Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status

John, R. F.; Abolaji, Amos O.; Adedara, Adeola Oluwatosin; Ajayi, Abayomi Mayowa; Aderibigbe, Adegbuyi Oladele; Umukoro, Solomon

doi:10.1007/s11011-022-00919-4

Cited by 3 publications

(3 citation statements)

References 50 publications

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“…In an in vitro stress model, it has also been reported that SBSJ protected RBCs against hyposaline-induced haemolysis [43], suggesting cyto-protection and increased cellular resistance to stress. Notably, the recent finding that SBSJ increased the survival rate and prolonged the lifespan of LPS-exposed Drosophila melanogaster reinforces its potential adaptogenic-like properties [93]. This is in agreement with previous reports linking adaptogens to increased lifespan and stress resistance in C. elegans [122]; another model organism widely used for elucidation of the neurobiological mechanisms of stress and age-related disorders.…”

Section: Sbsj As An Adaptogensupporting

confidence: 90%

“…A more recent study using Drosophila melanogaster showed that SBSJ extended the lifespan and improved motor function of the flies (Fig. 4), through augmentation of the antioxidant status [93]. In addition, it also extended the lifespan of Drosophila melanogaster exposed to lipopolysaccharide (LPS) [92].…”

Section: Strategic Focus On Interventions That Increase Lifespan In M...mentioning

confidence: 99%

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Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

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Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

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Section: Sbsj As An Adaptogensupporting

confidence: 90%

Section: Strategic Focus On Interventions That Increase Lifespan In M...mentioning

confidence: 99%

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies have shown that its polyphenolic constituents such as apigenin and luteolin exhibit anti-aging activity through neuroprotective mechanisms relating to anti-inflammatory, antioxidant, and anti-apoptosis effects 78,82,90 . Interestingly, the first concrete evidence regarding its anti-aging effect came from a study conducted at Brunswick Laboratory, USA, which revealed that it inhibited the activity of elastase-1 and collagenase-1 15 : enzymes that have been implicated in premature aging, especially, the aging of the skin 91 . Specifically, SBJS was shown to be more effective than vitamin C and ferulic acid in inhibiting collagenase and elastase, suggesting its capability to promote skin health 15 .…”

Section: Anti-aging Potential Of Sbjsmentioning

confidence: 99%

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

Adebesin,

Omogbiya,

Oluwole

et al. 2024

JNR

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Globally, across different cultures, humans have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants have been strongly attributed to the presence of secondary metabolites, particularly polyphenols. The potential health benefits of the leaf sheaths of the West African variety of Sorghum bicolor-based Jobelyn Supplement (SBJS) have also been ascribed to its high contents of polyphenols. This systematic review seeks to synthetically harmonize findings from various experimental and clinical studies on the health benefits of SBJS in different disease conditions including arthritis, cancer, chronic viral infections, stroke, anaemia, and premature aging. A systematic search was conducted using three primary databases (PubMed, Europe PMC, and Cochrane Library), to identify published articles on therapeutic potentials of SBJS and ethnomedicinal surveys on the application of the West African variety of S. bicolor using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standard. The inclusion criteria were experimental and clinical studies conducted on SBJS and West African variety of S. bicolor; while ethnomedicinal surveys were on the therapeutic uses of the West African variety of S. bicolor published in the English language. The review provides valuable information suggesting that SBJS possesses pleiotropic therapeutic potentials in diverse pathological conditions through mechanisms relating to antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. The review also showed that SBJS contains several bioactive substances with polyvalent pharmacological potentials including modulation of pathological mechanisms involved in the mediation of aging and age-related diseases, such as arthritis, stroke, memory loss and cancer as well as chronic viral infections. Taken together, these findings further suggest the need for more robust studies (including disease-specific clinical trial programs) in order to replicate and validate the prior insights gleaned from previous investigations on SBJS.

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Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase

Umukoro,

Ajayi,

Ben-Azu

et al. 2023

Metab Brain Dis

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Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status

Cited by 3 publications

References 50 publications

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase

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