Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Odle, Jack; Zijlstra, R. T.; Donovan, Sharon M.

doi:10.2527/1996.74102509x

Cited by 138 publications

(115 citation statements)

References 97 publications

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“…However, relationships with corticoids or epinephrine secretions have never been shown to reinforce this theory [27]. Some milk factors like epidermal growth factor, insulin and insulin-like growth factor [28] or polyamines [29], could have a positive action on villous growth [30]. However, in our study, milk intake was not essential for villous growth: villi of suckling and early-weaned rabbits evolved similarly with age.…”

Section: Development Of Small Intestinal Villi and Cryptscontrasting

confidence: 43%

An early stimulation of solid feed intake slightly influences the morphological gut maturation in the rabbit

Gallois¹,

Gidenne²,

Fortun-Lamothe³

et al. 2005

Reprod. Nutr. Dev.

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-The impact of dietary factors on the gut morphological maturation is poorly documented in rabbits. The weights of the digestive segments as well as the morphology of villi and crypts along the small intestine were analysed weekly from day 14 till day 49, in two rabbit groups weaned at either 21 (W21 group, n = 12 litters) or 35 days (W35 group, n = 12 litters) of age. From 21 till 35 days, the W21 group ate 57% more solid feed than the W35 group (P < 0.01), and presented slighter body weights from day 28 till day 49 (-9%, P < 0.05). Tissue weights of the empty digestive segments, as expressed relative to the body weights, were higher in the W21 than in the W35 group from day 28 till day 49 (P < 0.001), whereas absolute tissue weights appeared similar (except for the proximal colon). From day 28 to day 49, small intestinal villi grew in height and surface area (P < 0.05) whereas the crypts deepened. Villous height followed a proximo-distal decreasing gradient from the duodenum to the ileum (P < 0.05) from day 28 onward. The villous height to width ratio changed with the beginning of significant solid feed intake: from a thin shape until day 21, villi became wider from day 28 on. The effect of weaning age on mucosal morphology was insignificant, except for the jejunal crypts whose surface area and depth were higher in the W21 group. The present results showed that morphological changes in the digestive tract of young rabbits were weakly influenced by an early stimulation of solid feed intake. gut maturation / rabbit / weaning / intestinal morphology / digestive mucosa

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Section: Development Of Small Intestinal Villi and Cryptscontrasting

confidence: 43%

An early stimulation of solid feed intake slightly influences the morphological gut maturation in the rabbit

Gallois¹,

Gidenne²,

Fortun-Lamothe³

et al. 2005

Reprod. Nutr. Dev.

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“…If a portion of the hormone is sequestered in fat globules or bound to precipitable hormone receptors associated with fat globule membranes, adequate sonication is crucial prior to leptin radioimmunoassay in order to avoid falsely high values in the fat fraction due to incomplete disruption of the fat globules (F. Rosi, unpublished data). differences in milk composition [27] and growth factor contents [21].…”

Section: Hours From Foalingmentioning

confidence: 99%

Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk

Salimei¹,

Varisco²,

Rosi³

2002

Reprod. Nutr. Dev.

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-Five Haflinger mares were hand-milked at 0 h (pre-suckle) and 6 h (postsuckle), 12, 24, 48, 72 and 96 h after parturition. Total solids, protein, fat, lactose, calculated gross energy content, leptin and non-protein nitrogen components (urea, a-amino nitrogen, creatinine and allantoin) were determined. The levels of the major constituents differed significantly in pre-suckle colostrum from subsequent samples. Leptin levels were the highest in whole (9 ng . mL -1 of immunoreactive human equivalent HE ± 0.48 ng . mL -1 , SEM) and skimmed (7.8 ng HE . mL -1 ± 0.52 ng . mL -1 , SEM) pre-suckle colostrum, declined sharply at 6 hours postpartum, and more slowly subsequently. Mean urea concentration was constant at around 5.0 mM, while a-amino N increased over the observation period and creatinine and allantoin decreased. These findings provide a further indication that mares' milk can be regarded as a functional food. mares' milk / colostrum / major constituents / leptin / non-protein nitrogenRésumé -Principaux constituants, leptine et métabolites d'azote non protéique dans le colostrum et le lait de jument. Cinq juments Haflinger ont été traitées à la main aux temps 0 (avant tétée) et 6 (après tétée), 12, 24, 48, 72 et 96 heures après le poulinage. Les paramètres évalués sur ces échantillons ont été les principaux constituants de la sécrétion mammaire (matière sèche, protéines, lipides, lactose), le contenu énergétique brut et la leptine ; en plus, on a considéré les teneurs en urée, a-aminoacides, créatinine et allantoïne. Une différence significative a été observée entre les valeurs enregistrées dans le colostrum prélevé avant la tétée et dans les autres échantillons. De même, des variations dynamiques concernant la leptine immunoréactive ont été relevées au cours de l'essai : les valeurs étaient les plus fortes dans le lait entier (9 ng . mL -1 équivalent de leptine humaine HE ± 0,48 ng . mL -1 , SEM) et dans le colostrum écrémé (7,8 ng HE . mL -1 ± 0,52 ng . mL -1 , SEM) prélevés avant la tétée. La concentration en urée était en moyenne de 5,0 mM et la concentration en azote des a-aminoacides dénote des bilans différents par rapport à celui mis en évidence pour la créatinine et pour l'allantoïne. Ces résultats contribuent à faire considérer le lait de jument comme un aliment fonctionnel.lait de jument / colostrum / constituants du lait / leptine / non-protein nitrogen Reprod. Nutr. Dev. 42 (2002) 65-72 65

