Joint Estimation for P-P and P-S Residual Statics

Meur, D. Le; Poulain, G.

doi:10.3997/2214-4609.20148119

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…This suggests that conflict resolution mechanisms and avenues remain unfocused and therefore weakens the capacity to deal with unresolved conflicts. Apart from competition among water users, persistent droughts, lack of strong institutions to manage equitable water use, political differences and biased property rights over access to land constitute other factors that have led to conflicts (Bond, 2014;Habiyakare and Zhou, 2015;Le Meur et al, 2006 Opiyo et al, 2012;Warurii, 2013). The data acknowledges the existence of other causes of water related conflicts such as latent conflicts over marginalization, political interference, corruption and ethnic profiling (Didier et al, 2011;Opiyo et al, 2012;Rahman, 2013).…”

Section: Resultsmentioning

confidence: 99%

Unresolved Water Conflicts by Water Sector Institutions in Ewaso Ng’iro North River Sub-Basin, Kenya

Lesrima¹,

Nyamasyo²,

Kiemo³

2021

jasem

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Water conflicts have huge impacts on livelihoods and without proper redress, have capacity to stall economic development of a community. This paper therefore explicates the impacts of unresolved water related conflicts in Ewaso Ng’iro North River sub-basin in Kenya and their persistence despite past major institutional and policy reforms in the water sector. Repetitive unresolved water conflicts curtail the prosperity of the communities on river basins. Study objective was to assess continued unresolved conflicts albeit the numerous and robust water reforms. Mixed methods research design was adopted to capture both primary and secondary data. Game Theory supported the study explicating how water users both upstream and downstream are players whose payoffs if not transparent cause conflicts. Sampling formula was utilized to derive a sample size of 384 respondents and employed simple random sampling. Primary data were collected through structured questionnaires, Key Informant interviews, Focused Group Discussions and Transect walks. Results show that water users aware of regulations in place governing water on river basins however had weak compliance. The legal and policy reforms need to be up scaled to enhance capacity to resolve conflicts by WRUAs and WRA. Compliance to regulations governing water to be enforced by mandated institutions to curb the repetitiveness of unresolved water conflicts. Keywords: Ewaso Ng’iro, Institutional reforms, Water Resources, Water Users, Unresolved Conflicts.

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Section: Resultsmentioning

confidence: 99%

Unresolved Water Conflicts by Water Sector Institutions in Ewaso Ng’iro North River Sub-Basin, Kenya

Lesrima¹,

Nyamasyo²,

Kiemo³

2021

jasem

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“…We also speculate that due to the presence of the carbonyl group in Lead1 as a key functional group in the interactions with the first sodium ion and the binding as a whole, as in the case of ALX1393, this inhibitor will be reversible and thus will not produce undesired toxic affects due to decreasing GlyT2 expression levels. 16 However, the calculated Lead2 ADMET profile was superior, indicating superior BBB penetration and no significant interactions with major proteins that can produce side effects. However, additional selectivity screening against the remaining members of these transporters and an additional optimization will be necessary.…”

Section: Lead1 Selectivity As Calculated By Fep+ and Admet Profilementioning

confidence: 97%

“…15 Several other drug candidates did not advance to clinical trials because either they had a poor ADMET profile (ALX1393) or were irreversible binders (Org-25543), producing serious toxic effects by decreasing GlyT2 expression. 16 Several drug candidates for schizophrenia, which inhibit GlyT1 homologs, failed for similar reasons. 17 This has given researchers the impression that GlyT1/2 are not relevant targets.…”

Section: Introductionmentioning

confidence: 99%

Discovery of New Classes of Glycine transporter 2 (GlyT2) Inhibitors and Study of GlyT2 Selectivity by Combination of Novel Structural Based Virtual Screening Approach and Free Energy Perturbation (FEP+) Calculations

Fratev

Miranda-Arango

Padilla

et al. 2019

Preprint

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In recent years, the mammalian GlyT2 transporter has emerged as a promising target for the development of anti-chronic pain agents. In our current work, we discovered a new set of promising hits that inhibit the glycine transport at nano and micromolar activity and have excellent selectivity over GlyT1 (as shown by in vitro studies), using a newly designed virtual screening (VS) protocol that combines a structure-based pharmacophore and docking screens. Furthermore, the free energy perturbation (FEP+ protocol) calculations and molecular dynamics (MD) studies revealed the GlyT2 amino acid residues critical for the binding and selectivity of both Glycine and our Lead1 compound. The FEP+ results well-matched available literature mutational data proving the quality of the generated GlyT2 structure. Based on these calculations we propose that Lead1 may also be a strong inhibitor of the neutral and basic amino acid transporter B (0+) (SLC6A14). Thus, the subsequent lead optimization and characterization of refined compounds may lead to both chronic pain and pancreatic cancer agents addressing an unmet and challenging clinical needs.

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“…El interés por las lenguas autóctonas emergió a mediados de 1970, con la llegada del régimen militar revolucionario, especialmente con el socialismo marxista-leninista en 1975. Posteriormente, por diversas razones, ese interés se vio favorecido desde 1991 a través de la democracia y la descentralización política debido al aumento del poder de las autoridades locales (Le Meur, 1995), como se refleja en este artículo: "Art. 99: El municipio debe garantizar la promoción de las lenguas nacionales a fin de usarlas en forma escrita y oral.…”

Section: Antecedentesunclassified

Multilingualism in Benin. Some Reflections from the Perspective of Sustainable Development and Multilingual Education

García-Azkoaga

Pérez-Caurel

2019

Sustainable Multilingualism

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Summary The article provides an overview of the state of the Bariba language on the Replublic of Benin (West Africa) and reflects on the urgent need to make effective the wishes of implementing a language policy that promotes a rigurous multilingual education of quality that helps preserve native languages. Through some visits to local schools of the Beninese Departments of Borgou and Alibori and through the language autobiographies of significant people from the Bariba language community of those departments, we highlight five reflections that underline the importance of multilingualism and point out the multilingual school as a key element for the preservation of intangible heritage, for social development and for achieving the sustainable development goals of the United Nations 2030 Agenda.

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Joint Estimation for P-P and P-S Residual Statics

Cited by 4 publications

References 4 publications

Unresolved Water Conflicts by Water Sector Institutions in Ewaso Ng’iro North River Sub-Basin, Kenya

Unresolved Water Conflicts by Water Sector Institutions in Ewaso Ng’iro North River Sub-Basin, Kenya

Discovery of New Classes of Glycine transporter 2 (GlyT2) Inhibitors and Study of GlyT2 Selectivity by Combination of Novel Structural Based Virtual Screening Approach and Free Energy Perturbation (FEP+) Calculations

Multilingualism in Benin. Some Reflections from the Perspective of Sustainable Development and Multilingual Education

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