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Salman, Baher; Hassan, Ahmed; Sultan, Sultan; Tophill, Paul; Halawa, Ahmed

doi:10.6002/ect.2016.0193

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…One advantage of bladder recycling is that it can predict which defunctionalized bladders would improve after resuming normal cycling [ 22 ]. It is safer to transplant into a normal bladder, but if the bladder is abnormal, the risk of a poor outcome can be minimised by conducting appropriate pretransplant investigations and planning optimal management [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies support pretransplant bladder evaluation and pretransplant correction of LCB, especially in patients whose bladder dysfunction results from urological etiologies [ 4 – 6 ]. Moreover, a study report that LCB in kidney transplant patients leads to decrease graft survival and increase risk of complications such as urinary tract infection [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with low-compliance bladder in end-stage renal disease patients and development of a clinical prediction model for urodynamic evaluation: the DUDi score

Tangpaitoon

Swatesutipun

2022

Int Urol Nephrol

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Objectives To investigate factors associated with low-compliance bladders (LCB) in pretransplant patients with end-stage renal disease (ESRD) and develop a clinical prediction model for urodynamic studies. Methods This study was a prospective cohort study. Patients with ESRD on the renal transplantation waiting list were recruited and underwent the urodynamic study. Demographics data, predictor factors related to the bladder compliance such as underlying disease of the lower urinary tract disease (LUTD), duration of urine < 250 mL/day, type and duration of renal replacement therapy (RRT), urine volume per day and urodynamic study information were collected. Univariable and multivariable logistic regression models were used to assess the independence of explanatory factors, then we developed the clinical prediction model. Results One hundred fifty-two patients participated in the study: 94 patients in the normal bladder group and 58 patients in LCB group. Demographic data were not significantly different between the two groups, except diabetes. Cystometric capacity, detrusor pressure, compliance were significantly different. From the univariate analysis, DM status, duration of RRT, and passing < 100 mL of urine per day were related to LCB. We named the prediction model, the DUDi score based on the predictors ( D uration of RRT, U rine volume/day, Di abetes). Higher scores predicted a higher risk of low-compliance bladder [ P value = 0.464 according to the Hosmer–Lemeshow test, and the AUC was 0.87 (95% CI 0.81–0.92)]. Conclusions Our clinical prediction model is easy to use and provides a high predictive value that is appropriate for patients who have no known LUTD to identify low-compliance bladder. Trial registration number and date of registration for prospectively registered trials This study was approved by the Thai Clinical Trials Registry Committee on 09 February 2021. The TCTR identification number is TCTR20210209006.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors associated with low-compliance bladder in end-stage renal disease patients and development of a clinical prediction model for urodynamic evaluation: the DUDi score

Tangpaitoon

Swatesutipun

2022

Int Urol Nephrol

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“…В то же время, по данным некоторых авторов, нарушенная функция мочевого пузыря, сопровождающаяся уменьшением его емкости, повышенным внутрипузырным давлением и снижением комплаентности существенно не сказывается в негативную сторону на результатах ТП при сроках наблюдения до 10 лет [69]. Функционирование трансплантата в группах реципиентов почки с дисфункцией мочевого пузыря и нормально функционирующим органом в течение 1, 3 и 5 лет составляло 90%, 88% и 82% в группе с дисфункцией мочевого пузыря и 97%, 91% и 87% в группе без дисфункции органа соответственно.…”

Section: Review Articles and Lecturesunclassified

Current possibilities of improving the results of kidney transplantation in patients of the older age group, including those with an aggravated urological history

Khubutiya¹,

Rzhevskaya²,

Лисенок³

2021

Transplantologiâ (Mosk.)

