Systemic Manifestations of Ehlers-Danlos Syndrome Hypermobility Type

Abstract

Ehlers-Danlos syndrome Hypermobility type is a hereditary connective tissue disease characterized by generalized joint Hypermobility, joint instability, skin changes and musculoskeletal pain. Signs and symptoms of Ehlers-Danlos syndrome Hypermobility type are classified as musculoskeletal or extra skeletal. Pain and fatigue are the most common complaints in the clinical practice. Due to impaired postural structure and biomechanics, associated conditions include nocturnal insomnia and early morning drowsiness, dysautonomia, dyslexia and neuropsychological disorders and illnesses related to impaired restorative phases of sleep. The patient has musculoskeletal pain that affects the activities of daily life and work, as well as shifting the biological clock. It is therefore important to understand the order of appearance and prevalence of signs and symptoms in the general population suggesting a need to investigate the order of these symptoms in population studies.

Detecting Ehlers-Danlos Syndrome Early in Life Is an Urgent Priority

“…This situation is particularly devastating in Ehlers-Danlos disease, which has not been taught to doctors, and is expressed by mainly subjective signs, of which anxiety and imaginative creativity are part. Clinicians [5][6][7][8][9] have progressively regrouped, on large series of patients, clinical criteria which, by their singular association, allow the diagnosis: intense fatigue, diffuse pain, disruption of motor control by dysproprioception and dystonia, skin fragility, joint hypermobility, hemorrhage, hyperacusis, gastric reflux, autonomic dysfunction. These clinical signs' expression is variable evolving on a permanent background with episodes of crisis triggered by activity, trauma, hormonal factors (pregnancies, periods, menopause), climate change.…”

Autism Spectrum Disorder and Ehlers-Danlos Syndrome - Hypermobility Type: A Case Report

“…The most common subtype is the hypermobility type (EDS-HT) and has systemic manifestations. Pain and fatigue are the most common complaints in the daily clinical practice 4 . According to Baeza-Velasco et al (2016) 5 , this subtype is reported in a range of 45% cases of EDS-HT in England 6 and 39% in Chile 7 , and the characteristic of JH alone is identified between 10% to 30% of the population worldwide 8 .…”

Untitled

“…A thorough knowledge of gastrointestinal (GI) manifestations and their management is mandatory to avoid unnecessary morbidity and mortality. [13][14][15] An increased rate of celiac disease was identified in EDS-HT, suggestive of intestinal malabsorption, a possible factor for fatigue. 16,17 Moreover, individuals have psychiatric disorders and psychosocial impairment, 18 and a high prevalence of anxiety disorders from simple phobias to panic disorders.…”