Gancao Xiexin decoction combined with mesalazine in the treatment of ulcerative colitis

Abstract

Backgroud: Ulcerative colitis (UC) is a chronic inflammatory disease that involves the rectum, colon and ileum. Gancao Xiexin decoction (GCXXD) is a classic herbal formula in Shanghanlun. More and more research evidence shows that GCXXD has a certain therapeutic effect on UC. Therefore, we designed this study protocol aim to evaluate the efficacy and safety of GCXXD combine with mesalazine for UC. Methods: We will systematically search 6 databases, including PubMed, the Cochrane Library, EMBASE, CNKI, VIP, Wang-fang database up to July 2020 to obtain eligible studies. The primary outcomes will focus on the clinical effectiveness. Review Manager 5.3 software will be used for data analysis. Results: This study will provide the systematic evidence of UC treated with GCXXD combine with mesalazine. Conclusion: The findings of this meta-analysis will provide evidence to judge whether GCXXD combine with mesalazine is a more effective intervention compare to mesalazine only for patient of UC. INPLASY registration number: INPLASY202080008.

Systematic review with meta-analysis: effectiveness of hyperbaric oxygenation therapy for ulcerative colitis

“…Thirteen studies were finally included for statistical analysis. [13][14][15][16][17][18][19][20][21][22][23][24][25] Characteristics of the articles All included studies were RCTs. A total of 780 patients were included with 397 patients in the intervention group (Tables 1 and 2).…”