Janus Micelles

Erhardt, Rainer; Böker, Alexander; Zettl, Heiko; Kaya, Håkon; Pyckhout‐Hintzen, Wim; Krausch, Georg; Abetz, Volker; Müller, Axel H. E.

doi:10.1021/ma000670p

Cited by 399 publications

(381 citation statements)

References 47 publications

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“…Recently, Perro et al 53 reviewed the developments in the field of Janus particles during the last fifteen years, describing various strategies to obtain Janus-type particles using polymer precursors. One strategy is based on the self-assembly of ABC terpolymers in bulk 54,55 or in solution. 56 Another uses the electrostatic interactions of AB and CD diblock copolymers, which leads to inter-polyelectrolyte complexes.…”

Section: Janus-type Nanoparticle Assembly At Fluid Interfacesmentioning

confidence: 99%

Self-assembly of nanoparticles at interfaces

et al. 2007

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Developments in the assembly of nanoparticles at liquid-liquid interfaces are reviewed where the assemblies can be controlled by tuning the size of the nanoparticles and the chemical characteristics of the ligands. Both synthetic and biological nanoparticles are discussed. By controlling the type of ligands, uniform and Janus-type nanoparticles can be produced where, at liquid-liquid interfaces, subsequent reactions of the ligands can be used to generate crosslinked sheets of nanoparticles at the interface that have applications including novel encapsulants, filtration devices with well-defined porosities, and controlled release materials. By controlling the size and volume fraction of the nanoparticles and the chemical nature of the ligands, nanoparticle-polymer composites can be generated where either enthalpy or entropy can be used to control the spatial distribution of the nanoparticles, thereby, producing auto-responsive materials that self-heal, self-corral assemblies of nanoparticles, or self-direct morphologies. Such systems hold great promise for generating novel optical, acoustic, electronic and magnetic materials.

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Section: Janus-type Nanoparticle Assembly At Fluid Interfacesmentioning

confidence: 99%

Self-assembly of nanoparticles at interfaces

et al. 2007

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“…[ [258][259][260] Spherical Polystyrene Poly(propylene carbonate) Poly(9,9-dioctylfl uorene-2,7-diyl-co-bis-N , Nfl uorene-2,7-diyl-co-bis-N , Nphenyl-1,4-phenylenedi amine) (PFB) Poly(9,9-dioctylfl uorene-2,7-diyl-cobenzothiadiazole) (F8BT) Miniemulsion, phase separation…”

Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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“…Fig. 4 illustrates CSC micelles at pH < 5 that have been stained by RuO 4 vapor, in such a way that the more compact PS core is more contrasted than the stretched P2VP shell, so giving rise to a 'frog egg' structure. The second method was based on specific interactions between the P2VP shell and phosphotungstic acid as shown in Fig.…”

Section: Tab 1 Molecular Weights Of the Investigated Copolymersmentioning

confidence: 99%

“…Although ABC triblocks are precursors of very complex selfassembled structures in the bulk [2], little is known about their self-association in selective solvents of one (or two) of the constitutive blocks. In addition to 'three-layer' micelles in water [3], formation of asymmetrical micelles was reported in organic solvents [4]. These 'Janus' micelles consist of a crosslinked polybutadiene core and a corona with 'southern' polystyrene and 'northern' poly(methyl methacrylate) hemispheres.…”

Section: Introductionmentioning

confidence: 99%

pH Dependence of the morphology of aqueous micelles formed by polystyrene-block-poly(2-vinylpyridine)-blockpoly( ethylene oxide) copolymers

Willet

Varshney²,

Zhang³

et al. 2002

E-Polymers

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Abstract:The morphology of micelles formed by two polystyrene-block-poly(2-vinylpyridine)-block-poly(ethylene oxide) (PS-b-P2VP-b-PEO) copolymers was studied in water by dynamic light scattering and transmission electron microscopy. Spherical micelles were observed that consist of a PS core, a P2VP shell and a PEO corona. The characteristic size of core, shell and corona depends on the copolymer composition. An important increase in micellar size occurs at pH < 5 as a result of P2VP block protonation. The reversibility of this pH effect depends on copolymer composition, too. The conformation of the PEO block plays an important role in this pH driven morphological transition.

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Janus Micelles

Cited by 399 publications

References 47 publications

Self-assembly of nanoparticles at interfaces

Self-assembly of nanoparticles at interfaces

Design Advances in Particulate Systems for Biomedical Applications

pH Dependence of the morphology of aqueous micelles formed by polystyrene-block-poly(2-vinylpyridine)-blockpoly( ethylene oxide) copolymers

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