Job's Method of Continuous Variations with Ion Exchange for the Study of Complexes in Solution

Abstract

16.0 = 10.0 cal./(mole °K.). This is well within experimental error of the 10.1 cal./(mole °K.) calcu-lated by Westrum and Payne and, as such, is further evidence for the proper choice of mechanism for the observed transitions.Acknowledgment. This work was performed under the auspices of the United States Atomic Energy Commission. The authors are indebted to Dr. Elfreda Chang for assistance in the evaluation of the data.

Synthesis and Biological Evaluation of Naphthyldesferrithiocin Iron Chelators

“…The nature of the iron(III) complexes of the naphthyl DFTs 4 and 6 in solution was studied by Job's method , of continuous variation of isomolar ligand and iron(III) solutions. Job's plots of 4 and 6 revealed that both of the DFT analogues form a 2:1 complex with iron(III) at pH 7.2, as is expected for a tridentate ligand.…”

“…The starting material for the synthesis of the naphthyl DFTs 6 and 7 was 3-hydroxy-2-naphthoic acid (15) (Scheme 2). The hydroxyl group was acylated with The nature of the iron(III) complexes of the naphthyl DFTs 4 and 6 in solution was studied by Job's method 44,45 of continuous variation of isomolar ligand and iron(III) solutions. Job's plots of 4 and 6 revealed that both of the DFT analogues form a 2:1 complex with iron(III) at pH 7.2, as is expected for a tridentate ligand.…”