Joint effects of serum ferritin and body mass index on the risk of coronary artery disease: a case–control study

Zhou, Yunping; Liu, Tongtao; Jia, Chongqi

doi:10.1136/bmjopen-2013-003695

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…A case-control study reported that serum ferritin and BMI had an additive interaction on the risk of CAD. 33 In the present study, raised ferritin levels were observed in overweight and obese individuals as classified by South Asian criteria of BMI.…”

Section: Resultssupporting

confidence: 50%

Relation between Serum Ferritin Level and the Risk of Acute Myocardial Infarction

Medisetty

Runwal

Phalgune³

2022

JAPI

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Background: An association between increased incidence of acute myocardial infarction (AMI) and elevated levels of stored iron concentration was recently reported. The data in India regarding association between AMI and levels of serum ferritin are lacking. Objectives: To study the association between serum ferritin level and risk of AMI. Materials and Methods: The present case-control study was conducted from May 2016 to October 2017 on 64 patients aged ≥30 years of either sex who were diagnosed with AMI (group I) and 60 controls (group II). Patients who attended outpatient department of hospital for minor illnesses, routine health checkups, and persons accompanying patients were selected randomly as controls. The controls had no signs of AMI or coronary heart disease (CHD) on clinical examination and had normal electrocardiogram (ECG). Quantitative measurement of serum ferritin was done in all subjects. The Chi-square or Fisher’s exact test and unpaired t-test were used to compare the categorical and quantitative variables, respectively. The independent association of serum ferritin with AMI was tested using multivariate logistic regression analysis. Results: The mean serum ferritin level was significantly higher in group I (203.5 µg/L) as compared to group II (111.8 µg/L). In group I, 82.9% patients had serum ferritin ≥150 µg/L as compared to group II (15.0%) with p-value = 0.001. Multivariate analysis showed history of smoking, body mass index (BMI) >25 kg/m2 , serum ferritin levels >200 µg/L, and high-density lipoprotein (HDL) cholesterol level <35mg/dL were independent and significant determinants of AMI. Conclusions: There was an association between elevated serum ferritin levels with AMI.

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Section: Resultssupporting

confidence: 50%

Relation between Serum Ferritin Level and the Risk of Acute Myocardial Infarction

Medisetty

Runwal

Phalgune³

2022

JAPI

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“…CAD patients with obesity are referred to cardiac rehabilitation and those who were enrolled in cardiac rehabilitation programme showed decreased weight and BMI (Sadeghiet et al 2013). However, while most earlier casecontrol studies showed significantly higher mean BMI (Kosuge et al 2006;Amani et al 2010;Singh et al 2013;Zhou et al 2013), Panwar et al (2011) could not find significant difference in BMI between patients and controls. There were also studies that showed higher prevalence of obesity in CAD patients than controls (Amani et al 2010;Singh et al 2013).…”

Section: Coronary Artery Diseasementioning

confidence: 82%

Analysis of Modal Choice of Residents in Lagos State

Olatoye¹

2019

JHE

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We investigated the role of Body mass index (BMI) in non-communicable diseases-polycystic ovary syndrome (PCOS), type 2 diabetes (T2DM) and coronary artery disease (CAD). Using a case control design, we compared mean BMI and its categories, in gender and disease specific samples, and computed odds ratios as well as receiver operator characteristic (ROC) curve. The 95 percentile cut off values were also determined but only for controls. We found mean BMI and prevalence of obesity to be higher in PCOS and T2DM and lower in CAD cases than controls. The ROC analysis suggested gender specific cut-off values are more sensitive than pooled sample. The area under the ROC curve which is highly significant suggests predictive utility of the BMI cut off values both for PCOS and T2DM.

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“…For example, serum ferritin levels and body mass index have an additive effect on the risk of coronary artery disease. 15 Cigarette smoking interacts synergistically with chronic infection of hepatitis C virus in men and with heavy alcohol consumption in women. 16 These reports suggest that smoking in women may interact with OC use in cervical carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Association of Combined Tobacco Smoking and Oral Contraceptive Use With Cervical Intraepithelial Neoplasia 2 or 3 in Korean Women

Kim

Seo

et al. 2016

Journal of Epidemiology

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BackgroundCigarette smoking and oral contraceptive (OC) use have been associated with cervical neoplasia, and the combination of smoking and OC use could influence cervical carcinogenesis. We aimed to assess the joint effect of smoking and OC use on the risk of cervical intraepithelial neoplasia (CIN).MethodsFrom a cohort of human papillomavirus-positive subjects recruited from 6 hospitals in Korea from March 2006 to November 2012, a total of 678 subjects (411 control, 133 CIN 1, and 134 CIN 2 or 3 cases) were selected for this study (mean age, 43 years). The risk of CIN associated with smoking and OC use on additive and multiplicative scales was estimated via multinomial logistic regression after adjustment for potential confounding factors. The relative excess risk due to interaction (RERI) and the synergy index (S) were used to evaluate the additive interaction.ResultsOC users (odds ratio [OR] 1.98; 95% confidence interval [CI], 1.07–3.69) and long-term OC use (≥20 months; OR 2.71; 95% CI, 1.11–6.59) had a higher risk of CIN 2/3, but had no association with CIN 1, compared to non-OC users. Smokers and heavy smoking (≥8 cigarettes/day) were not associated with any CIN grade. Combined smoking and OC use (OR 4.91; 95% CI, 1.68–14.4; RERI/S, 3.77/27.4; P for multiplicative interaction = 0.003) and combined heavy smoking and long-term OC use (OR 11.5; 95% CI, 1.88–70.4; RERI/S, 9.93/18.8; P for multiplicative interaction = 0.009) had a higher risk of CIN 2/3 but had no association with CIN 1 compared to combined non-smoking and non-OC use.ConclusionsOC use and smoking acted synergistically to increase the risk of CIN 2 or 3 in Korean women.

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Joint effects of serum ferritin and body mass index on the risk of coronary artery disease: a case–control study

Cited by 6 publications

References 29 publications

Relation between Serum Ferritin Level and the Risk of Acute Myocardial Infarction

Relation between Serum Ferritin Level and the Risk of Acute Myocardial Infarction

Analysis of Modal Choice of Residents in Lagos State

Association of Combined Tobacco Smoking and Oral Contraceptive Use With Cervical Intraepithelial Neoplasia 2 or 3 in Korean Women

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