IV Diretrizes Brasileiras de Hipertensão Arterial

Mion, Décio; Machado, Carlos A.; Gomes, Marco Antônio Mota; Nobre, Fernando; Júnior, Osvaldo Kohlmann; Amodeo, Celso; Praxedes, José Nery; Pascoal, Istenio; Magalhães, Lucélia C.

doi:10.1590/s0066-782x2004001000004

Cited by 48 publications

(12 citation statements)

References 21 publications

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“…48 Previous studies showed that treatment with enalapril did not improve the serum and urinary levels of creatinine, 43 which corroborates with the results shown in this study. In patients with renovascular hypertension, the treatment with enalapril may cause reduced glomerular filtration that increases creatinine levels; however, in the long term, its nephroprotective effects prevail, 49 which explains the treatment with enalapril not having improved creatinine levels. We demonstrated that ASE treatment improved renal function parameters evidenced by restoration of serum and urinary levels of creatinine and urea, urinary volume, and proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Açaí Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril

Vilhena

Cunha

Jorge

et al. 2021

Journal of Cardiovascular Pharmacology

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This study aimed to determine if açai seed extract (ASE) could reverse pre-existing cardiovascular and renal injury in an experimental model of renovascular hypertension (2 kidney, 1 clip, 2K1C). Young male rats (Wistar) were used to obtain 2K1C and sham groups. Animals received the vehicle, ASE (200 mg/kg/d), or enalapril (30 mg/kg/d) in drinking water from the third to sixth week after surgery. We evaluated systolic blood pressure by tail plethysmography, vascular reactivity in the rat isolated mesenteric arterial bed (MAB), serum and urinary parameters, plasma inflammatory cytokines by ELISA, MAB expression of endothelial nitric oxide synthase and its active form peNOS by Western blot, plasma and MAB oxidative damage and antioxidant activity by spectrophotometry, and vascular and cardiac structural changes by histological analysis. ASE and enalapril reduced the systolic blood pressure, restored the endothelial and renal functions, and decreased the inflammatory cytokines and the oxidative stress in 2K1C rats. Furthermore, both treatments reduced vascular and cardiac remodeling. ASE substantially reduced cardiovascular remodeling and recovered endothelial dysfunction in 2K1C rats probably through its antihypertensive, antioxidant, and anti-inflammatory actions, supplying a natural resource for the treatment of renovascular hypertension.

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Section: Discussionmentioning

confidence: 99%

Açaí Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril

Vilhena

Cunha

Jorge

et al. 2021

Journal of Cardiovascular Pharmacology

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“…The disease was considered active when IGF-1 was above the normal value for age and gender, even when using cabergoline, octreotide, or pegvisomant; considered controlled when the use of these drugs kept blood concentrations of IGF-1 within the normal range; and considered cured when the concentrations of this hormone were within the normal range without the use of these drugs. Hypertensive participants were considered as those with blood pressure equal to or >140 × 90 mmHg, or those using anti-hypertensive drugs (25). A participant was considered to have diabetes mellitus type 2 when glycemia was equal to or higher than 125 mg/dL, or 2 h post oral glucose tolerance test higher than 199 mg/dL or HbA1 levels equal to or higher 6.5%, or if he/she was using hypoglycemic drugs (26).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Cognitive-Behavioral Therapy on Acromegalics After a 9-Month Follow-Up

2019

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Introduction: The quality of life of acromegalics is compromised. Treatment with the “Think healthy and feel the difference” technique has been described as effective in the improvement of the quality of life of these patients in the short term. However, its effectiveness in the long term needs to be evaluated. Objective: The purpose of this study was to evaluate whether the good results obtained from the “Think healthy and feel the difference” technique in the short term persists in the long term, after the end of the treatment. Method: This is a non-randomized longitudinal study with 23 acromegalic divided into two groups: an intervention group with 10 patients and a control group with 13 patients. The intervention itself covered nine group sessions, organized weekly, using a technique called “Think healthy and feel the difference.” The control group did not receive the aforementioned treatment. The Short Form 36 Question Health Survey (SF-36) and the Beck Depression Inventory were administered before the sessions began, at the end of the nine therapy sessions and at the 9-month follow-up. Results: At the end of the treatment, the results of the SF-36 showed improvement in the mental health of the intervention group compared to the control group. The effects of therapy were maintained at the 9 month follow-up. Conclusion: Cognitive-behavioral therapy, applied in a group format, can improve the quality of life of acromegalic patients in the short- and long-term.

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“…inadequada, que pode agravar o quadro clínico. A não compreensão da terapia prescrita pode ser uma das razões pelas quais medicamentos reconhecidamente eficazes sob condições controladas, se tornam inefetivos quando utilizados na prática clínica habitual (29).…”

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Implementação De Um Protocolo De Cuidado Farmacêutico Em Idosos Hipertensos Em Uma Farmácia Comunitária De Jaraguá Do Sul, Brasil

Reis

Rosa

Neis

2023

Infarma

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O presente estudo teve como objetivo implementar um modelo de cuidado farmacêutico para monitoramento do tratamento medicamentoso de idosos hipertensos em uma farmácia comunitária no município de Jaraguá do Sul, SC, Brasil. Foi utilizado o Método Dáder para seguimento farmacoterapêutico de uma amostra aleatória simples de 15 indivíduos, de ambos os sexos, com idade entre 60 e 81 anos, diagnosticados com hipertensão. Os pacientes foram acompanhados por um período de três meses, nos quais foram aplicados questionários sobre hábitos de vida, história farmacoterapêutica, adesão ao tratamento além de identificar e classificar os problemas relacionados aos medicamentos (PRM). Em todos os encontros foram verificados os níveis pressóricos, para acompanhar o efeito dos fármacos prescritos. Ao final, foi possível observar que houve redução dos níveis pressóricos de dois de grau grave e um de grau moderado para leve, um com pressão arterial limítrofe atingiu o nível de normalidade e apenas um registrou aumento da pressão arterial passando de grau leve para moderado. Os PRM tipo 1 e 4 foram os mais detectados. As intervenções educativas foram priorizadas com enfoque na orientação sobre o uso correto dos medicamentos, além do esclarecimento de dúvidas sobre medidas não farmacológicas, como controle de peso, redução do consumo de álcool e sal. Esses resultados reforçam a importância do cuidado farmacêutico para melhora da qualidade de vida dos hipertensos, melhoria dos níveis pressóricos e controle de possíveis complicações decorrentes da doença ou do uso inadequado dos fármacos.

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IV Diretrizes Brasileiras de Hipertensão Arterial

Abstract: Realização Work performed by

Cited by 48 publications

References 21 publications

Açaí Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril

Açaí Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril

The Effect of Cognitive-Behavioral Therapy on Acromegalics After a 9-Month Follow-Up

Implementação De Um Protocolo De Cuidado Farmacêutico Em Idosos Hipertensos Em Uma Farmácia Comunitária De Jaraguá Do Sul, Brasil

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