Juárez

Hernández, Jorge F.; Revueltas, Silvestre Villegas; Padilla, Ignacio; Hernández, Adriana Gutiérrez; León, José Antonio González de

doi:10.2307/j.ctt1j5dr8j

Cited by 7 publications

(3 citation statements)

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“…Other work has explored the gallium complexes of DFO-conjugates for their antibiotic potency, producing complexes with highly strain-specific activity. 30 Efforts to elucidate the exact mechanism of action of Ga(III) in P. aeruginosa have recently been reported using pull-down methods for protein-bound Ga(III) with open sites of coordination. 31 In addition to the Ga(III) complexes providing an alternative, medicinal inorganic chemistry approach to the management of bacterial infections, the nuclear complexes utilizing radioactive isotopes 67 Ga 3+ (t 1/2 = 3.3 d, single photon emission computed tomography, SPECT) and 68 Ga 3+ (t 1/2 = 1.1 h, positron emission tomography, PET) also offer opportunities to explore nuclear imaging as a diagnostic tool.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency

et al. 2019

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Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using smallmolecular chelators, siderophores. Here, we introduce and assess the gallium(III) complex of ciprofloxacin-functionalized desferrichrome (D2) as a potential therapeutic for bacterial infection using an in vitro assay and radiochemical, tracer-based approach. Ga-D2 exhibits a minimum inhibitory concentration of 0.23 μM in Escherichia coli, in line with the parent fluoroquinolone antibiotic. Competitive and mutant strain assays show that Ga-D2 relies on FhuA-mediated transport for internalization. Ga-D2 is potent against Pseudomonas aeruginosa (3.8 μM), Staphylococcus aureus (0.94 μM), and Klebsiella pneumoniae (12.5 μM), while Fe-D2 is inactive in these strains. Radiochemical experiments with E. coli reveal that 67 Ga-D2 is taken up more efficiently than 67 Ga-citrate. In naive mice, 67 Ga-D2 clears renally and is excreted 13% intact in the urine. These pharmacokinetic and bacterial growth inhibitory properties qualify Ga-D2 for future investigations as a diagnosis and treatment tool for infection.

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Section: Introductionmentioning

confidence: 99%

Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency

et al. 2019

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“…The film thickness was kept constant (170 nm) for all prepared films. The film thickness was measured by using a constructed home-made interferometer based on Michelson's interferometer [33,34].…”

Section: Methodsmentioning

confidence: 99%

Optical properties of Se–Te–Sb thin films

El-ShazlyO.

SweyllamA.

2014

Can. J. Phys.

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Amorphous thin films of Se 80 Te (20-X) Sb X (X = 0, 4, 8, and 10 at. %) were deposited onto clean quartz substrates by vapour deposition (thermal evaporation) under a vacuum of 10 −5 Torr. The transmission spectra at normal incidence in the spectral range of 250-2500 nm were measured at room temperature. The optical energy gap E g was found to be indirect. The value of E g was found to decrease from 1.69 to 1.43 eV with increasing Sb content. The composition dependence of the optical energy gap is discussed in terms of the chemical bond approach. The band tail width of localized states E e was found to increase from 0.0297 to 0.0551 eV with increasing Sb content. PACS Nos.: 81.15.-z, 78.20.-e, 77.84.Bw.Résumé : Nous déposons des films minces de Se 80 Te (20-X) Sb X (X = 0, 4, 8 et 10 at. %) sur des substrats de quartz et déposés par phase vapeur (évaporation thermique) sous un vide de 10 -5 Torr. Nous mesurons à la température de la pièce le spectre de transmission dans le domaine spectral de 250 à 2500 nm. Nous trouvons que la bande interdite est indirecte et que sa valeur, E g , décroît de 1.69 à 1.43 eV lorsque la concentration de Sb augmente. Nous analysons la dépendance sur la concentration de la bande interdite en utilisant l'approche par liaison chimique. Nous observons que la largeur de la queue de bande des états localisés E e augmente de 0.0297 à 0.0551 lorsque la concentration de Sb croît. [Traduit par la Rédaction]

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“…81 La respuesta de los censualistas para forzar el reintegro de los intereses al 5%, o, cuando no fuera posible, resarcirse con la subasta de las propiedades, fue recurrir a la vía judicial contra los deudores, con la salvedad de que el nuevo principio constitucional les obligaba a renunciar al fuero eclesiástico en tales asuntos y a sujetarse a la conciliación como cualquier otra persona o institución.…”

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Justicia conciliatoria durante el liberalismo hispano en el Perú: el caso de Huamanga

Vila¹

2012

Anu. estud. am.

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Juárez

Cited by 7 publications

References 0 publications

Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency

Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency

Optical properties of Se–Te–Sb thin films

Justicia conciliatoria durante el liberalismo hispano en el Perú: el caso de Huamanga

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