioning

confidence: 94%

“…Juglone (5-hydroxynaphthoquinone) is known to be the characteristic compound of Juglans spp. (Juglandaceae) and is reported to occur in fresh walnut leaves (Cosmulescu et al, 2011;Nour et al, 2013), annual shoots and fruits Cosmulescu et al, 2010). Quantification of phenolic compounds in walnut leaves was performed by Amaral et al (2004) using HPLC-DAD which revealed that quercetin 3-galactoside was always the major compound while 4-pcoumaroylquinic acid was the minor one.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves

Cosmulescu¹,

Trandafir

Nour³

2013

Pharmaceutical Biology

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Section: Resultsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves

Cosmulescu¹,

Trandafir

Nour³

2013

Pharmaceutical Biology

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“…The development of parvulin inhibitors started with the use of juglone, an irreversible small molecule inhibitor . Juglone (5‐hydroxy 1,4‐naphthoquinone) is a component of walnut leaf extracts and inhibits parvulin PPIase family activity by modifying a sulphydryl group on the enzyme . It does not inhibit other PPIase family members and has been widely used to study the therapeutic potential of Pin1 inhibition .…”

Section: Development Of Ppiase Inhibitorsmentioning

confidence: 99%

“…83 Juglone (5hydroxy 1,4-naphthoquinone) is a component of walnut leaf extracts and inhibits parvulin PPIase family activity by modifying a sulphydryl group on the enzyme. 84 It does not inhibit other PPIase family members and has been widely used to study the therapeutic potential of Pin1 inhibition. 85,86 Unfortunately, juglone has been reported to have lack of specificity inhibiting other enzymes, including pyruvate decarboxylase and glutathione S-transferase.…”

Section: Development Of Ppiase Inhibitorsmentioning

confidence: 99%

Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Rostam

Piva

Babaahmadi‐Rezaei

et al. 2015

Clin Exp Pharma Physio

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SUMMARYPeptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different classes of PPIases and increasing interest in the development of specific PPIase inhibitors. Cyclosporine A, FK506, rapamycin and juglone are known PPIase inhibitors. Herein, we review recent advances in elucidating the role and regulation of the PPIase family in vascular disease. We focus on peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1), an important member of the PPIase family that plays a role in cell cycle progression, gene expression, cell signalling and cell proliferation. In addition, Pin1 may be involved in atherosclerosis. The unique role of Pin1 as a molecular switch that impacts on multiple downstream pathways necessitates the evaluation of a highly specific Pin1 inhibitor to aid in potential therapeutic drug discovery.

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“…11,12 US-AE offers a series of advantages such as improved efficiency, reduced extraction time and temperature. 13,14 There several reports on the ultrasound-assisted extraction of polyphenols from J. regia leaves. 11,15 On the other hand, there is no data on US--AE of total phenolics (TP) from J.nigra leaves.Many factors, such as solvent concentration, temperature and extraction time, have been determined to influence the US-AE efficacy of polyphenolic compounds from J. regia leaves.…”

mentioning

confidence: 99%

Optimization of ultrasound-assisted extraction of total polyphenolic compounds from Juglans nigra L. leaves

Gavrilović

Rajković

Simić

et al. 2018

JSCS

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The ultrasound-assisted extraction of Juglans nigra L. leaves was optimized with respect to total phenolic content (TP) of the extracts by varying the concentration of aqueous ethanol solution (E) and different solvent-to-solid ratio (S). The influence and optimum of the operating parameters (E and S) was examined using response surface methodology (RSM). The statistical criteria indicated the adequacy, reliability and precision of the developed RSM model. RSM showed that maximum extraction yield of TP 28.59 mg g -1 of draw plant was achieved at the optimal values of 50% E and 20 kg kg -1 S. Using the modelled optimized conditions, the detected relative difference between the predicted and the experimental yield was ±2.3 %. The determined TP content in the extracts varied from 12.54 to 29.26 mg GAE g -1 of dry plant indicated that J. nigra is a valuable source of phenolic substances. The extracts of J. nigra leaves obtained under optimal conditions showed good antioxidant activity (IC 50 = = 18.91±0.03 μg cm -3 ) which was determined by the scavenging effect on 2,2--diphenyl-1-picrylhydrazyl radical. The optimization of the TP extraction process is the important step in improving techno-economics of the potential commercial preparation of J. nigra extracts, as natural source of antioxidants.(CC) 2018 SCS.1274 GAVRILOVIĆ et al. ivity of black walnut, as well as ability of black walnut to depress the tumour growth rate and to prevent lead induced testicular toxicity in rats. [2][3][4][5] The polyphenolic compounds, important parameters in assessing the quality of numerous natural products, are responsible for beneficial health effect these products exhibit. 6 The polyphenolic profiles of bark, sapwood and heartwood, leaves and husks from J. nigra were characterized using different polyphenols (juglone, α-hydrojuglone-4-glucoside, myricetin, myricitrin, sakuranetin, sakuranin, neosakuranin and o-diphenols). [7][8][9] The extraction of polyphenolic compounds from Juglans species has been carried out with methanol and ethanol as solvents. [10][11][12] In recent years two extraction methods such as ultrasound-assisted (US-AE) and microwave-assisted extractions have been used for the extraction of polyphenolic compounds from the leaves of Juglans species. 11,12 US-AE offers a series of advantages such as improved efficiency, reduced extraction time and temperature. 13,14 There several reports on the ultrasound-assisted extraction of polyphenols from J. regia leaves. 11,15 On the other hand, there is no data on US--AE of total phenolics (TP) from J.nigra leaves.Many factors, such as solvent concentration, temperature and extraction time, have been determined to influence the US-AE efficacy of polyphenolic compounds from J. regia leaves. 11 Optimization of ultrasound extraction and simultaneous microwave/ultrasonic-assisted extraction of phenolic compounds from J. regia was assessed. 11,16 Despite the interesting properties of J. nigra and its extracts, there is lack of data regarding the optimal conditions for the pol...

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Juglone Content in Leaf and Green Husk of Five Walnut (Juglans regia L.) Cultivars

Cited by 44 publications

References 20 publications

Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves

Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves

Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Optimization of ultrasound-assisted extraction of total polyphenolic compounds from Juglans nigra L. leaves

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