Joint involvement in Mexican patients with ulcerative colitis: a hospital-based retrospective study

Abstract

The most frequent extra-intestinal manifestation in ulcerative colitis (UC) around the world is joint involvement. There are no previous data in Latin America that is about this aspect of disease; hence, the aim of this study was to determine the frequency and factors associated to joint involvement in Mexican patients with UC. A total of 295 patients with histological diagnosis of UC were studied, divided into two groups: (1) 154 cases with at least one joint affection (arthralgia, peripheral, or axial arthropathy (sacroilitis (SI) or ankylosing spondylitis (AS))) and (2) 141 controls that had never presented any joint involvement during the clinical course of UC. Demographic, clinical, and laboratory variables were collected from the clinical records, at the time of presentation of the joint involvement for the cases and with the last information available for controls. A total of 52.2% of the patients had joint involvement, which was also the most frequent extra-intestinal manifestation (EIM). The frequency of peripheral arthralgia was 46.8% and of axial arthropathy was 5.4% (2.7% AS, 2.4% SI, and 0.3% both). The female gender (P = 0.01, OR = 3.061 95% CI: 1.311-7.15), elevated erythrocyte sedimentation rate (ESR) (P = 0.07, OR = 8.04 95% CI: 1.759-36.764), and moderate disease activity by Truelove and Witts criteria (P = 0.024, OR = 4.37 95% CI: 1.211-15.78) were factors associated at the time of presentation of the joint affection. Joint involvement is the most frequent EIM in Mexican patients with UC. The female gender, elevated ESR, and disease activity are factors associated with its presentation.

Assessment of extraintestinal manifestations in inflammatory bowel diseases: A systematic review and a proposed guide for clinical trials

“…There were 15 interventional studies (14 open label (OL) trials [20][21][22][23][24][25][26][27]30,32,33,36,49,50 and one randomised controlled trial (RCT) 42 ) and 30 non interventional studies (12 retrospective cohort studies, 28,31,45,48,52,54,[56][57][58][59][60][61] 10 case reports, 18,19,35,38-41, 43,44,47 four prospective cohort studies 4,29,37,55 and four case control studies). 34,46,51,53 A Jadad score ¼ 4 was assigned to the RCT. 42 Among the studies evaluated through the NOS scale there were four low (8.9%), 19,35,39,43 15 moderate (33.3%) 18,21,23,25,30,33,38,…”

“…34,46,51,53 A Jadad score ¼ 4 was assigned to the RCT. 42 Among the studies evaluated through the NOS scale there were four low (8.9%), 19,35,39,43 15 moderate (33.3%) 18,21,23,25,30,33,38,40,41,44,45,[47][48][49][50] and 25 high quality studies (55.6%) 4,20,22,24,[26][27][28][29]31,32,34,36,37,46,[51][52][53][54][55][56][57][58][59][60][61] ( Supplementary Material Tables 1 and 2).…”

Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs

“…Articular disease has been further independently associated more with CD than UC [5], with female gender [94, 95], with older age [89], and with smoking [90].…”

Gancao Xiexin decoction combined with mesalazine in the treatment of ulcerative colitis

“…So far, the etiology and pathophysiology of UC remain unclear, the symptoms of UC not only include gastrointestinal symptoms, such as bloody diarrhea, abdominal pain, fecal urgency, and/or tenesmus, [ 5 ] but also include extraintestinal manifestations such as joint, eyes, skin mucosa, hepatobiliary, and bone. [ 6 ] The objectives for UC are clinical and endoscopic remission for induction and maintenance. Patients of UC may be up to more than 10 bowel movements during onsets of the disease, thus strongly affecting the quality of life, [ 7 ] this is being a huge burden of health and economy for patients themselves and countries as well, even become an important public health problem worldwide.…”