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doi:10.18632/oncotarget.v10i40

Cited by 2 publications

(1 citation statement)

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“…PGC1α is frequently found to be overexpressed in CRC tissues and cell lines. It serves as a key energy mediator, and is induced by aerobic glycolysis ( 22 ) and hypoxia ( 23 ) in CRC cells. Interestingly, lactate metabolites generated from these processes contribute to the elevation of PGC1α mRNA levels in cancer cells ( 24 , 25 ).…”

Section: Roles Of Pgc1α In Cancer Cellsmentioning

confidence: 99%

From metabolism to malignancy: the multifaceted role of PGC1α in cancer

Wang,

Peng,

Yang

et al. 2024

Front. Oncol.

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PGC1α, a central player in mitochondrial biology, holds a complex role in the metabolic shifts seen in cancer cells. While its dysregulation is common across major cancers, its impact varies. In some cases, downregulation promotes aerobic glycolysis and progression, whereas in others, overexpression escalates respiration and aggression. PGC1α’s interactions with distinct signaling pathways and transcription factors further diversify its roles, often in a tissue-specific manner. Understanding these multifaceted functions could unlock innovative therapeutic strategies. However, challenges exist in managing the metabolic adaptability of cancer cells and refining PGC1α-targeted approaches. This review aims to collate and present the current knowledge on the expression patterns, regulators, binding partners, and roles of PGC1α in diverse cancers. We examined PGC1α’s tissue-specific functions and elucidated its dual nature as both a potential tumor suppressor and an oncogenic collaborator. In cancers where PGC1α is tumor-suppressive, reinstating its levels could halt cell proliferation and invasion, and make the cells more receptive to chemotherapy. In cancers where the opposite is true, halting PGC1α’s upregulation can be beneficial as it promotes oxidative phosphorylation, allows cancer cells to adapt to stress, and promotes a more aggressive cancer phenotype. Thus, to target PGC1α effectively, understanding its nuanced role in each cancer subtype is indispensable. This can pave the way for significant strides in the field of oncology.

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