Elicitation of secondary metabolism in<i>Hypericum perforatum</i>by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Mañero, F. J. Gutiérrez; Algar, Elena; Gómez, María Soledad Martín; Sierra, M. Dolores Saco; Ramos‐Solano, Beatriz

doi:10.3109/13880209.2012.664150

Cited by 55 publications

(18 citation statements)

References 70 publications

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“…However, root culture challenged by Agrobacterium tumefaciens did not show any significant increase in glycyrrhizic acid content [135]. The gradual increase in hypericin and pseudohypericin was observed in seedlings of H. perforatum after challenging with Rhizobacterium [139]. Coronatine, phytotoxin produced by the Pseudomonas syringae species significantly induced taxane synthesis in taxane media cell cultures [140], also induced the viniferins production in the cell culture of V. vinifera [91].…”

Section: Bacterial Originmentioning

confidence: 99%

Abiotic and Biotic Elicitors–Role in Secondary Metabolites Production through In Vitro Culture of Medicinal Plants

Naik¹,

Al–Khayri²

2016

Abiotic and Biotic Stress in Plants - Recent Advances and Future Perspectives

123

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Plant secondary metabolites are having the great application in human health and nutritional aspect. Plant cell and organ culture systems are feasible option for the production of secondary metabolites that are of commercial importance in pharmaceuticals, food additives, flavors, and other industrial materials. The stress, including various elicitors or signal molecules, often induces the secondary metabolite production in the plant tissue culture system. The recent developments in elicitation of plant tissue culture have opened a new avenue for the production of secondary metabolite compounds. Secondary metabolite synthesis and accumulation in cell and organ cultures can be triggered by the application of elicitors to the culture medium. Elicitors are the chemical compounds from abiotic and biotic sources that can stimulate stress responses in plants, leading to the enhanced synthesis and accumulation of secondary metabolites or the induction of novel secondary metabolites. Elicitor type, dose, and treatment schedule are major factors determining the effects on the secondary metabolite production. The number of parameters, such as elicitor concentrations, duration of exposure, cell line, nutrient composition, and age or stage of the culture, is also important factors influencing the successful production of biomass and secondary metabolite accumulation. This chapter reviews the various abiotic and biotic elicitors applied to cultural system and their stimulating effects on the accumulation of secondary metabolites.

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Section: Bacterial Originmentioning

confidence: 99%

Abiotic and Biotic Elicitors–Role in Secondary Metabolites Production through In Vitro Culture of Medicinal Plants

Naik¹,

Al–Khayri²

2016

Abiotic and Biotic Stress in Plants - Recent Advances and Future Perspectives

123

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“…Elicitation of isoflavone accumulation was observed on soybean inoculated with various PGPR, either by increasing the total isoflavone content in seedlings or by causing an asymmetric distribution of isoflavones throughout the plant (Ramos-Solano et al, 2010). Increase in the content of several alkaloid and terpenoid compounds of pharmaceutical relevance was demonstrated in medicinal plants following PGPR inoculation (Manero et al, 2003; Jaleel et al, 2007; Bharti et al, 2013). Recent studies investigated the early impact of several Azospirillum strains on root and shoot secondary metabolite profiles of maize and rice; analysis of secondary metabolites of two maize cultivars, inoculated by three different Azospirillum strains under greenhouse conditions, revealed major qualitative and quantitative modifications of the contents of secondary metabolites, especially benzoxazinoids (Walker et al, 2011).…”

Section: Systemic Effects Of Pgpr On Whole Plant Physiology and Functmentioning

confidence: 99%

Plant growth-promoting rhizobacteria and root system functioning

Vacheron¹,

Desbrosses²,

Bouffaud³

et al. 2013

Front. Plant Sci.

1,123

647

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The rhizosphere supports the development and activity of a huge and diversified microbial community, including microorganisms capable to promote plant growth. Among the latter, plant growth-promoting rhizobacteria (PGPR) colonize roots of monocots and dicots, and enhance plant growth by direct and indirect mechanisms. Modification of root system architecture by PGPR implicates the production of phytohormones and other signals that lead, mostly, to enhanced lateral root branching and development of root hairs. PGPR also modify root functioning, improve plant nutrition and influence the physiology of the whole plant. Recent results provided first clues as to how PGPR signals could trigger these plant responses. Whether local and/or systemic, the plant molecular pathways involved remain often unknown. From an ecological point of view, it emerged that PGPR form coherent functional groups, whose rhizosphere ecology is influenced by a myriad of abiotic and biotic factors in natural and agricultural soils, and these factors can in turn modulate PGPR effects on roots. In this paper, we address novel knowledge and gaps on PGPR modes of action and signals, and highlight recent progress on the links between plant morphological and physiological effects induced by PGPR. We also show the importance of taking into account the size, diversity, and gene expression patterns of PGPR assemblages in the rhizosphere to better understand their impact on plant growth and functioning. Integrating mechanistic and ecological knowledge on PGPR populations in soil will be a prerequisite to develop novel management strategies for sustainable agriculture.

