J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Du, Bulin; Liu, Ruiqi; Qu, Chunrong; Qian, Kun; Suo, Yang; Wu, Fengxia; Chen, Hongda; Li, Xuena; Li, Yaming; Liu, Hongguang; Cheng, Zhen

doi:10.1016/j.mtbio.2022.100366

Cited by 15 publications

(17 citation statements)

References 51 publications

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“…The synthesized Crizotinib-IR808 was water-insoluble. To extend its utility in physiological media, the nonantigenic, biocompatible, and clinically used BSA protein is employed as the matrix to load with Crizotinib-IR808 to fabricate Crizotinib-IR808@BSA NPs. − The detailed procedure is described in the Materials and Methods section.…”

Section: Resultsmentioning

confidence: 99%

Albumin-Based Cyanine Crizotinib Conjugate Nanoparticles for NIR-II Imaging-Guided Synergistic Chemophototherapy

Cui

et al. 2023

ACS Appl. Mater. Interfaces

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Colorectal cancer (CRC) is presently the third deadliest cancer in the world. This malignant cancer usually precedes the progression of precancerous lesions, and it is challenging to distinguish its nuanced morphological changes. Molecular-based near-infrared-II (NIR-II) fluorescence imaging can effectively recognize lesion targets to improve image contrast and increase early tumor detection compared with traditional wide-light screening endoscopy. c-Met has been determined to be overexpressed in advanced stages of CRC and is considered to be a potent tumor biomarker. Herein, based on the well-targeted inhibitory effect of Crizotinib on c-Met positive tumor cells, the dye IR808 was covalently combined with the drug molecule Crizotinib, resulting in the synthesis of a NIR fluorescent probe Crizotinib-IR808 targeting c-Met positive tumor cells. Then, water-insoluble Crizotinib-IR808 was fabricated by using bovine serum albumin (BSA) nanoparticles (NPs) with excellent biocompatibility and biosafety. The prepared Crizotinib-IR808@BSA NPs showed tumor targeting capability as well as use for noninvasive biomedical vascular NIR-II imaging with intraoperative real-time NIR-II imaging to guide tumor resection. Under 808 nm laser irradiation, Crizotinib-IR808@BSA NPs exhibited synergistic chemophototherapy effects on tumors. In conclusion, this innovative imaging-mediated multifunctional combination therapy strategy with good c-Met targeting ability may provide a new approach for colorectal cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Albumin-Based Cyanine Crizotinib Conjugate Nanoparticles for NIR-II Imaging-Guided Synergistic Chemophototherapy

Cui

et al. 2023

ACS Appl. Mater. Interfaces

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“…complexed IR‐1061 with human serum albumin (HSA) to form J‐aggregates (Figure 8A). [20] The resulting IR‐1061@HSA complexes showed a slightly red‐shifted absorption band, indicating the formation of J‐aggregates. The NIR‐II fluorescence of these complexes allowed for the visualization of tumor vascular networks and real‐time intraoperative tumor resection under guidance.…”

Section: Ir1061‐based Aggregatesmentioning

confidence: 99%

The Aggregates of Near‐Infrared Cyanine Dyes in Phototherapy

Huang

et al. 2023

ChemMedChem

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Cyanines in the near‐infrared region are a typical example of a classic fluorescent dye that has garnered significant attention and widespread use in the life sciences and biotechnology. Their character to form assemblies or aggregates has inspired the development of various functional cyanine dye aggregates in phototherapy. This article provides a brief summary of the strategies used to prepare these cyanine dye aggregates. The reports in this concept suggest that the self‐assembly of cyanine dyes can enhance their photostability, opening up new possibilities for their application in phototherapy. This concept may encourage researchers to explore the development of functional fluorescent dye aggregates further.

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“…Given that Cy-PA NPs exhibited better photothermal performance compared to commercial Indocyanine Green nanoparticles as well as most of NIR-II organic nanoparticles, we further investigate its performance in dual-tumor model. [44][45][46][47] Accordingly, we established the dual-tumor model. Dual-tumor-bearing mice were obtained by injecting B16 cells into the right and left hind limbs of mice.…”

Section: In Vivo Ptt In Dual-tumor Modelmentioning

confidence: 99%

NIR‐II Cyanine Nanoparticles for Imaging‐Guided Tumor Targeting Photothermal Therapy with Vitamin C Enhanced Efficacy

Huang

Jiang

et al. 2023

Advanced Therapeutics

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Cyanine dyes in the near‐infrared‐II (NIR‐II) region are among the most promising photothermal agents, due to their high photothermal conversion efficiency, strong tumor targeting capability, and deep tissue penetration. The application of cyanine‐based photothermal agents remains limited, however, due to the invasive nature and spread of tumors as well as the potential for inflammatory responses during the treatment process. In this work, a naphtho[cd]indolium‐based heptamethine cyanine with NIR‐II emission is utilized to prepare PEGylated nanoparticles for studies of photothermal treatment. The results demonstrate that the nanoparticles have excellent NIR‐II imaging and tumor targeting capabilities. As a result of the light harvesting property of naphtho[cd]indolium‐based heptamethine cyanine, these nanoparticles demonstrate a photothermal conversion efficiency of 61%. The tumor‐targeting properties of these nanoparticles enable them to accumulate effectively at limbs containing tumors. Photothermal therapy shows almost complete disappearance of all tumors after eight days of treatment. In addition, hematoxylin‐eosin stains (H&E stains) of major organs show no discernible lesions throughout the treatment process. Furthermore, simultaneous injection of natural vitamin C during the treatment significantly improves the therapeutic effect of photothermal therapy.

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J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Cited by 15 publications

References 51 publications

Albumin-Based Cyanine Crizotinib Conjugate Nanoparticles for NIR-II Imaging-Guided Synergistic Chemophototherapy

Albumin-Based Cyanine Crizotinib Conjugate Nanoparticles for NIR-II Imaging-Guided Synergistic Chemophototherapy

The Aggregates of Near‐Infrared Cyanine Dyes in Phototherapy

NIR‐II Cyanine Nanoparticles for Imaging‐Guided Tumor Targeting Photothermal Therapy with Vitamin C Enhanced Efficacy

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