Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects Aβ42-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model

Anupama, Kizhakke Purayil; Olakkaran, Shilpa; Antony, Anet; Raghu, Shamprasad Varija; Gurushankara, Hunasanahally Puttaswamygowda

doi:10.1016/j.neuro.2022.02.011

Cited by 10 publications

(6 citation statements)

References 69 publications

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“…At present, plant therapy for AD has attracted more and more attention because of its comprehensive effects and less side effects ( Mithu et al, 2014 ; Sun et al, 2014 ; Yan et al, 2017 ; Martínez-Coria et al, 2019 ; Singh et al, 2019 ; Baranowska-Wójcik et al, 2020 ; Hosseini et al, 2021 ; Nowak et al, 2021 ; Sohn et al, 2021 ; Anupama et al, 2022 ). The mystery fruit, which we used in this study, has also received more attention due to its good antioxidant properties, including lowering cholesterol ( Huang et al, 2020 ), antidiabetic effects ( Obafemi, et al, 2019 ), reducing serum uric acid levels ( Shi et al, 2016 ), and anti-oxidative damage ( Chen et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…Also, because of the clinical trial failures and multiple sides of synthetic drugs, the development of phytotherapy has received close attention from the public and the scientific community ( Vegh, et al, 2019 ). Many foods and nutritional drugs are claimed to have memory-improving effects, including Ginkgo biloba ( Singh, et al, 2019 ; Nowak, et al, 2021 ), dihydromyricetin ( Martínez-Coria, et al, 2019 ), linalool ( Hosseini et al, 2021 ), fig leaves ( Sohn et al, 2021 ), Schisandra polysaccharides ( Sun et al, 2014 ), Nardostachys jatamansi ( Anupama et al, 2022 ), tea ( Baranowska-Wójcik, et al, 2020 ), Forsythia ( Yan et al, 2017 ), curcumin ( Mithu et al, 2014 ), and acidic polysaccharose ( Mithu et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Huang

Xue²,

Chen³

et al. 2023

Front. Pharmacol.

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Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Huang

Xue²,

Chen³

et al. 2023

Front. Pharmacol.

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“…In the control group, male and female flies maintained separately were fed exclusively with 5% yeast and food dye. Survival, negative geotaxis, chemotaxis and phototaxis assays for IAA-fed male and female flies of D. melanogaster were carried out using standard protocols 30 – 32 described in SI. Strains were identified based on full-length 16S rRNA gene sequence analysis as described earlier 33 .…”

Section: Methodsmentioning

confidence: 99%

Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster

Aziz,

Ramesh,

Suchithra

et al. 2024

Sci Rep

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Several bacteria of environmental and clinical origins, including some human-associated strains secrete a cross-kingdom signaling molecule indole-3-acetic acid (IAA). IAA is a tryptophan (trp) derivative mainly known for regulating plant growth and development as a hormone. However, the nutritional sources that boost IAA secretion in bacteria and the impact of secreted IAA on non-plant eukaryotic hosts remained less explored. Here, we demonstrate significant trp-dependent IAA production in Pseudomonas juntendi NEEL19 when provided with ethanol as a carbon source in liquid cultures. IAA was further characterized to modulate the odor discrimination, motility and survivability in Drosophila melanogaster. A detailed analysis of IAA-fed fly brain proteome using high-resolution mass spectrometry showed significant (fold change, ± 2; p ≤ 0.05) alteration in the proteins governing neuromuscular features, audio-visual perception and energy metabolism as compared to IAA-unfed controls. Sex-wise variations in differentially regulated proteins were witnessed despite having similar visible changes in chemo perception and psychomotor responses in IAA-fed flies. This study not only revealed ethanol-specific enhancement in trp-dependent IAA production in P. juntendi, but also showed marked behavioral alterations in flies for which variations in an array of proteins governing odor discrimination, psychomotor responses, and energy metabolism are held responsible. Our study provided novel insights into disruptive attributes of bacterial IAA that can potentially influence the eukaryotic gut-brain axis having broad environmental and clinical implications.

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“…Because scopolamine-induced amnesia was reversed, the memory improvement could be due to stimulation of cholinergic transmission in the brain. As a result, Nardostachys jatamansimay show to be an effective memoryrestorative agent in treating dementia in the elderly [52] .…”

Section: Jatamansi (Nardostachys Jatamansi)mentioning

confidence: 99%

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

Raut,

Joshi,

Waghmare

2024

J Pharmacogn Phytochem

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Alzheimer's disease (AD) is a neurodegenerative condition that severely impairs memory and cognitive function. As the illness worsens, it produces verbal and visuospatial difficulties, as well as behavioural issues like rage, sadness, and indifference. The current treatment for Alzheimer's disease has no known cure, symptomatic relief can retard the progression with memory loss and other symptoms. However, natural remedies have a therapeutic effect on several symptoms of this disease, including dementia and Alzheimer's disease. The current review intends to provide an overview of herbs, such as Shankhpushpi, Brahmi, Pumpkin, Ashwagandha, Almond, Kesar, Sage, Amla, Turmeric and many more that have been documented to have CNS activity with respect to AD and could be used to treat symptoms, slow the development of AD.

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Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects Aβ42-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model

Cited by 10 publications

References 69 publications

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

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