Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway

Umukoro, Solomon; Oghwere, Ejiroghene E.; Ben‐Azu, Benneth; Owoeye, Olatunde; Ajayi, Abayomi Mayowa; Omorogbe, Osarume; Okubena, Olajuwon

doi:10.1016/j.pathophys.2018.10.002

Cited by 14 publications

(20 citation statements)

References 54 publications

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“…Neurological abilities of rats were measured on days 2, 5, 7, and 13 (Fig. 1) by utilizing a standard 12point modi ed neurological scale (NSS) (Liu et al, 2021;Umukoro et al, 2019). This scale is based on abnormal gait and hemiplegia.…”

Section: Behavioral Analysismentioning

confidence: 99%

Neuroprotective Effects of Theobromine in Permanent Bilateral Common Carotid Artery Occlusion Rat Model of Cerebral Hypoperfusion

Bhat

Kumar

2022

Preprint

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Cerebral hypoperfusion (CH) is a common underlying mechanism of dementia disorders linked to aberrations in the neurovascular unit. Hemodynamic disturbances adversely affect cellular energy homeostasis that triggers a sequence of events leading to irrevocable damage to the brain and neurobehavioral discrepancies. Theobromine is a common ingredient of many natural foods consumed by a large population worldwide. Theobromine has shown health benefits in several studies, attributed to regulation of calcium homeostasis, phosphodiesterase, neurotransmission, and neurotrophins. The current study evaluated the neuroprotective potential of theobromine against CH in the permanent bilateral common carotid artery occlusion (BCCAO) prototype. Wistar rats were distributed in Sham-operated (S), S+T100, CH, CH+T50, and CH+T100 groups. Animals received permanent BCCAO or Sham treatment on day 1. Theobromine (50, 100 mg/kg) was given orally in animals subjected to BCCAO for 14 days daily. CH caused neurological deficits (12-point scale), motor dysfunction, and memory impairment in rats. Treatment with theobromine significantly attenuated neurological deficits and improved sensorimotor functions and memory in rats with CH. In biochemistry investigation of the entire brain, findings disclosed reduction in brain oxidative stress, inflammatory intermediaries (tumor necrosis factor-α, interleukin-1β and -6, nuclear factor-κB), markers of cell demise (lactate dehydrogenase, caspase-3), acetylcholinesterase activity, and improvement in γ-aminobutyric acid quantity in rats that were given theobromine for 14 days daily after CH. Histopathological analysis substantiated attenuation of neurodegenerative changes by theobromine. The findings of this study indicated that theobromine could improve neurological scores, sensorimotor abilities, and memory in CH prototype.

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Section: Behavioral Analysismentioning

confidence: 99%

Neuroprotective Effects of Theobromine in Permanent Bilateral Common Carotid Artery Occlusion Rat Model of Cerebral Hypoperfusion

Bhat

Kumar

2022

Preprint

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“…It has also has gained local and international recognition for the treatment of moderate to severe anaemia (as in sickle cell patients), as well as cancer and HIV/AIDS [19,24]. It is also widely used to combat stress and to restore the much-needed energy during periods of recovery from debilitating diseases [16]. There have been reports that…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…SBSJ is helpful in arthritis, cancer, and neurological disorders such as stroke, psychosis, and convulsions [16].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…In addition, it is known to modulate the immune system, enhancing the body's defence mechanisms in response to stress and infections, and to aid recovery from debilitating illnesses [16,17].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…Moreover, epidemiological data in the extant literature have evidenced that regular consumption of food rich in polyphenols can reduce the risk of stroke [78][79]. SBSJ has been experimentally evaluated against ischemic stroke induced through the occlusion of the bilateral common carotid artery by a group of scientists at the University of Ibadan [16]. The results of their investigations revealed that the neurological deficits produced by the occlusion of the bilateral common carotid artery in rats-which approximates the clinical characteristics seen in patients with ischemic stroke [80]-were attenuated by SBSJ [16].…”

Section: Sbsj As a Potential Remedy For Stroke Disordersmentioning

confidence: 99%

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Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

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Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

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Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status

et al. 2022

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Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway

Cited by 14 publications

References 54 publications

Neuroprotective Effects of Theobromine in Permanent Bilateral Common Carotid Artery Occlusion Rat Model of Cerebral Hypoperfusion

Neuroprotective Effects of Theobromine in Permanent Bilateral Common Carotid Artery Occlusion Rat Model of Cerebral Hypoperfusion

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status

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