Ixodic Tick-Borne Borreliosis in the Krasnodar Krai

Мошкова, Д. Ю.; Avdeeva, Marina G.; Блажняя, Л. П.

doi:10.25207/1608-6228-2019-26-6-49-60

Cited by 3 publications

(5 citation statements)

References 8 publications

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“…В Южно-Уральском регионе высока доля безэритемных форм с неврологическими расстройствами, доброкачественным гепатитом [20]. В Краснодарском крае ИКБ чаще протекает в эритемной форме без выраженных симптомов интоксикации, а безэритемные формы -с поражением как центральной, так и периферической нервной системы [7].…”

Section: таблица этапы отбора литературных источниковunclassified

“…Диагностика эритемных форм ИКБ облегчается при наличии сведений о присасывании клеща или нахождении больного в местах с риском нападением клещей. Кольцевидная эритема при ИКБ чаще локализуется на нижних конечностях, режена туловище [7].…”

Section: кожные проявления иксодового клещевого боррелиозаunclassified

“…Развитие гипертрофического типа диастолической дисфункции миокарда наблюдается у 38% больных в периоде реконвалесценции [8]. У части пациентов, несмотря на отсутствие жалоб со стороны сердечно-сосудистой системы, нами наблюдались изменения на ЭКГ в виде нарушения проводимости [7].…”

Section: поражение сердечно-сосудистой системыunclassified

“…В начальном периоде заболевания при диссеминации боррелий чаще поражается центральная нервная система с развитием серозного менингита. При нейроборрелиозе для ликвора характерен лимфоцитарный плеоцитоз с повышением уровня белка и нормальным уровнем глюкозы [7].…”

Section: поражение нервной системыunclassified

“…ИКБ представляет серьезную проблему для большинства территорий субъектов Российской Федерации. В связи с повсеместным увеличением численности и активности клещей, связанным с изменением климата, ландшафта, миграцией животных и птиц, а также активным отдыхом людей, наблюдается расширение ареала возбудителей ИКБ в РФ, происходит появление новых очагов и расширение границ старых, распространение ИКБ в южные регионы [6,7].…”

Section: Introductionunclassified

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Clinical mimics and diagnostic challenges in tick-borne borreliosis: a systematic review

Блажняя

Avdeeva

Мошкова

2021

Kuban. nauсh. med. vestnik

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Background. Ixodes tick-borne borreliosis (TBB) is a clinically multifaceted disease posing a serious threat in most territories of the Russian Federation. New TBB outbreaks emerge and spread to the country’s south.Objectives. The review highlights the TBB clinical diversity to physicians in order to improve the diagnosis quality and opportune aid. It focuses on the early and late clinical presentation of localised and disseminated polysystemic TBB.Methods. Sources were mined in the MEDLINE, PubMed and national electronic databases (Сyberleninka, eLibrary, etc.) with keywords “tick-borne borreliosis” [клещевой боррелиоз], “Lyme disease” [болезнь Лайма], “Lyme arthritis” [Лайм-артриты], neuroborreliosis [нейроборрелиоз] for the period of 2014–2020. Selected impactive publications within 2007–2013 were also included. Research was considered eligible if borreliosis was diagnosed using specific techniques like immune-enzyme assays, immunoblotting or PCR.Results. TBB is a common and cross-disciplinary situation. The disease may progress occult or manifest in a variety of forms, from annular erythema to cardiac, peripheral and central nervous system involvement or arthritis. The polysystemic nature of lesions, often long-term of the tick bite, forces multiple specialist visits ending with misdiagnoses, late aetiotropic therapy and transition into a chronic phase through ignorance of the patient’s epidemiological record. Some patients may have the acute phase followed by irreversible neurological damage associated with memory loss, cognitive decline, arthrosis and sclerotic skin change reducing the quality of life.Conclusion. TBB can be mimicked by therapeutic, neurological, skin and ophthalmic illnesses, which warrants the physician’s attention to the epidemiological record and knowledge of specific diagnostic techniques. Further research is necessary into the pathogenesis and clinical presentation of chronic TBB and its residual manifestations.

