“…A fermentation system for studying the indole source in lolitrem biosynthesis in the context of its tryptophan-derived co-metabolite ergovaline (5) would be attractive, but is probably not yet available in sufficient product yield. However, several model systems are available in addition to that for nodulisporic acid (7) in the particular Nodulisporium sp., namely paxilline (11) alone in P. paxilli (Ibba et al, 1987), penitrem A (2) and pennigritrem (12) together in P. nigricans (Penn et al, 1992), penitrem A (2) and nigrifortine (18) together in P. nigricans (Laws and Mantle, 1985;Mantle et al, 1984), and janthitrems alone in P. janthinellum (Penn et al, 1993). Experiments conducted with 13 C and 14 C in parallel could also aid clarification of tryptophan's role as an indole source.…”