Journey of Alpinia galanga from kitchen spice to nutraceutical to folk medicine to nanomedicine

Ramanunny, Arya Kadukkattil; Wadhwa, Sheetu; Gulati, Monica; Vishwas, Sukriti; Khursheed, Rubiya; Paudel, Keshav Raj; Gupta, Saurabh; Porwal, Omji; Alshahrani, Saad; Jha, Niraj Kumar; Chellappan, Dinesh Kumar; Prasher, Parteek; Gupta, Gaurav; Adams, Jon; Dua, Kamal; Tewary, Devesh; Singh, Sachin Kumar

doi:10.1016/j.jep.2022.115144

Cited by 12 publications

(8 citation statements)

References 111 publications

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“…The most cultivated and well-known species of this group is probably A. galanga (L.) Willd (AG) [ 96 ]. It represents a key ingredient in nutraceutical and pharmaceutical products due to the numerous benefits of its phytoconstituents, such as anti-inflammatory, anticancer and antioxidant effects [ 99 ]. Zerumbone is one of these functional components.…”

Section: Natural Sources Of Zerumbonementioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

Sánchez-Ballester

Blázquez

2022

Plants

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Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.

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Section: Natural Sources Of Zerumbonementioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

Sánchez-Ballester

Blázquez

2022

Plants

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“…For instance, Alpinia purpurata is often used as an ornamental plant 2 . Alpinia galanga is one of the crucial ingredients for curries, and has been utilized as a flavoring in meat and soup preparations 1,3 . Almost Alpinia species are also extensively used as traditional medicines for various diseases such as indigestion, vomiting, gastralgia, etc 1 …”

Section: Introductionmentioning

confidence: 99%

Flavonoids from Alpinia vietnamica, and their cytotoxic, antioxidative, and α‐glucosidase inhibitory activities

Tra,

Hoa,

Linh

et al. 2024

Vietnam Journal of Chemistry

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Phytochemical research of the 80% EtOH whole plant extract of Alpinia vietnamica H.Ð. Tran, Luu & Skornick resulted in the isolation and structural elucidation of seven compounds 1–7, including two flavones quercetin‐3‐O‐α‐l‐rhamnosyl (1→2)‐α‐l‐rhamnoside (1) and diosmetin (2), three flavanones pinocembrin (3), alpinetin (4) and 5‐O‐methylnaringenin (5), and two chalcones cardamonin (6) and helichrysetin (7). The isolated compounds have shown biological effects at different levels. Two chalcones 6–7 showed cytotoxicity toward four cancer cell lines KB, MCF7, A549, and HepG2, especially compound 7 strongly inhibited the growth of A549 cancerous cells with the IC50 of 6.81 µm. Flavone 1 strongly exhibited antioxidative activity to scavenge DPPH radicals with the IC50 of 51.68 µm. Flavone 2 and flavanone 4 moderately inhibited enzyme α‐glucosidase with the IC50 values of 296.34–324.64 µm.

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“…The nanoparticle-based drug carrier system is one of the emerging drug delivery systems for the safe, effective, and controlled delivery of chemotherapeutic agents [37][38][39][40][41]. These nanocarriers have shown promising results in the delivery of potential anti-cancer agents, for example curcumin and boswellic acid, with increased bioavailability and efficacy and decreased toxicity profiles [42][43][44][45][46].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro

et al. 2022

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Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer, which is a leading cause of cancer-related deaths worldwide. Berberine is an isoquinoline alkaloid that is commercially available for use as a supplement for the treatment of diabetes and cardiovascular diseases. However, the therapeutic benefits of berberine are limited by its extremely low bioavailability and toxicity at higher doses. Increasing evidence suggests that the incorporation of drug compounds in liquid crystal nanoparticles provides a new platform for the safe, effective, stable, and controlled delivery of the drug molecules. This study aimed to formulate an optimized formulation of berberine–phytantriol-loaded liquid crystalline nanoparticles (BP-LCNs) and to investigate the in vitro anti-cancer activity in a human lung adenocarcinoma A549 cell line. The BP-LCN formulation possessing optimal characteristics that was used in this study had a favorable particle size and entrapment efficiency rate (75.31%) and a superior drug release profile. The potential mechanism of action of the formulation was determined by measuring the mRNA levels of the tumor-associated genes PTEN, P53, and KRT18 and the protein expression levels with a human oncology protein array. BP-LCNs decreased the proliferation, migration, and colony-forming activity of A549 cells in a dose-dependent manner by upregulating the mRNA expression of PTEN and P53 and downregulating the mRNA expression of KRT18. Similarly, BP-LCNs also decreased the expression of proteins related to cancer cell proliferation and migration. This study highlights the utility of phytantriol-based LCNs in incorporating drug molecules with low GI absorption and bioavailability to increase their pharmacological effectiveness and potency in NSCLC.

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Journey of Alpinia galanga from kitchen spice to nutraceutical to folk medicine to nanomedicine

Cited by 12 publications

References 111 publications

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Flavonoids from Alpinia vietnamica, and their cytotoxic, antioxidative, and α‐glucosidase inhibitory activities

Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro

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