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Section: таблица этапы отбора литературных источниковunclassified

Section: кожные проявления иксодового клещевого боррелиозаunclassified

Section: поражение сердечно-сосудистой системыunclassified

Section: поражение нервной системыunclassified

Section: Introductionunclassified

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Clinical mimics and diagnostic challenges in tick-borne borreliosis: a systematic review

Блажняя

Avdeeva

Мошкова

2021

Kuban. nauсh. med. vestnik

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Lymphocyte enzymes as an indicator of immune response activity in ixodid tick-borne borreliosis

Avdeeva

Moshkova²,

Blazhnyaya³

et al. 2023

Epidemiology and Infectious Diseases

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Aim of the study was to determine the pathogenetic mechanisms of the infectious and inflammatory process in the erythemal form of acute ITB based on the study of the activity of lysosomal enzymes of lymphocytes, the level of IL-2 and the clinical manifestations of the disease. Methods: The main group is represented by 609 patients hospitalized at the Krasnodar City Clinical Hospital for the period 20102019. The study group consisted of 45 patients with erythemal form of acute ITB. In the dynamics of the disease, the level of IL-2 and the cytochemical activity of acid phosphatase (AP) and nonspecific alpha-naphthyl esterase (-NAE) of lymphocytes were determined. Results: during the height of ITB, a decrease in the cytochemical activity of hydrolytic enzymes of lymphocytes was noted in comparison with the control group. IL-2 levels had a high dispersion and were associated with the clinical manifestations of the disease. A low level of IL-2 correlated with a decrease in the activity of -NAE lymphocytes. During the period of convalescence, there was a restoration of the enzymatic activity of lymphocytes, an increase in the number of cells with a pronounced activity of -NAE, typical of T-lymphocytes with killer activity. Conclusion: The hydrolytic enzymes of the lysosomes of CP and -NAE lymphocytes make it possible to judge the intensity of intracellular metabolic processes and, in combination with the clinical symptoms of the disease and the activity of IL-2, are an indicator of the state of the immune process, supplementing the results of traditional immunological studies in patients with the erythema form of acute ixodid tick-borne borreliosis. The predominance of enzymatically inactive forms of T-lymphocytes in the acute period of the disease reflects a certain deficiency of the T-cell immunity.

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About the characteristics of «internal» and «external» epidemiological risks in the territory Rostov region

Кононенко

Водяницкая

2020

Med. vestn. Ûga Ross.

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Objective: to identify some «internal» and «external» risks that are signifi cant for the Rostov region and calculate their quantitative characteristics.Materials and methods: materials for «internal» risks in the administrative territories of the Rostov region served materials FBUZ «Center of hygiene and epidemiology in the Rostov region» on the incidence of Crimean hemorrhagic fever (KGL) and West Nile (LSN) during the period 2004 – 2017 as a whole across the Rostov region and the slit regions, the data of the regional law «About administrative-territorial structure of Rostov region», the Results of the national census. To determine the «internal» risks, we used the guidelines developed by us «Methodology for assessing the territory of the subject of the Russian Federation on the integral indicator of population morbidity with arbovirus infections», approved by Th e decision of the Academic Council of the Rostov-on-Don anti-plague Institute of Rospotrebnadzor and approved by the Director.Results: based on the results of the ranking of the territory of the Rostov region on the incidence of KGL and LDL, the degree of epidemiological risk was assessed and «risk territories» were identifi ed for these nosologies, which can serve as a basis for risk management — making scientifi cally based management decisions. To calculate the magnitude of the «external» risk and further spread of the disease, you can use various methods to assess the probability of adverse development of the epidemiological situation under the infl uence of various risk factors. Epidemiological risk can also be characterized by multiplying the individual risk by the population exposed to risk factors.Conclusions: identifi cation and calculation of risk levels depending on risk factors will help determine the scope of management decisions, and the specifi cation of risk factors will allow you to develop specifi c measures to reduce risk.

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Ixodic Tick-Borne Borreliosis in the Krasnodar Krai

Cited by 3 publications

References 8 publications

Clinical mimics and diagnostic challenges in tick-borne borreliosis: a systematic review

Clinical mimics and diagnostic challenges in tick-borne borreliosis: a systematic review

Lymphocyte enzymes as an indicator of immune response activity in ixodid tick-borne borreliosis

About the characteristics of «internal» and «external» epidemiological risks in the territory Rostov region

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