Nanoparticles have aided in the development of nano-based sensors for diagnostic applications. However, use of nanoparticles in the development of sensing devices for multiple analyte detection is constrained due to their inability to detect several analytes with a single type of nanoparticle. The term “Janus particle” refers to micro or nanoscale particles that have been divided into sections or compartments, each of which has a distinct set of chemical or physical properties, producing multifunctional particles endowed with distinctive qualities. Furthermore, Janus particles have the ability to perform multiple functions within a single particle at the same time, with no interference from adjacent sections. This review focuses on the use of Janus particles in the fabrication of biosensors as well as in the investigation of various properties endowed by these Janus particles for their use as biosensors. It also discusses the various types of Janus particle-based biosensors that are currently available. Finally, the limitations of Janus particles in sensor technologies and their future scope have been discussed.
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Introduction: Water bore diseases like diarrhea, dysentery etc. are one of the major causes of death in many countries like India, Bangladesh, Indonesia etc. According to World Development Report (1992), 80% of the diseases in the world are related to water. According to a book published by World Health Organization and Organization for Economic Cooperation and Development, around 2.2 million of the 3.3 million water related deaths are caused due to diarrhea. The major reason for this problem is the unavailability of potable water to the masses. Absence of harmful chemicals, pathogenic microorganisms is some of the characteristic features of potable water. To reduce the risk of
This review focuses on nerve degeneration, owing to different nerve diseases or injuries being a major problem nowadays. The low regenerative capacity of the nerve leads to primary brain injury. Clinical therapies available were only able to stabilize lesion progression. Reversal of degeneration process and functional regeneration promotion were brought about by the implementation of nanotechnology to biology allowing cell tissue integration. Nanomaterials implemented in the delivery of drugs and bioactive materials treats specifically targeted cells. Nanomaterials made in contact with cells lead to stem cell therapy promoting stem cell differentiation and neurogenesis. Nanomaterials were also reviewed to be used as a potential scaffold material, being a neuroprotectant in nerve regeneration.
Over the past few years, nanoparticles have been widely used in therapeutic applications. It is well acknowledged that the shortcomings of conventional treatments have been improved by nanoparticles. The advantages and drawbacks of inorganic nanocarriers such as metal nanoparticles and quantum dots have been extensively studied. Although carbon nanotubes have been touted as a prominent medication delivery method, their physicochemical characteristics viz. low water solubility, limited circulation time, etc restrict their use. In comparison to hard matter tubes like carbon and other inorganic matter, organic nanotubes have better physiological properties such as improved blood stability, longer circulation time, high serum solubility, etc. The current study focuses on recent developments in the use of organic nanotubes for drug delivery and the utilization of their structural features. The soft, organic material that build up these nanotubes has a synergistic effect on biocompatibility and lowers cytotoxicity thus proving suitable for the potential use as drug delivery carrier. The goals of this review are to identify the characteristics that support the creation of new drug delivery systems and to shed light on current advancements that have been reported in the literature. The paper also includes discussion of the difficulties in using these organic nanotubes for applications in drug delivery as well as the potential for future research in this field.
Biological synthesis of silver nanoparticles (AgNPs) has been an area of research to avoid the harmful effects of the toxic chemicals used in its synthesis on our health and environment. In the present study, a novel strain of Pseudomonas aeruginosa-RTAC 11 isolated from soil
was used for the synthesis of AgNPs. Characterization of the synthesized nanoparticles like UV-vis spectroscopy confirmed the synthesis of AgNPs through a signature peak at 420 nm. Fourier Transform Infrared (FTIR) spectroscopic analysis revealed the capping of AgNPs by proteins through signature
functional groups. The nano-size of the particles were confirmed using scanning electron microscopy (SEM). The AgNPs showed good antibacterial activity against Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 6538, thus indicating an excellent antibacterial agent.
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