Jejunal Glucose Absorption Is Enhanced by Epidermal Growth Factor in Mice

Bird, Anthony R.; Croom, W. J.; Yang, Fan; Daniel, Linda R.; Black, Betty L.; McBride, B.W.; Eisen, E. J.; Bull, Leonard S.; Taylor, Ian L.

doi:10.1093/jn/124.2.231

Cited by 35 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have investigated the effects of EGF on intestinal growth and development (Malo and Ménard, 1982) and function (Bird et al, 1994) using rodent models (Koldovsky et al, 1992 for review). Fewer studies have been performed on species of agricultural importance.…”

Section: Concentrations Inmentioning

confidence: 99%

Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Odle

Zijlstra

Donovan

1996

Journal of Animal Science

138

View full text Add to dashboard Cite

Reduction of postnatal morbidity and mortality of mammalian neonates poses a significant challenge to agricultural and medical sciences. Because nutritional insufficiency and diarrhea represent major stressors, an understanding of factors mediating postnatal growth and development of the gastrointestinal tract is essential. This review explores the role that milkborne growth factors may play in stimulating functional development of the neonatal intestine, with emphasis on the porcine, bovine, and ovine species. Studies reporting milk concentrations and intestinal effects are reviewed, with emphasis on epidermal growth factor, insulin, and the insulin-like growth factors. Collectively, these studies suggest that milkborne growth factors may provide important regulatory signals to the neonatal intestine under both normal and pathophysiological states.

show abstract

Section: Concentrations Inmentioning

confidence: 99%

Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Odle

Zijlstra

Donovan

1996

Journal of Animal Science

138

View full text Add to dashboard Cite

show abstract

“…Second, the F line turkeys selected for rapid growth, are not phenotypically expressing their full genetic potential because of suboptimal intestinal absorptive capacity or energetic efficiency. Administration of an exogenous enhancer of intestinal absorption or energetic efficiency, such as epidermal growth factor (Bird et al 1994b) or peptide YY (Bird et al 1996b), may allow resolution of this question. Should future research confirm the hypothesis that suboptimal efficiency of intestinal nutrient absorption is rate-limiting for performance in turkeys, strategies can be devised to correct this problem and enhance production.…”

Section: Discussionmentioning

confidence: 99%

“…The apparent energetic efficiency of glucose uptake was calculated as described by Bird et al (1994b) and Fan et al (1996a,b). Jejunal respiration and glucose uptake estimates were conducted concurrently on adjacent pieces of tissue.…”

Section: Calculation Of the Apparent Energetic Efficiency Of Glucose mentioning

confidence: 99%

Apparent energetic efficiency of jejunal glucose uptake in young adult turkeys selected for rapid growth

Yang¹,

Croom²,

Christensen³

et al. 1998

Can. J. Anim. Sci.

View full text Add to dashboard Cite

. 1998. Apparent energetic efficiency of jejunal glucose uptake in young adult turkeys selected for rapid growth. Can. J. Anim. Sci. 78: 301-306. A rapid growth line (F) and a randombred control line (RBC2) of 16-wk-old unsexed turkeys were used to examine the effect of genetic selection for rapid growth on jejunal O 2 consumption, glucose uptake and apparent energetic efficiency of glucose uptake. F line had 85% greater feed-deprived body weight (FBW, kilogram) than RBC2 line (P < 0.001) at 16 wk of age and a lighter (gram/kilogram FBW) and shorter (centimeter/kilogram FBW) small intestine and jejunum (P < 0.001). Additionally, the jejunum was composed of a higher proportion (P < 0.007) of mucosal tissue. There was no difference between the lines in apparent energetic efficiency (nmoles ATP expended/nmoles glucose uptake) of jejunal active glucose uptake. These data suggest selection for rapid growth in turkeys does not result in more efficient glucose uptake from the jejunum.Key words: Genetic selection, small intestine, glucose uptake, respiration, turkey Fan, Y. K., Croom, Jr., W. J., Christensen, V. L., Bird, A. R., Daniel, L. R., McBride, B. W. et Eisen, E. J. 1998. Efficience énergé-tique apparente de l'absorption du glucose dans le jéjunum chez des dindonneaux sélectionnés pour la rapidité de la croissance. Can. J. Anim. Sci. 78: 301-306. Nous avons utilisé une souche à croissance rapide (F) et une souche témoin non sélectionnée (RBC2) de dindonneaux non sexés de 16 semaines pour examiner l'effet de la sélection génétique orientée sur la rapidité de la croissance sur la consommation de O 2 , et sur l'absorption de glucose et sur l'efficience énergétique apparente de cette absorption dans le jéjunum. À l'âge de 16 semaines, la souche F atteignait un poids corporel à jeun (PCJ) de 85 % supérieur à celui de la souche RBC2 (P < 0,001) ainsi qu'un intestin grêle, et notamment un jéjunum, plus légers (g kg -1 PCJ) et plus courts (cm kg -1 PCJ, P < 0,001). En outre, le jéjunum comportait une plus grande proportion (P < 0,007) de tissu muqueux. Les deux souches ne se distinguaient pas quant à l'efficience énergétique apparente (en nmole ATP dépensé/nmole glucose absorbé) de l'absorption de glucose dans le jéjunum. Ces observations indiquent que la sélection sur la rapidité de la croissance n'améliore pas l'efficience de l'absorption du glucose dans cette partie de l'intestin. Mots clés: Sélection génétique, intestin grêle, absorption de glucose, respiration, dindonThe rate and efficiency of postnatal growth is, in part, determined by the extent and manner of partitioning of energy between the alimentary tract and post-absorptive synthetic processes. The relationship between growth rate and the development of the digestive tract has been extensively studied in birds (Lilja 1982a,b, Lilja et al. 1985. In chickens selected for juvenile body weight by various methods, comparisons at similar chronological ages and body weights suggest that increases in weights of supply organs, especially that of the small intestine,...

