Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen

Alfredsson, Lars; Hammar, Niklas; Fransson, Eleanor; Fairé, Ulf dé; Hallqvist, Johan; Knutsson, Anders; Nilsson, Tohr; Theorell, T; Westerholm, Peter

doi:10.5271/sjweh.671

Cited by 92 publications

(102 citation statements)

References 45 publications

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“…The data were obtained from the WOLF (Work, Lipids, and Fibrinogen) occupational cohort study that included subjects who were employed in different public and private companies (35). The baseline study was first carried out in Stockholm, Sweden, from 1992-1995 (WOLFS, N=5698).…”

Section: Methodsmentioning

confidence: 99%

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Knutsson¹,

Alfredsson²,

Karlsson³

et al. 2012

Scand J Work Environ Health

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101

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This cohort study showed that shift work with night shifts is associated with increased risk of breast cancer, but not shift work without night shifts. Research on the disease mechanisms needs to be intensified. Original article Scand J Work Environ Health. 2013;39(2):170-177. doi:10.5271/sjweh.3323 Breast cancer among shift workers: results of the WOLF longitudinal cohort study Objective The aim of this study was to investigate whether shift work (with or without night work) is associated with increased risk of breast cancer. Affiliation MethodsThe population consisted of 4036 women. Data were obtained from WOLF (Work, Lipids, and Fibrinogen), a longitudinal cohort study. Information about baseline characteristics was based on questionnaire responses and medical examination. Cancer incidence from baseline to follow-up was obtained from the national cancer registry. Two exposure groups were identified: shift work with and without night work. The group with day work only was used as the reference group in the analysis. Cox regression analysis was used to calculate relative risk. ResultsIn total, 94 women developed breast cancer during follow-up. The average follow-up time was 12.4 years. The hazard ratio for breast cancer was 1.23 [95% confidence interval (95% CI) 0.70-2.17] for shifts without night work and 2.02 (95% CI 1.03-3.95) for shifts with night work. When including only women <60 years of age, the risk estimates were 1.18 (95% CI 0.67-2.07) for shifts without night work, and 2.15 (95% CI 1.10-4.21) for shifts with night work. ConclusionsOur results indicate an increased risk for breast cancer among women who work shifts that includes night work.

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Section: Methodsmentioning

confidence: 99%

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Knutsson¹,

Alfredsson²,

Karlsson³

et al. 2012

Scand J Work Environ Health

Self Cite

101

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“…Adjusting for mediating factors may result in controlling for a part of the effect under study, which contributes to an underestimation of the overall effect of psychosocial work factors on BP (210). To avoid such a limitation, five studies (23,124,157,186,187) evaluated the additional effect of adjusting for lifestyle, cardiovascular risk factors in a supplementary statistical model (ie, sequential adjustment). In all of these studies, this additional adjustment only resulted in a slight change in the effect measures presented.…”

Section: (Tables A-c)mentioning

confidence: 99%

Adverse effects of psychosocial work factors on blood pressure: systematic review of studies on demand–control–support and effort–reward imbalance models

Gilbert-Ouimet¹,

Trudel²,

Brisson³

et al. 2013

Scand J Work Environ Health

180

136

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This is the first systematic review and critical synthesis on the adverse effects of psychosocial work factors of the demand-control-support and effort-reward imbalance models on blood pressure. A more consistent effect has been observed among men than women and among studies of higher methodological quality. Evidence-based guidelines for cardiovascular diseases prevention may benefit from these findings.Affiliation: Population health research unit, St-Sacrement hospital,

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“…We used pooled individual-level data from 7 European prospective cohort studies participating in the Individual-participant-data Meta-analysis in Working Populations (IPD-Work) Consortium: 7 the Whitehall II Study in the United Kingdom; 12 the GAZEL Study in France; 13 the Belgian Job Stress Project (Belstress); 14 the Work, Lipids, and Fibrinogen Study in Stockholm (WOLF-S) 15 and in Norrland (WOLF-N), 16 Sweden; the Finnish Public Sector Study; 17 and the Health and Social Support (HeSSup) Study in Finland. 18 Details of the study design and participants have been published previously and are summarized in Appendix 1 (available at www.cmaj.ca/lookup /suppl/doi:10.1503/cmaj.121735/-/DC1).…”

Section: Study Populationmentioning

confidence: 99%

Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data

Kivimäki

Nyberg

Fransson³

et al. 2013

CMAJ

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101

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Background: It is unclear whether a healthy lifestyle mitigates the adverse effects of job strain on coronary artery disease. We examined the associations of job strain and lifestyle risk factors with the risk of coronary artery disease. Methods: We pooled individual-level data from 7 cohort studies comprising 102 128 men and women who were free of existing coronary artery disease at baseline (1985-2000). Questionnaires were used to measure job strain (yes v. no) and 4 lifestyle risk factors: current smoking, physical inactivity, heavy drinking and obesity. We grouped participants into 3 lifestyle categories: healthy (no lifestyle risk factors), moderately unhealthy (1 risk factor) and unhealthy (2-4 risk factors). The primary outcome was incident coronary artery disease (defined as first nonfatal myocardial infarction or cardiac-related death). Results: There were 1086 incident events in 743 948 person-years at risk during a mean follow-up of 7.3 years. The risk of coronary artery disease among people who had an unhealthy lifestyle compared with those who had a healthy lifestyle (hazard ratio [HR] 2.55, 95% confidence interval [CI] 2.18-2.98; population attributable risk 26.4%) was higher than the risk among participants who had job strain compared with those who had no job strain (HR 1.25, 95% CI 1.06-1.47; population attributable risk 3.8%). The 10-year incidence of coronary artery disease among participants with job strain and a healthy lifestyle (14.7 per 1000) was 53% lower than the incidence among those with job strain and an unhealthy lifestyle (31.2 per 1000). Interpretation: The risk of coronary artery disease was highest among participants who reported job strain and an unhealthy lifestyle; those with job strain and a healthy lifestyle had half the rate of disease. A healthy life style may substantially reduce disease risk among people with job strain

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Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen

Cited by 92 publications

References 45 publications

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Breast cancer among shift workers: results of the WOLF longitudinal cohort study

Adverse effects of psychosocial work factors on blood pressure: systematic review of studies on demand–control–support and effort–reward imbalance models

Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data

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