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Introduction. All over the world and in Russia, the number of patients requiring dialysis therapy and kidney transplantation for chronic renal failure in the end-stage of the renal disease is increasing. In many countries of the world, the number of dialysis patients over 60 years of age accounts for 30 to 45% of all patients with chronic renal failure. Meantime, taking into account the improved methods for early diagnosis of chronic renal failure and the treatment methods for chronic kidney disease, including the renal replacement therapy, we can expect an increase in the number of elderly potential kidney transplant recipients. The likelihood of receiving a renal graft in elderly patients is significantly lower than in young recipients. Elderly patients are known to have a higher risk of death while waiting for a kidney transplant due to higher morbidity and lethality on dialysis. For this reason, the urgency of increasing the availability of kidney transplantation in elderly patients is growing over time. One of the solutions can be the use of kidneys from suboptimal donors with a far from ideal graft quality, but which could meet the needs for transplant care of the older age group of patients. The older age of a recipient entails a certain risk of developing a graft dysfunction due to the presence of concomitant diseases, and the potential risk increases even more with kidney transplants from expanded criteria donors. If a reduced functional reserve of kidneys removed from donors with extended criteria is identified, two-kidney transplantation is possible, which provides fairly good long-term results. To reduce the risk of a kidney graft loss, a careful selection of recipients is necessary, taking into account their co-morbidities, including the presence of urological diseases that impair the function of the upper and lower urinary tract. Their timely identification and correction makes it possible to raise the availability of kidney transplantation for elderly patients and improve its results. This review presents the results of the studies conducted in various world transplant centers, covers the mortality rates, kidney graft and recipient survival rates.The study purpose was to summarize the actual data and the results of the study on kidney transplantation in elderly patients with urological pathology.

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“…В то же время по данным некоторых авторов нарушенная функция мочевого пузыря, сопрово-ждающаяся уменьшением его емкости, повышенным внутрипузырным давлением и снижением комплаентности, существенно не сказывается или не сказывается в значительной степени негативно на результатах трансплантации почки при сроках наблюдения до 10 лет [10].…”

Section: Introductionunclassified

Burdened urological history as a risk factor in kidney transplantation for older age group recipients

Khubutiya¹,

Khubutiya²,

Евсеев³

et al. 2022

Transplantologiâ (Mosk.)

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Introduction. Chronic renal failure develops more often in elderly patients after previous repeated urological operations. Urological diseases are an important additional factor that multiply complicates kidney transplantation due to the need for preliminary correction of existing disorders. Not to mention the fact that the recipient's advanced age contributes to the risk of developing graft dysfunction due to the presence of concomitant diseases that worsen the immediate and long-term results of transplantation. Material and methods. We carried out the analysis of clinical observations and studies performed in 124 patients who underwent cadaveric renal allotransplantation at the N.V. Sklifosovsky Research Institute for Emergency Medicine, including from suboptimal donors. Of these, 69 (55.6%) recipients older than 60 years were included in the main group (group 1), and 55 recipients younger than 60 years (44.4%) -in the comparison group (group 2). From the patients of group 1, patients with urological diseases that led to the development of terminal chronic renal failure, or with previously undergone surgeries for urological diseases (subgroup 1A, 43 patients) were isolated. The remaining 26 patients who did not have urological diseases were put in subgroup 1B. Results. The analysis showed that in the early postoperative period in the recipients of group 1, complications developed in almost all the patients (80 complications in 64 of 69 patients, that is, 92.8% of patients in this group), whereas in group 2, complications developed only in 30.9% of patients (27 complications in 17 of 55 patients). At the same time, on average, 1.2 complications per 1 patient were noted in group 1, and 0.5 complications per 1 patient in group 2, a significant part of the complications occurred in the subgroup of patients with a burdened urological history (subgroup 1A). Late complications also developed statistically significantly more often (almost 2 times) in recipients with a burdened urological history. Conclusions. Complications of the early and late postoperative period develop statistically significantly more often in elderly recipients. The presence of a burdened urological history in elderly recipients significantly increases the risk of early and late postoperative complications.

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Untitled

Cited by 6 publications

References 17 publications

Factors associated with low-compliance bladder in end-stage renal disease patients and development of a clinical prediction model for urodynamic evaluation: the DUDi score

Factors associated with low-compliance bladder in end-stage renal disease patients and development of a clinical prediction model for urodynamic evaluation: the DUDi score

Current possibilities of improving the results of kidney transplantation in patients of the older age group, including those with an aggravated urological history

Burdened urological history as a risk factor in kidney transplantation for older age group recipients

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