volume 26, issue 2, P315-329 2011
DOI: 10.3233/jad-2011-110320
View full text
|
Sign up to set email alerts
|
Share

Abstract: Alzheimer's disease (AD) is a major clinical concern, and the search for new molecules to combat disease progression remains important. One of the major hallmarks in AD pathogenesis is the hyperphosphorylation of tau and subsequent formation of neurofibrillary tangles. Several kinases are involved in this process. Amongst them, c-Jun N-terminal kinases (JNKs) are activated in AD brains and are also associated with the development of amyloid plaques. This study was designed to investigate the contribution of JN…

Expand abstract