show abstract

“…The paraffin sections were stained with hematoxylin and eosin. Morphometric indices for each slide were determined using computer-aided light microscope image analysis as described by Bird et al (1994). For each segment, the average measurements of 25 villus and crypts, taken from at least five different sections, were used for further analysis.…”

Section: Laboratory Analysismentioning

confidence: 99%

Influence of source and micronization of soya bean meal on growth performance, nutrient digestibility and ileal mucosal morphology of Iberian piglets

Berrocoso

Cámara

Rebollar

et al. 2014

Animal

View full text Add to dashboard Cite

The effects of inclusion in the diet of different sources of soya bean meal (SBM) on growth performance, total tract apparent digestibility (TTAD) and apparent ileal digestibility (AID) of major dietary components and mucosal ileum morphology were studied in Iberian pigs weaned at 30 days of age. From 30 to 51 days of age (phase I), there was a control diet based on regular soya bean meal (R-SBM; 44% CP) of Argentina (ARG) origin and five extra diets in which a high-protein soya bean meal (HP-SBM; 49% CP) of the USA or ARG origin, either ground (990 μm) or micronized (60 μm), or a soya protein concentrate (SPC; 65% CP) substituted the R-SBM. From 51 to 61 days of age (phase II), all pigs were fed a common commercial diet in mash form. The following pre-planned orthogonal contrasts were conducted: (1) R-SBM v. all the other diets, (2) SPC v. all the HP-SBM diets, (3) micronized HP-SBM v. ground HP-SBM, (4) HP-SBM of ARG origin v. HP-SBM of US origin and (5) interaction between source and the degree of grinding of the HP-SBM. Dietary treatment did not affect growth performance of the pigs at any age but from 30 to 51 days of age, post weaning diarrhoea (PWD) was higher ( P < 0.001) and the TTAD and AID of all nutrients were lower for pigs fed the R-SBM diet than for pigs fed the HP-SBM or the SPC diets. However, no differences between the HP-SBM and the SPC containing diets were detected for any trait. The TTAD of organic matter ( P = 0.07) and gross energy (GE) ( P = 0.05) tended to be higher for the micronized HP-SBM than for the ground HP-SBM and that of GE was higher ( P < 0.05) for US meal than for the ARG meal. Pigs fed R-SBM had lower villus height ( P < 0.01) than pigs fed HP-SBM or SPC but no differences in ileal mucosal morphology were detected between SPC and HP-SBM containing diets. It is concluded that feeding the HP-SBM or SPC-reduced PWD and improved nutrient digestibility and ileal morphology as compared with feeding the R-SBM, but had no effect on pig performance. The inclusion in the diet of added value soya products (micronized SBM or SPC) in substitution of the R-SBM increased the TTAD of all nutrients and reduced PWD but had no advantage in terms of growth performance over the use of ground HP-SBM.

show abstract

Jejunal Glucose Absorption Is Enhanced by Epidermal Growth Factor in Mice

Cited by 35 publications

References 25 publications

Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Apparent energetic efficiency of jejunal glucose uptake in young adult turkeys selected for rapid growth

Influence of source and micronization of soya bean meal on growth performance, nutrient digestibility and ileal mucosal morphology of Iberian piglets

Contact Info

Product

Resources

About