Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Abstract

Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD.

The MET growth signaling complex drives Alzheimer’s Disease-associated brain pathology in aged Shugoshin 1 mouse cohesinopathy model

“…The molecular docking predictions showed that the seed compounds were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. Thus, the seeds are discussed to potentially play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway [36]. Ginkgo biloba L. leaves have shown potentially beneficial effects for people with dementia, when it is administered at doses greater than 200mg/day for at least 5 months [37].…”

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking

“…This enables the PI 3 K/Akt signaling pathway to operate normally, avoiding neuroin ammation, oxidative stress, and other pathological processes. 75 STAT3 encodes a protein that belongs to the STAT family of proteins. It plays a crucial role in various cellular processes such as cell growth and apoptosis.…”