Japanese Butterbur (<i>Petasites japonicus</i>) Leaves Increase Hepatic Oxidative Stress in Male Rats

Han, Kyu‐Ho; Sekikawa, Mitsuo; Shimada, Kaoru; Lee, Chi H.; Hashimoto, Naoto; Fukushima, Michihiro

doi:10.1271/bbb.120294

Cited by 5 publications

(5 citation statements)

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“…In ancient oriental medicine, the flower buds were used as apophlegmatic, antitussive, antifebrile, antiasthma, and detoxification agents, and the young leaves were harvested and used as raw materials and raw vegetables (Choi, 2002;Bang et al, 2005). Current pharmaceutical studies have revealed antioxidant, anti-inflammatory, anticancer, anti-allergic, and anticoagulant effects of P. japonicus (Choi, 2002;Han et al, 2012;Hwang et al, 2015). In addition, a number of chemical constituents including sesquiterpenes, triterpenes, and various types of phenolic compounds (e.g.…”

Section: Introductionmentioning

confidence: 99%

Changes in the phenolic compounds profile, antioxidant and anti-melanogenic activity from organs of Petasites japonicas under different extraction methods

Ji¹,

Yoo²,

Jin³

et al. 2020

Rev.Mex.Ing.Quim.

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Section: Introductionmentioning

confidence: 99%

Changes in the phenolic compounds profile, antioxidant and anti-melanogenic activity from organs of Petasites japonicas under different extraction methods

Ji¹,

Yoo²,

Jin³

et al. 2020

Rev.Mex.Ing.Quim.

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“…The rhizomes and PL contain amounts of toxic pyrrolizidine alkaloids (PA), which have demonstrated carcinogenic and mutagenic potential [27]. Recent research indicated that PLs may cause adverse reactions in rats based on enhanced postprandial oxidative stress [28]. Additionally, a methanol extract of PL revealed hepatotoxicity [29].…”

Section: Resultsmentioning

confidence: 99%

Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur

Park

Lim²,

Lee

et al. 2021

Foods

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Butterbur (Petasites japonicus (Siebold & Zucc.) Maxim) leaves are available to consumers in the marketplace, but there is no guarantee that they are safe for human consumption. Previously, we demonstrated that hot water extracts of P. japonicus leaves (KP-1) had anti-inflammatory properties and attenuated memory impairment. However, data regarding KP-1 toxicity are lacking. This study assessed the safety of KP-1 by examining oral and genotoxic effects using in vivo and in vitro tests, respectively. In a single oral dose toxicity and two-week repeated oral dose toxicity study, we observed no toxicologically significant clinical signs or changes in hematology, blood chemistry, and organ weights at any dose during the experiment. Following a thirteen-week repeated oral dose, toxicity, hyperkeratosis, and squamous cell hyperplasia of the limiting ridge in the stomach were observed. The no observable adverse effect level (NOAEL) was found to be 1250 mg/kg/day in male and female rats. However, hyperkeratosis and hyperplasia were not considered to be of toxicological significance when extrapolating the NOAEL to humans because the limiting ridge in the stomach is species-specific to rats. Therefore, in our study, the NOAEL was considered to be 5000 mg/kg/day when the changes in the stomach’s limiting ridge were discounted. Moreover, in vitro bacterial reverse mutations and chromosomal aberrations in Chinese hamster lung (CHL) cells and the in vivo micronucleus in Institute of cancer research (ICR) mice assays showed that KP-1 possessed no mutagenicity. Although additional research is required, these toxicological evaluations suggest that KP-1 could be safe for human consumption.

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“…Possible Adverse Effects of P. japonicus and Attention to Pyrrolizidine Alkaloids As described above, Han et al (39) reported an increase in hepatic TBARS values after diets including a 5% acetone extract of P. japonicus leaf powder, as revealed by the presence of pyrrolizidine alkaloids. Pyrrolizidine alkaloids are toxic and can cause liver damage and cancer.…”

Section: Anti Cancer Effect Of P Japonicusmentioning

confidence: 89%

“…Cholesterol increased on liver cirrhosis and blood urea nitrogen directed post in liver function also decreased. (37) In contrast, Han et al (39) have reported an increase in hepatic TBARS values and glutathione reductase and glutathione Stransferase activities and hepatic cytochrome mRNA expression following diets with 5% acetone extract of P. japonicus leaf powder, as revealed by the presence of pyrrolizidine alkaloids. Therefore, considering that a high amount of antioxidants were required to suppress the acute reaction, the amount of the toxic compound present in the P. japonicus flower bud extracts should be considered.…”

mentioning

confidence: 91%

Antioxidant compounds of <i>Petasites japonicus</i> and their preventive effects in chronic diseases: a review

Hiemori-Kondo

2020

J. Clin. Biochem. Nutr.

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Petasites japonicus ( P. japonicus ) is a plant of the Asteraceae family. Its roots and stems have been used for the treatment or the prophylaxis of migraine and tension headache as a traditional Chinese medicine in Japan and Korea. Sesquiterpenoids, lignans, and flavonoids are components of P. japonicus . Regarding the biological activity of P. japonicus , its anti-allergic effect has been researched extensively using IgE antigen-stimulated degranulation of RBL-2H3 cells or passive cutaneous anaphylaxis reaction in experimental animal models. The study of the antioxidant activity of P. japonicus was initiated approximately 15 years ago using in vitro assays. In addition, its in vivo effect has also been examined in animal models with induced oxidative injury. Moreover, recently, many types of antioxidant compounds have been rapidly and simultaneously identified using the liquid chromatography–mass spectrometry technique. The number of reports on the other functions of this plant, such as its neuroprotective and anti-inflammatory effects, has been increasing. In this review, I summarized the studies of functional foods derived from P. japonicus , which may provide a basis for the development of potential functional foods. Finally, I discuss the future research avenues in this field.

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Japanese Butterbur (Petasites japonicus) Leaves Increase Hepatic Oxidative Stress in Male Rats

Cited by 5 publications

References 40 publications

Changes in the phenolic compounds profile, antioxidant and anti-melanogenic activity from organs of Petasites japonicas under different extraction methods

Changes in the phenolic compounds profile, antioxidant and anti-melanogenic activity from organs of Petasites japonicas under different extraction methods

Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur

Antioxidant compounds of <i>Petasites japonicus</i> and their preventive effects in chronic diseases: a review

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