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“…Na busca da base biológica para o diferencial de desempenho de recém-nascidos, verifica-se que o colostro, além de constituir-se fonte de nutrientes e de elementos de proteção, contém várias moléculas biologicamente ativas importantes para o crescimento e a sanidade animal. Entre os peptídeos bioativos presentes no colostro e no leite, destacam-se os fatores de crescimento semelhantes à insulina I e II (IGFs), que estimulam a mitogênese e a diferenciação celular (Odle et al, 1996).…”

Section: Introductionunclassified

“…Diversas evidências apontam para esta hipótese, por exemplo, a presença de receptores de IGF tipos I e II nas células epiteliais da glândula mamária e ao longo de todo o intestino do neonato, atuando no crescimento e na maturação do trato digestório durante o período pós-natal (Schober et al, 1990;LeRoith et al, 1994;Odle et al, 1996;Bühler et al, 1998;MacDonald, 1999). Pakkanen & Aalto (1997) sugeriram que uma dieta rica em IGF-I, como o colostro, provoca aumento do crescimento e da taxa de renovação celular das células intestinais. Desse modo, contribui para um intestino funcionalmente mais eficiente, elevando o aproveitamento dos componentes da dieta, favorecendo processos anabólicos e estimulando o crescimento generalizado.…”

Section: Introductionunclassified

Desenvolvimento intestinal de bezerros recém-nascidos aleitados com colostro de vacas tratadas com rbST

et al. 2007

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Com o objetivo de avaliar o efeito de diferentes níveis de IGF-I sobre os indicadores de atividade celular hepática e intestinal em bezerros recém-nascidos, 42 vacas holandesas gestantes foram aleatoriamente distribuídas em dois grupos. O grupo rbST recebeu hormônio de crescimento (500 mg rbST) e o grupo controle recebeu injeção de vitamina E. As aplicações se iniciaram aos 35 dias pré-parto e foram repetidas a cada 14 dias até o parto. Os recém-nascidos foram distribuídos aleatoriamente nas seguintes idades de abate: após o nascimento e sem a ingestão de colostro; e 2 e 7 dias de vida com ingestão de colostro das respectivas mães. O delineamento experimental utilizado foi o inteiramente casualizado, em estrutura fatorial 2 x 3, correspondendo aos grupos das mães e às idades dos bezerros. Amostras do fígado, do jejuno e do íleo foram coletadas. Os bezerros do grupo rbST apresentaram, no jejuno, menores níveis de DNA e proteína aos 7 dias de vida, enquanto a concentração de proteína nesse grupo aumentou aos 2 dias de vida. Esse efeito também foi observado na relação proteína/RNA. No grupo controle, o aumento de proteína foi verificado no 7º dia. Os indicadores de atividade celular analisados sugerem que o IGF-I adicional no colostro de vacas tratadas com rbST teve participação na maturação celular intestinal dos bezerros, sendo determinante no comportamento da primeira geração de enterócitos.

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Intestinal effects of milkborne growth factors in neonates of agricultural importance.

Cited by 138 publications

References 97 publications

An early stimulation of solid feed intake slightly influences the morphological gut maturation in the rabbit

An early stimulation of solid feed intake slightly influences the morphological gut maturation in the rabbit

Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk

Desenvolvimento intestinal de bezerros recém-nascidos aleitados com colostro de vacas tratadas com rbST

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