Itraconazole Versus Griseofulvin in the Treatment of Tinea Capitis: A Double‐blind Randomized Study in Children

López-Gómez, Sara; Palacio, Amalia del; Cutsem, J. Van; Cuétara, María Soledad; Iglesias, L.; Rodriguez-Noriega, A.

doi:10.1111/j.1365-4362.1994.tb01525.x

Cited by 112 publications

(62 citation statements)

References 5 publications

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“…Itraconazole is a lipophilic triazole which, like ketoconazole, inhibits the 14-demethylase and since its action is more selective on the fungus enzyme, itraconazole is consequently less hepatotoxic. A double-blind comparative study with griseofulvin revealed that the two drugs had similar efficacy but there was a better tolerance for itraconazole [5]. Other studies have confirmed the high efficacy and tolerability of itraconazole in tinea capitis [6, 7, 8].…”

Section: Introductionmentioning

confidence: 92%

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

et al. 1998

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Background: Tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. The clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. Terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin. Objective: The objective of the present study was to test the sensitivity of different species of dermatophytes towards terbinafine and itraconazole, and to compare the results with a retrospective study on 35 immunocompetent patients with tinea capitis who were treated with terbinafine (Lamisil^®). Methods: Minimal inhibitory concentrations (MIC) were measured with an agar dilution method. Results: Each tested species of dermatophyte was sensitive to terbinafine and itraconazole at different concentration ranges. The MIC for terbinafine ranged from 0.005 to 0.5 μg/ml and for itraconazole from 40 to 80 μg/ml. Microsporum canis was the dermatophyte least sensitive to terbinafine. Our retrospective study showed that the cure rate was excellent for Trichophyton violaceum and T. soudanense, variable for T. mentagrophytes and poor for M. canis and M. langeronii. Conclusions: (i) Regarding the results of susceptibility tests obtained with species involved in tinea capitis, clinical efficacy is not related to MIC measured in vitro; (ii) identification of the isolated dermatophyte from tinea capitis seems to be important for choosing the appropriate treatment.

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Section: Introductionmentioning

confidence: 92%

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

et al. 1998

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“…[70][71][72] ITR is effective in treating tinea capitis when used as continuous or pulse therapy, which is better tolerated than griseofulvin. [18,31,73] It is necessary to individualize the duration of therapy administered according to the clinical response. The advantages of pulse therapy are better compliance than continuous therapy.…”

Section: Conclusion Superficial Fungal Infectionsmentioning

confidence: 99%

Efficacy and safety of itraconazole use in infants

et al. 2016

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“…However, all 9 non-responders had this dermatophyte, suggesti ng that the durati on of therapy has to be extended beyond 2 weeks in certain cases of T. rubrum infecti on. Although the number of cases resulti ng from other pathogens was small, they do respond to this short-term therapy with drug usually in Tenia capiti s. [6][7][8][9][10][11][12][13] Bothitraconazole and terbinafi ne are highly lipophilic and kerati nophilic. They persist in the stratum corneum and hair in high concentrati ons for 3-4 weeks aft er therapy is disconti nued.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.

Shakya

Jha

Dangol

et al. 2013

Med. J. Shree Birendra Hosp.

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Introducti on: Tenia Cruris is the commonest dermatophyte infecti on which is common in men and aggravated by warm humid conditi on Teniarubrum is the main species for the disease 1,2 . Itraconazole and Terbinafi ne are the bett er newer drugs for the therapeuti c opti on due to their effi cacy, convenient and less side eff ect. Itraconazole is a wider spectrum Thiazole group of fungistati c drugs which inhibit sterol 14 α demethylase impairing biosynthesis of fungal ergosterol. Similarly Terbinafi ne is broad specturmallylamine group of fungicidal acti vity which inhibits squalene 2, 3 epoxidase enzyme thus inhibit fungal biosynsthesis of ergosterol [3][4][5] . These two drugs have been needed conventi onally as a pulse and conti nuous therapy. The main aim of this study is to compare the effi cacy of both drugs and to recommend the eff ecti ve treatment in case of Teniacruris. Methods:In this randomized comparati ve study, the effi cacy and safety of oral itraconazole (n=35) and terbinafi ne (n=35), each given for 2weeks, was compared in pati ents with ti neacruris within the period of 1 year study. Results:The fi nal evaluati on at week 4 showed a cure rate of 91.4% for itraconazole and 82.9% for terbinafi ne. No defi nite adverse eff ect was noted. Conclusions:Itraconazolehas high cure rate and less failure rate without side eff ects in comparision toTerbinafi ne.

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Itraconazole Versus Griseofulvin in the Treatment of Tinea Capitis: A Double‐blind Randomized Study in Children

Abstract: Itraconazole is the first azole derivate that matches griseofulvin for the treatment of tinea capitis in children. The drug also appears to be better tolerated than griseofulvin.

Cited by 112 publications

References 5 publications

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

Efficacy and safety of itraconazole use in infants

Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.

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