From metabolism to malignancy: the multifaceted role of PGC1α in cancer
Yue Wang,
Jianing Peng,
Dengyuan Yang
et al.
Abstract:PGC1α, a central player in mitochondrial biology, holds a complex role in the metabolic shifts seen in cancer cells. While its dysregulation is common across major cancers, its impact varies. In some cases, downregulation promotes aerobic glycolysis and progression, whereas in others, overexpression escalates respiration and aggression. PGC1α’s interactions with distinct signaling pathways and transcription factors further diversify its roles, often in a tissue-specific manner. Understanding these multifaceted… Show more
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