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“…Treatment of H. perforatum seedlings with Stenotrophomonas maltophilia increased the hypericin and pseudohypericin contents . These authors also reported that treating H. perforatum shoot cultures with a S. maltophilia culture filtrate induced only pseudohypericin production …”

Section: Manipulation Of Hypericum Perforatum Secondary Metabolism VImentioning

confidence: 82%

“…Elicitation of H. perforatum shoot cultures with a combination of saccharose and inactivated Agrobacterium tumefaciens promoted the hypericin and hyperforin production . Treatment of H. perforatum seedlings with Stenotrophomonas maltophilia increased the hypericin and pseudohypericin contents . These authors also reported that treating H. perforatum shoot cultures with a S. maltophilia culture filtrate induced only pseudohypericin production …”

Section: Manipulation Of Hypericum Perforatum Secondary Metabolism VImentioning

confidence: 88%

“…[69] Treatment of H. perforatum seedlings with Stenotrophomonas maltophilia increased the hypericin and pseudohypericin contents. [70] These authors also reported that treating H. perforatum shoot cultures with a S. maltophilia culture filtrate induced only pseudohypericin production. [70] Analysis of the methanolic extract of cell suspension cultures treated with A. tumefaciens revealed a 12-fold increase in the total xanthone concentration and the emergence of [41] Iron nano-oxide Hypericin and hyperforin [41] Chitin Phenolics, flavonols, flavanols, anthocyanins, hypericin and pseudohypericin [66] Pectin Phenolics, flavonols, flavanols, anthocyanins, hypericin and pseudohypericin [66] Dextran Phenolics, flavonols, flavanols, anthocyanins, hypericin and pseudohypericin [66] Phytophthora cinnamoni fungal cell wall extract None [39] Colletotrichum gloeosporioides mycelium extract Xanthones and flavonoids [35] Aspergillus flavus mycelium extract Phenolic compounds, flavanols, flavonols, anthocyanins and hypericins [62] Fusarium oxysporum Phenolics, flavonoids, anthocyanins, hypericin and pseudohypericin [63] Phoma exigua Phenolics, flavonoids, anthocyanins, hypericin and pseudohypericin [63] Botrytis cinerea Phenolics, flavonoids, anthocyanins, hypericin and pseudohypericin [63] JA Hypericins [39] JA Phenolic compounds, flavanols, flavonols, hypericin and pseudohypericin [38] MeJA Flavones [35] MeJA Flavonoids [8] SA Xanthones [85] SA None [35] SA None [39] SA Hypericins, pseudohypericins [86] SA Flavonoids [8] MeJA + C. gloeosporioides Xanthones [35] SA + C. gloeosporioides Xanthones [35] Agrobacterium tumefaciens Xanthones [71] A. tumefaciens Lignin and flavanoids [72] A. tumefaciens Phenolics, flavonols, flavanols and xanthones [73] A. rhizogenes Phenolics, flavonols, flavanols and xanthones [73] Callus SA Hypericins, pseudohypericins [86] Root MeJA Hypericin…”

Section: Fungi and Extracts From Fungal Myceliamentioning

confidence: 95%

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Elicitation as a tool to improve the profiles of high-value secondary metabolites and pharmacological properties of Hypericum perforatum

Shakya

Marslin

Karthik

et al. 2017

Journal of Pharmacy and Pharmacology

121

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Objectives In this review, we aim at updating the available information on the improvement of the Hypericum perforatum L. (Hypericaceae) phytochemical profile and pharmacological properties via elicitation. Key findings Hypericum perforatum seedlings, shoots, roots, calli and cell suspension cultures were treated with diverse elicitors to induce the formation of secondary metabolites. The extracts of the elicitor-treated plant material containing naphthodianthrones, phloroglucinols, xanthones, flavonoids and other new compounds were quantitatively analysed and tested for their bioactivities. While hypericins were mainly produced in H. perforatum cultures containing dark nodules, namely shoots and seedlings, other classes of compounds such as xanthones, phloroglucinols and flavonoids were formed in all types of cultures. The extracts obtained from elicitor-treated samples generally possessed better bioactivities compared to the extract of control biomass. Summary Although elicitation is an excellent tool for the production of valuable secondary metabolites in H. perforatum cell and tissue cultures, its exploitation is still in its infancy mainly due to the lack of reproducibility and difficulties in scaling up biomass production.

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Elicitation of secondary metabolism inHypericum perforatumby rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

Cited by 55 publications

References 70 publications

Abiotic and Biotic Elicitors–Role in Secondary Metabolites Production through In Vitro Culture of Medicinal Plants

Abiotic and Biotic Elicitors–Role in Secondary Metabolites Production through In Vitro Culture of Medicinal Plants

Plant growth-promoting rhizobacteria and root system functioning

Elicitation as a tool to improve the profiles of high-value secondary metabolites and pharmacological properties of Hypericum perforatum

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