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Abstract

The study suggests that micro-TA may be used to assess interparticulate composition and homogeneity.

Physical and thermal characterisation of chiral omeprazole sodium salts

“…Amongst the different techniques, atomic force microscopy (AFM), as derived from scanning probe microscopy by Binning et al [10], can be combined with thermal capabilities for surface analysis, as reviewed by Giron [11]. Many pharmaceutical systems/drugs as well as excipients have been investigated over the past 10 years using microthermal analysis (TA): indomethacin [12,13], ibuprofen [14], pyridoxal hydrochloride [15], paracetamol [16], progesterone [17], cimetidine [18], etc. TA is often complimentary to bulk measurement techniques such as microcalorimetry [19] or DSC [15].…”