Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer

Gheisari, Farshid; Shafiee, Mostafa; Abbasi, Milad; Jangjou, Ali; Izadpanah, Peyman; Vaez, Ahmad; Amani, Ali Mohammad

doi:10.1080/03602532.2021.1878530

Cited by 13 publications

(6 citation statements)

References 68 publications

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“…They are composed of two or more parts that show a discrepancy in their physico-chemical properties and these parts are often contrary in nature [ 28 ]. This phenomenon facilitates their applications in drug delivery systems where a single material with several domains can concurrently realize multidrug loading and work as an perfect carrier [ 29 , 30 ]. The anisotropic structure of Janus particles also makes them an ideal choice for theranostics [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Regular Polymeric Microspheres with Highly Developed Internal Structure and Remarkable Thermal Stability

2021

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In this study, the synthesis and characterization of permanently porous polymeric microspheres was presented. The microspheres were obtained via suspension polymerization using diverse functional monomers, such as 4,4′-bis(methacryloyloxymethylphenyl)sulphone, 1,4-bis(methacryloyloxymethyl)benzene, 4,4′-bis(methacryloyloxymethylphenyl)methane, N-vinylpyrrolidone, ethylene glycol dimethacrylate, and divinylbenzene as a co-monomer. As porogenic solvents, toluene and chlorobenzene were applied. The main aim of the research was to synthesize polymers having a highly developed internal structure and a good thermal stability. The synthesized materials were characterized by ATR-FTIR, scanning electron microscopy, a size distribution analysis, a low-temperature nitrogen adsorption–desorption method, differential scanning calorimetry, and thermogravimetry coupled with FTIR and inverse gas chromatography. It was found that, depending on the functional monomer, regular microspheres with a specific surface area in the range of 418–746 m2/g can be successfully synthesized. Moreover, all the synthesized copolymers showed a good thermal stability. In helium, they exhibited 5% mass losses at temperatures over 300 °C, whereas in air these values were only slightly lower. In addition, the presence of miscellaneous functional groups promoted diverse kinds of interactions. Therefore, the microspheres can be possibly use in many adsorption techniques including high temperature processes.

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Section: Introductionmentioning

confidence: 99%

Regular Polymeric Microspheres with Highly Developed Internal Structure and Remarkable Thermal Stability

2021

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“…Inorganic Janus particles composed of metallic nanoparticles and oxide particles [ 29 ] or transition metal NPs and oxides [ 30 ] display high catalyst activity as the boundary of metals and oxide components serves as a site of binding for catalyst activation along with oxygen sorption [ 22 ]. Hence, this property of these particles can be utilized for biosensing as they prove to be superior to the existing core or shell particles as the multiple components present in the single particle interact independently with the external environment stimulus upon exposure to it [ 31 ].…”

Section: Properties Of Janus Nanoparticlesmentioning

confidence: 99%

“…Ranging from optical switchable devices, optical probes, self-propelling particles, catalysts, emulsifiers, disease detection, drug discovery and delivery, environmental monitoring, analysis of disease-causing microorganisms and markers that are indicators of disease in bodily fluids (blood, urine, saliva, sweat) and so forth (3). Moreover, various dyes and fluorescent particles (e.g., quantum dots), fluorophores and other such luminescent molecules can aid in the production of Janus particles for bio-imaging and bio-sensing purposes [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in Janus nanoparticle-based biosensing platforms

2022

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Nanoparticles have aided in the development of nano-based sensors for diagnostic applications. However, use of nanoparticles in the development of sensing devices for multiple analyte detection is constrained due to their inability to detect several analytes with a single type of nanoparticle. The term “Janus particle” refers to micro or nanoscale particles that have been divided into sections or compartments, each of which has a distinct set of chemical or physical properties, producing multifunctional particles endowed with distinctive qualities. Furthermore, Janus particles have the ability to perform multiple functions within a single particle at the same time, with no interference from adjacent sections. This review focuses on the use of Janus particles in the fabrication of biosensors as well as in the investigation of various properties endowed by these Janus particles for their use as biosensors. It also discusses the various types of Janus particle-based biosensors that are currently available. Finally, the limitations of Janus particles in sensor technologies and their future scope have been discussed. Graphical abstract

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“…Self-propelling Janus particles, for example, with a permanent biphasic asymmetry, have emerged as a rich chemical platform for the exploration of active matter 2 . In the absence of mobility and any imposed flow, Janus particles (JPs) self-assemble into oligomers of various geometries and sizes depending on the interactions between JPs and the viscous solvent [3][4][5] , with tunable functions for biomedical engineering applications 1,[6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Tunable Hydrophobicity on the Collective Hydrodynamics of Janus Particles under Flows

Fu¹,

Ryham²,

Quaife³

et al. 2022

Preprint

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Active colloidal systems with non-equilibrium self-organization is a long-standing, challenging area in biology. To understand how hydrodynamic flow may be used to actively control self-assembly of Janus particles (JPs), we use a model recently developed for the many-body hydrodynamics of amphiphilic JPs suspended in a viscous background flow (JFM, 941, 2022). We investigate how various morphologies arise from tuning the hydrophobic distribution of the JP-solvent interface. We find JPs assembled into uni-lamella, multi-lamella and striated structures. To introduce dynamics, we include a linear shear flow and a steady Taylor-Green mixing flow, and measure the collective dynamics of JP particles in terms of their (a) free energy from the hydrophobic interactions between the JPs, (b) order parameter for the ordering of JPs in terms of alignment of their directors, and (c) strain parameter that captures the deformation in the assembly.We characterize the effective material properties of the JP structures and find that the uni-lamellar structures increases orientation order under shear flow, the multilamellar structure behaves as a shear thinning fluid, and the striated structure possesses a yield stress. These numerical results provide insights into dynamic control of non-equilibrium active biological systems with similar self-organization.

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Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer

Cited by 13 publications

References 68 publications

Regular Polymeric Microspheres with Highly Developed Internal Structure and Remarkable Thermal Stability

Regular Polymeric Microspheres with Highly Developed Internal Structure and Remarkable Thermal Stability

Recent advancements in Janus nanoparticle-based biosensing platforms

Effects of Tunable Hydrophobicity on the Collective Hydrodynamics of Janus Particles under Flows

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