iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit

Zhang, Shidong; Wang, Dongsheng; Dong, Shuwei; Yang, Zhiqiang; Yan, Zuoting

doi:10.1016/j.jep.2017.05.022

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…BHT (750 mg dry extract/kg body weight) up-regulated F-actin, coronin, Rac, and MHC I, acting in phagocytosis and cross-presentation, in the high fever model produced in rabbits by LPS injection. These results suggested that BHT might promote pyrogen clearance by promoting antigen phagocytosis, degradation, and cross-presentation in the liver [ 67 ]. The antipyretic effect of Shigao might be attributed to the combined action of various trace elements.…”

Section: Application Of Tcm For Treatment Of Covid-19mentioning

confidence: 99%

Reflections on treatment of COVID-19 with traditional Chinese medicine

et al. 2020

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Coronavirus disease 2019 (COVID-19) pandemic is spreading rapidly around the globe. By the establishment of an integrative system combining both traditional Chinese medicine (TCM) and western medicine, China has achieved good clinical efficacy in the prevention and control of the pandemic. The advantages of TCM in the treatment of COVID-19 include effective relief of symptoms, retarding the development from mild and moderate to severe, improvement of cure rate, reducing death rates, and promotion of rehabilitation. Besides, according to the different severity levels of individual cases, the National Health Commission of the People's Republic of China issued treatment guidelines that provide corresponding prescriptions for patients. From the perspective of TCM, this review aims to analyze the role of a variety of TCM prescriptions in the treatment of COVID-19, focusing on the analysis of the "Three TCM prescriptions and three medicines" recommended by the Chinese authorities during the pandemic. We expect that this review will provide insights into the prevention and treatment of COVID-19 with TCM.

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Section: Application Of Tcm For Treatment Of Covid-19mentioning

confidence: 99%

Reflections on treatment of COVID-19 with traditional Chinese medicine

et al. 2020

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“…The proteomics was also employed for uncovering the molecular mechanisms of TCM treatments on other diseases. For example, von Willebrand factor, protein Z-dependent protease inhibitor, alpha-2-macroglobulin, and apolipoprotein C-III were considered as potential targets for Shen-Zhi-Ling in treating depression [41]; Bu-Fei Yi-Shen formula might alter the expression of proteins involved in oxidative stress and focal adhesion to treat chronic obstructive pulmonary disease [42]; Bai-Hu-Tang might fight against lipopolysaccharide fever syndrome by up-regulating F-actin, coronin, nicotinamide adenine dinucleotide phosphate oxidase and major histocompatibility complex class I [43]; Red ginseng could modulate antioxidant-related proteins ubiquitin carboxyl-terminal hydrolase isozyme L1, heat shock 70 kDa protein, fructose-bisphosphate aldolase against aging [44], etc.…”

Section: Differential Proteomics For Exploring the Action Mechanisms mentioning

confidence: 99%

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Yang

Gao

2019

Chin Med

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Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes their functions. In this paper, the applications of differential proteomics in exploring the action mechanisms of TCMs on various diseases including cancers, cardiovascular diseases, diabetes, liver diseases, kidney disorders and obesity, etc. were reviewed. Furthermore, differential proteomics in studying of TCMs identification, toxicity, processing and compatibility mechanisms were also included. This review will provide information for the further applications of differential proteomics in TCMs studies.

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“…The pyrogen acts on the body to induce fever and thermoregulatory center of the body dysfunction (Roth and Blatteis, 2014;Zhang et al, 2017). Pyrogens can be classified into exogenous and endogenous pyrogen (Jia et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Huangteng Soluble Powder on Endogenous Pyrogen and Central Mediators of Fever Induced by Lipopolysaccharide in Chicken

Liu¹

2019

PVJ

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The objective of this study was to understand the effect of Huangteng Soluble Powder (HTSP) on endogenous pyrogen and central mediators of fever induced by Lipopolysaccharide (LPS) in chicken. The model was established, and 90 chickens were randomly assigned into 6 groups, including Group I (control), Group II (injected with LPS), Group III (administered with Banqing Granules once a day for 3 days after 5 h post injection of LPS), Group IV, V and VI (administered with HTSP once a day for 3 days after 5 h post injection of LPS). The temperature was measured at different time periods, and samples were collected at 5 h post injection of LPS and 12 h, 24 h after the administration of HTSP. The results showed that HTSP significantly decreased the temperature of fever chicken as compared to Group II. The levels of IL-1, IL-6, TNF-α in serum and Prostaglandin E2 (PGE2), cyclic adenosine monophosphate (cAMP) in hypothalamus in Group II significantly increased at 5 h post injection of LPS and the mRNA expression levels of PGE2 and cAMP were also increased significantly in Group II as compared to control respectively. Furthermore as compared with Group II, the levels of IL-1, IL-6 in serum and PGE2, cAMP in the hypothalamus in Groups III, IV, V and VI decreased after 12 h and 24 h, the levels of TNF-α in serum in Group III and V decreased after 12 h and 24 h, and the mRNA expression levels of PGE2 and cAMP of Group V were significantly decreased at the end of the administration. In conclusion, HTSP can attenuate the LPS-induced fever by diminishing the levels of IL-1, IL-6 and TNF-α in serum and the levels of PGE2 and cAMP in the hypothalamus and inhibiting the mRNA expression of PGE2 and cAMP. , 2019. Protective effect of huangteng soluble powder on endogenous pyrogen and central mediators of fever induced by lipopolysaccharide in chicken. Pak Vet J, 39(2): 187-192. http://dx.

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iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit

Cited by 5 publications

References 33 publications

Reflections on treatment of COVID-19 with traditional Chinese medicine

Reflections on treatment of COVID-19 with traditional Chinese medicine

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Protective Effect of Huangteng Soluble Powder on Endogenous Pyrogen and Central Mediators of Fever Induced by Lipopolysaccharide in Chicken

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