Jaundice in Pediatric Visceral Leishmaniasis (Kala-azar) Patients

Rashid, Akm Mamunur; Mamun, Abdullah Al; Rasul, CH; Afrafuzzaman,; Hossain, Mokter; Rahman, MM

doi:10.3329/jom.v8i1.1374

Cited by 6 publications

(6 citation statements)

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“…[14][15][16][17][18][19] Similarly, studies conducted in India and Bangladesh also reported abnormally high liver inflammatory enzymes like ALT, AST, and ALP in VL patients. 6,20 This may be attributed to the levels of particular circulating cytokines during the inflammatory processes observed in active VL disease could be a determinant and consequence of severe liver disease. 17 The liver function alteration might be due to hepatomegaly and the generation of immune complex in VL patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Alteration of Clinical Chemistry Parameters Among Visceral Leishmaniasis Patients in Western Tigrai, Ethiopia, 2018/2019: A Comparative Cross-Sectional Study</p>

Tesfanchal

Gebremichail

Belay

et al. 2020

IDR

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Background: Visceral leishmaniasis causes alterations of lipid metabolism and it is associated with hypocholesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life-threatening hepatitis are associated with visceral leishmaniasis. Kidney damage is frequently associated with increased morbidity and mortality in visceral leishmaniasis patients. Methods: A cross-sectional study was carried out to assess the alterations of clinical chemistry parameters among visceral leishmaniasis patients attending Kahsay Abera and Mearg hospitals, Northwest Ethiopia. A total of 100 visceral leishmaniasis patients and 100 healthy controls without visceral leishmaniasis were selected by using convenient sampling techniques. Data were entered and analyzed using statistical package for social sciences (SPSS) version 23. Results: Results were showed that the mean value of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and triglyceride was significantly higher in visceral leishmaniasis patients than in apparently healthy controls, but the mean value of serum urea and total cholesterol was significantly lower in visceral leishmaniasis patients than healthy controls. Conclusion: The finding of this study concluded that visceral leishmaniasis causes significant alterations of clinical chemistry tests like liver and lipid profile tests compared to healthy controls.

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Section: Discussionmentioning

confidence: 99%

<p>Alteration of Clinical Chemistry Parameters Among Visceral Leishmaniasis Patients in Western Tigrai, Ethiopia, 2018/2019: A Comparative Cross-Sectional Study</p>

Tesfanchal

Gebremichail

Belay

et al. 2020

IDR

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“…In this study, the patient presented jaundice (++/4). Although jaundice and ascites are considered rare features in VL 20 , other studies have demonstrated that different degrees of jaundice has been observed as an usual clinical presentation, particularly in children 21 , 22 .…”

Section: Discussionmentioning

confidence: 95%

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Narciso

Carvalho

Campos³

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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American visceral leishmaniasis (VL) is a vector-borne disease transmitted by some species of phlebotomine sandflies from the genus Lutzomyia. This neglected tropical zoonosis shows increasing urbanization process, since the end of the 1980s. After the emergence of foci of the disease in urban areas, VL has assumed an important role in public health. Although VL is widely prevalent in several parts of the world, diagnosing the illness is still difficult. We present a case of a 12-year-old girl with a history of recurrent fever, anorexia, cachexia, chronic fatigue, weight loss, left palpebral unilateral edema, persistent cough and pancytopenia. A diagnosis of VL was performed using a reference immunochromatographic rapid test. Identification of the infecting protozoan was directly obtained by PCR of bone marrow. The patient responded favorably to treatment using liposomal amphotericin B. This is the first report of human visceral leishmaniasis in the city of Lavras in the South of Minas Gerais State. This first report of VL highlighted the need of maintenance of permanent surveillance and control programs in the city of Lavras, including the active search of sandflies, human and canine cases. The current situation of Lavras should also be taken as an alert to other near cities where favorable eco-epidemiological conditions may exist.

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“…In a recent Bangladeshi study, it is found that initial diagnosis of chronic liver disease was made in 36% of the patient with visceral leishmaniasis & same study also mentions that 9% of Kala-azar patient was initially thought to have congenital hemolytic anaemia. 4 In India, multiple cases are reported where visceral leishmaniasis was mistaken for chronic liver disease & treatment was delayed which ultimately proved to be fatal. 5,6 In these cases, correct diagnosis was delayed mainly due to absence of features characteristic of visceral leishmaniasis, such as fever.…”

Section: Discussionmentioning

confidence: 99%

“…Kala-azar often involves the liver due to effect of LD body itself or immunological response against it leading to altered biochemistry of liver. 4 We investigated thoroughly pursuing both lines of diagnoses. Upper GI endoscopy &fibroscan of liver were normal.…”

Section: Discussionmentioning

confidence: 99%