Johne's disease in New Zealand: the past, present and a glimpse into the future

Lisle, G.W. de

doi:10.1080/00480169.2002.36268

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…Efforts are being made to use new molecular biology techniques to develop more accurate diagnostic tests and more effective vaccines (de Lisle 2002;Murray and Dupont 2002). What is now required to resolve the issue of the size of effects on production is a good diagnostic test for subclinical disease.…”

Section: Discussionmentioning

confidence: 99%

The effect of Johne's disease on production traits in Romney, Merino and Merino x Romney-cross ewes

Morris

Hickey

2006

New Zealand Veterinary Journal

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Productivity losses from clinical cases of Johne's disease would be of considerable economic importance in flocks with a high incidence of the disease. The lack of good diagnostic tests for Johne's disease in the live animal, and the lack of active surveillance programmes, has made it difficult to establish the true prevalence of Johne's disease in sheep flocks in New Zealand, and its economic consequences.

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Section: Discussionmentioning

confidence: 99%

The effect of Johne's disease on production traits in Romney, Merino and Merino x Romney-cross ewes

Morris

Hickey

2006

New Zealand Veterinary Journal

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“…In New Zealand, several of these vaccines have been used in cattle and sheep since the mid-1950s (Chandler 1957;Munday 1959;Hilbink and West 1990;de Lisle 2002), almost all of which have been based on whole or disrupted cells containing live or killed M. ptb with a variety of oil-based adjuvants; some contained fi nely ground pumice, which acted as an irritant to promote a strong host reaction. Generally, vaccines give signifi cant protection against clinical disease in sheep and cattle and, although they do not prevent infection, they appear to limit proliferation of M. ptb in the intestine and reduce faecal shedding (Emery and Whittington 2004).…”

Section: Introductionmentioning

confidence: 99%

Efficacy, immune responses and side-effects of vaccines against Johne's disease in young red deer (Cervus elaphus) experimentally challenged withMycobacterium aviumsubsp paratuberculosis

Mackintosh¹,

Labes²,

Thompson³

et al. 2008

New Zealand Veterinary Journal

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The experimental challenge with M. ptb produced subclinical Johne's disease in the majority of deer, but did not cause any clinical disease. The number and severity of gross and microscopic lesions was significantly reduced in the COM compared with Control and EXP groups; vaccination of the EXP group did not appear to give significant protection. Deer vaccinated with the commercial vaccine are likely to give a false-positive reaction to the MCT but should have an avian reaction to the CCT, if it is carried out >12 months after vaccination. Most of the deer vaccinated with the commercial vaccine produced significant levels of antibodies against both M. ptb and M. bovis, which interfered with ancillary Tb tests. If this vaccine or similar oil-based vaccines are used on deer farms in the future, it may be advisable to only vaccinate animals destined for slaughter, that would not need to be Tb-tested, but would be 'works-monitored' for evidence of Tb instead.

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“…While it has been suggested previously that deer might be equally susceptible to both bovine and ovine strains of M. avium subsp. paratuberculosis (6,8,9), there have been few independent verifications of this, and reviews commonly cite an instance from 1993 in which three cervine-derived isolates exhibited IS900 RFLP banding patterns similar to those generated by ovine-strain isolates in New Zealand (9). Whittington et al summarized some documented occurrences in ruminants of strains of M. avium subsp.…”

Section: Vol 74 2006 Immune Response To Johne's Disease In Deer 3533mentioning

confidence: 99%

Immunological and Molecular Characterization of Susceptibility in Relationship to Bacterial Strain Differences inMycobacterium aviumsubsp.paratuberculosisInfection in the Red Deer (Cervus elaphus)

O’Brien

Mackintosh²,

Bakker³

et al. 2006

Infect Immun

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Johne's disease (JD) infection, caused by Mycobacterium avium subsp. paratuberculosis, represents a major disease problem in farmed ruminants. Although JD has been well characterized in cattle and sheep, little is known of the infection dynamics or immunological response in deer. In this study, typing of M. avium subsp. paratuberculosis isolates from intestinal lymphatic tissues from 74 JD-infected animals showed that clinical isolates of M. avium subsp. paratuberculosis from New Zealand farmed red deer were exclusively of the bovine strain genotype. The susceptibility of deer to M. avium subsp. paratuberculosis was further investigated by experimental oral-route infection studies using defined isolates of virulent bovine and ovine M. avium subsp. paratuberculosis strains. Oral inoculation with high (10 9 CFU/animal) or medium (10 7 CFU/animal) doses of the bovine strain of M. avium subsp. paratuberculosis established 100% infection rates, compared to 69% infection following inoculation with a medium dose of the ovine strain. The high susceptibility of deer to the bovine strain of M. avium subsp. paratuberculosis was confirmed by a 50% infection rate following experimental inoculation with a low dose of bacteria (10 3 CFU/animal). This study is the first to report experimental M. avium subsp. paratuberculosis infection in red deer, and it outlines the strong infectivity of bovine-strain M. avium subsp. paratuberculosis isolates for cervines.

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Johne's disease in New Zealand: the past, present and a glimpse into the future

Cited by 12 publications

References 23 publications

The effect of Johne's disease on production traits in Romney, Merino and Merino x Romney-cross ewes

The effect of Johne's disease on production traits in Romney, Merino and Merino x Romney-cross ewes

Efficacy, immune responses and side-effects of vaccines against Johne's disease in young red deer (Cervus elaphus) experimentally challenged withMycobacterium aviumsubsp paratuberculosis

Immunological and Molecular Characterization of Susceptibility in Relationship to Bacterial Strain Differences inMycobacterium aviumsubsp.paratuberculosisInfection in the Red Deer (Cervus elaphus)

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