Johanniskraut als pflanzliches Antidepressivum

Schulz, Volker

doi:10.1007/978-3-642-85434-7_14

Cited by 2 publications

(1 citation statement)

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“…In addition, this herb has been traditionally used as a health enhancer, as a wound healer (Suntar et al, 2010), as well as for antibacterial (Schulz, 1995;Saddiqe et al, 2010) anti-viral (Hudson et al, 1991;Pang et al, 2010) and anti-retroviral (Lavie et al, 1989;Chinsembu & Hedimbi, 2010) activities; finally, a strong antitumor effect has been recently reported (Schempp et al, 2002;Beerhues, 2006;Medina et al, 2006). Phytochemical characterization reports hyperforin (a prenylated phloroglucinol) and hypericin (a naphthodianthrone), as the main chemicals responsible for effects on health, although other biologically active constituents, e.g., flavonoids, tannins, are also present (Barnes et al, 2001).…”

Section: Research Articlementioning

confidence: 99%

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Mañero

Algar

Gómez

et al. 2012

Pharmaceutical Biology

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Section: Research Articlementioning

confidence: 99%

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Mañero

Algar

Gómez

et al. 2012

Pharmaceutical Biology

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St. John’s Wort – an Overview

Linde¹

2009

Forsch Komplementmed

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This article aims to summarize the current state of knowledge on St. John’s wort (Hypericum perforatum L.) which is one of the oldest and best investigated medicinal herbs. Dried alcoholic extracts are the most important preparations on the market although a variety of other preparations are available. Depressive disorders according to modern diagnostic standards are the best known and most widely investigated indication although the more traditional, broader indication of ‘psycho-vegetative disorders, depressive disorders, anxiety and/or nervous agitation’, including diagnoses such as somatoform disorders, might more adequately describe what Hypericum extracts are actually used for by many practitioners. The exact mechanisms of action are still unclear, but the available research clearly shows that various bioactive constituents contribute to the clinical effects reported, often in a synergistic manner. Hypericum extracts have consistently shown activity in pharmacological models related to antidepressant effects. Randomized clinical trials show that Hypericum extracts are more effective than placebo and similarly effective as standard antidepressants while having better tolerability in the acute treatment of major depressive episodes. The most important risk associated with Hypericum extracts are interactions with other drugs. Therefore, physicians need to be informed whether their patients take St. John’s wort products. If the risk of interactions is adequately taken into account, high quality Hypericum extracts are an effective and safe tool in the hand of qualified health profession-als in primary care.

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Johanniskraut als pflanzliches Antidepressivum

Cited by 2 publications

References 4 publications

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

St. John’s Wort – an Overview

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Johanniskraut als pflanzliches Antidepressivum

Cited by 2 publications

References 4 publications

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

St. John&rsquo;s Wort &ndash; an Overview

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Product

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St. John’s Wort – an Overview