The role of tryptophan as a biosynthetic precursor of indole-diterpenoid fungal metabolites: Continuing a debate

Mantle, Peter G.

doi:10.1016/j.phytochem.2008.11.004

Cited by 17 publications

(18 citation statements)

References 27 publications

(33 reference statements)

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“…Further, isoprenylations would then decorate the western and south moiety of the indole to afford the natural product skeleton. These findings are sharply contrasting with the admitted tryptophan origin of indole-diterpenes which biosynthesis therefore deserves further studies [46]. Indeed, it had previously been shown that isotopically labeled tryptophan was incorporated in the NAA-related compounds paspaline and penitrem A by Claviceps paspali and Penicillium crustosum, respectively.…”

Section: Studies In Natural Products Chemistrymentioning

confidence: 72%

Diversity and Ecological Significance of Fungal Endophyte Natural Products

Prado¹,

Li²,

Nay³

2012

Bioactive Natural Products

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Section: Studies In Natural Products Chemistrymentioning

confidence: 72%

Diversity and Ecological Significance of Fungal Endophyte Natural Products

Prado¹,

Li²,

Nay³

2012

Bioactive Natural Products

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“…When the aetiology of BEN and its tumours is satisfactorily explained the facts about causal agent(s) and their quantitative exposure will be seen to fit comfortably with the rigorous metaphysical requirements of the classic Koch’s Postulates in defining a disease determinant. An example of this, concerning a natural toxicant and a mysterious morbidity, was the case of proving step by step that trace amounts of the lolitrem B metabolite of a cryptic obligate fungal endophyte in grass is the cause of “ryegrass staggers” in agricultural ruminants [50]. …”

Section: Discussionmentioning

confidence: 99%

Comparative 1H NMR Metabolomic Urinalysis of People Diagnosed with Balkan Endemic Nephropathy, and Healthy Subjects, in Romania and Bulgaria: A Pilot Study

Mantle

Modalca²,

Nicholls

et al. 2011

Toxins

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1H NMR spectroscopy of urine has been applied to exploring metabolomic differences between people diagnosed with Balkan endemic nephropathy (BEN), and treated by haemodialysis, and those without overt renal disease in Romania and Bulgaria. Convenience sampling was made from patients receiving haemodialysis in hospital and healthy controls in their village. Principal component analysis clustered healthy controls from both countries together. Bulgarian BEN patients clustered separately from controls, though in the same space. However, Romanian BEN patients not only also clustered away from controls but also clustered separately from the BEN patients in Bulgaria. Notably, the urinary metabolomic data of two people sampled as Romanian controls clustered within the Romanian BEN group. One of these had been suspected of incipient symptoms of BEN at the time of selection as a ‘healthy’ control. This implies, at first sight, that metabolomic analysis can be predictive of impending morbidity before conventional criteria can diagnose BEN. Separate clustering of BEN patients from Romania and Bulgaria could indicate difference in aetiology of this particular silent renal atrophy in different geographic foci across the Balkans.

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“…Antibiotic resistant bacteria are rapidly emerging worldwide [1]. The various biological active heterocyclic compounds, the indole derivatives are the key structural feature commonly found in natural products [2,3] and bioactive molecules, such as tryptophan [4], tryptamine [5], and auxin [6]. Furthermore, it has been reported that sharing of the indole 3-carbon in the formation of spiroindoline derivatives highly enhances biological activity [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

Pansare¹,

Shelke²

2020

Heterocycles - Synthesis and Biological Activities

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A highly efficient protocol was developed for the synthesis of 3-(indoline-1carbonyl)-N-(substituted) benzene sulfonamide analogs with excellent yields. The new 3-(indoline-1-carbonyl)-N-(substituted) benzene sulfonamide derivatives (4a-g and 5a-g) were evaluated in vitro anticancer activity against a series of different cell lines like A549 (lung cancer cell), HeLa (cervical), MCF-7 (breast cancer cell) and Du-145 (prostate cancer cell) respectively. The results of the anticancer activity data revealed that most of the tested compounds showed IC 50 values from 1.98 to 9.12 μM in different cell lines. Compounds 4b, 4d, 5d, and 5g were the most potent, with IC 50 values ranging from 1.98 to 2.72 μM in different cell lines.

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The role of tryptophan as a biosynthetic precursor of indole-diterpenoid fungal metabolites: Continuing a debate

Cited by 17 publications

References 27 publications

Diversity and Ecological Significance of Fungal Endophyte Natural Products

Diversity and Ecological Significance of Fungal Endophyte Natural Products

Comparative 1H NMR Metabolomic Urinalysis of People Diagnosed with Balkan Endemic Nephropathy, and Healthy Subjects, in Romania and Bulgaria: A Pilot Study

Synthesis and Anticancer Evaluation of Benzenesulfonamide Derivatives

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