Jak3 Inhibition With Cp-690,550 Prevents Obliterative Bronchiolitis in a Rat Tracheal Transplant Model.

Rousvoal, Geraldine; Zhang, S; Berry, Gerald J.; Lau, M; Larson, Madelyn R.; Si, M-s; Flores, M; Changelian, Paul S.; Reitz, Beverly A.; Borie, Dominic C.

doi:10.1097/00007890-200407271-00133

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“…These include inhibition of Janus kinase (JAK) 3, with a resulting effect on platelet-derived growth factor, the modulation of transforming growth factor (TGF)-b 1 and of agents influencing vascular endothelial growth factor all in rat transplant models [18,19]. Studies in the murine model using pirfenidone, which also affects TGF-b 1 , have demonstrated a delay in the onset, as well as a reduction in the severity, of OB when administered early in the post-transplant period, suggesting that pirfenidone may be a candidate drug to be evaluated in human subjects [20].…”

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confidence: 99%