“…Although an inflammatory component is rare, EDS-HT carries a high potential for disability13 due to recurrent dislocations and subluxations and chronic pain 8,11,12,14,15. Throughout the years, extra-articular manifestations have been described, including cardiovascular and autonomic nervous system,16–22 gastrointestinal,19,23 hematologic,24–26 ocular,27 gynecologic,19,28–31 neurologic,19,25,32,33 and psychiatric manifestations,7,8,11,19,34,35 emphasizing the multisystemic nature of EDS-HT. Unfortunately, EDS-HT is under-recognized and inadequately managed,36–38 leading to neglect of these patients which may lead to severe disability that almost certainly could have been avoided 39…”