Jellyfish‐Based Smart Wound Dressing Devices Containing In Situ Synthesized Antibacterial Nanoparticles

Abstract

Although the negative consequences of the global phenomenon of jellyfish (JF) swarms are well recognized, the use of their biomass for practical applications is mostly limited to a niche in the Asian food industry. This fact is quite surprising since JF's biomass comprises useful biomaterials such as Q‐mucin glycoprotein and collagen. In this work, the JF biomass, collected from two different species, is used to prepare electrospun scaffolds composed of nanometric “core–shell”‐type fibers, in which adjustment of the electrospinning process parameters can easily control their mechanical, morphological, and chemical properties. This nonwoven scaffold shows excellent biocompatibility and biodegradability, indicating suitability for biomedical research contexts. Performed cell proliferation assays show that the scaffold could support the growth of cardiac cells, fitting the requirement of tissue engineering. Additional incorporation of in situ‐generated silver nanoparticles in these nanofibers produced mats with potent antibacterial properties. Preclinical trials with the resulted mats on porcine wound healing models exhibit fast and complete healing of wounds.

Biotechnological Applications of Scyphomedusae

“…In addition to collagen, Nudelman et al [154] used Q-mucin glycoproteins from Rhopilema nomadica Galil 1990 and Nemopilema nomurai made of nanometric fibers to produce scaffolds. The nanometric fibers allowed them to control the mechanical, morphological and chemical properties of the scaffolds, which showed a very high degree of biocompatibility and biodegradability.…”

The Essentials of Marine Biotechnology

“…Jellyfish extracted molecules (proteins, peptides, mucins) have antioxidant, wound healing and antimicrobial properties (Merquiol et al, 2019;Nudelman et al, 2019). The most famous jellyfish-derived compound is the green fluorescent protein (GFP), one of the most important tools in molecular biology research, serving as a molecular marker alongside other that found important applications in wider scientific research, and was awarded the Nobel Prize in Chemistry in 2008 to Osamu Shimomura, Martin Chalfie, and Roger Tsien.…”

Electrospun Nanofibrous Materials for Wound Healing

“…In addition, the relatively large surface area of the nanofibrous mats is conducive to drug/biomolecules loading and delivery [22]. Electrospinning offers an efficient way for producing well-organized nanofibrous scaffolds in biomedical fields, including tissue engineering [23], drug delivery [24] and wound dressing [25,26] owing to high Yuping Dong and Yuqi Zheng contributed equally to the work. versatility in material choice, ease of control over patterning and great flexibility in drug formulation [27,28].…”